PMID- 32732929
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 34
IP  - 1
DP  - 2021 Jan
TI  - A comparative study of RTK gene status between primary tumors, lymph-node 
      metastases, and Krukenberg tumors.
PG  - 42-50
LID - 10.1038/s41379-020-0636-7 [doi]
AB  - Krukenberg tumor (KT) refers to a rare ovarian tumor that has metastasized from a 
      primary site. Patients with KTs have a poorer prognosis and worse survival. Thus 
      far, little is known about the frequency of receptor tyrosine kinase (RTK) gene 
      amplification and the concordance of gene amplification between primary tumors, 
      lymph-node metastases, and KTs. Herein, 50 paired samples, including primary 
      cancers, metastatic lymph nodes, and KTs were collected, and RTK gene 
      amplification was tested by fluorescence in situ hybridization (FISH). There were 
      four cases positive for human epidermal growth factor receptor type 2 (HER2) 
      amplification, all of which showed conversion of HER2 status between different 
      lesions. Of the two cases with c-mesenchymal-epithelial transition (c-MET) 
      amplification, the primary tumors and lymph nodes were negative while the right 
      involved ovaries were positive. Inconsistent fibroblast growth factor receptor 2 
      (FGFR2) status in different lesions was observed in three of the six 
      FGFR2-amplified cases. Co-amplification of RTK genes was identified in only one 
      patient for primary cancer and two for KTs. Collectively, there were 46, 48, 50, 
      and 44 cases negative for HER2, c-MET, EGFR, and FGFR2 amplification in all 
      lesions, respectively. There was no significant difference in overall survival 
      between KTs of gastric origin and colorectal origin. However, of all synchronous 
      cancers, KTs of colorectal origin had a better prognosis than those of gastric 
      origin. In conclusion, the positive rate of RTK gene amplification in KTs was 
      low. Intratumoral heterogeneity was frequent in KTs with RTK gene amplification. 
      A mutually exclusive pattern of RTK gene amplification was dominant in primary 
      cancers, lymph-node metastases, and KTs. There was no survival difference between 
      KTs of gastric origin and colorectal origin. However, of all synchronous cancers, 
      KTs of colorectal origin had a better prognosis than those of gastric origin.
FAU - Wang, Bo
AU  - Wang B
AD  - Department of Pathology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
FAU - Tang, Qiusu
AU  - Tang Q
AD  - Department of Pathology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
AD  - Department of Pathology and Pathophysiology, College of Medicine, Zhejiang 
      University, 310058, Hangzhou, Zhejiang Province, China.
FAU - Xu, Liming
AU  - Xu L
AD  - Department of Pathology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
AD  - Department of Pathology and Pathophysiology, College of Medicine, Zhejiang 
      University, 310058, Hangzhou, Zhejiang Province, China.
FAU - Teng, Xiaodong
AU  - Teng X
AD  - Department of Pathology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
FAU - Ding, Wei
AU  - Ding W
AD  - Department of Pathology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, 310003, Hangzhou, Zhejiang Province, China.
FAU - Ren, Guoping
AU  - Ren G
AD  - Department of Pathology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, 310003, Hangzhou, Zhejiang Province, China. 
      wanglingjane@163.com.
AD  - Department of Pathology and Pathophysiology, College of Medicine, Zhejiang 
      University, 310058, Hangzhou, Zhejiang Province, China. wanglingjane@163.com.
FAU - Wang, Xiaoling
AU  - Wang X
AD  - Department of Pathology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, 310003, Hangzhou, Zhejiang Province, China. 
      1307025@zju.edu.cn.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20200730
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Colorectal Neoplasms/*genetics/secondary
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Krukenberg Tumor/*genetics
MH  - Lymphatic Metastasis/*genetics
MH  - Middle Aged
MH  - Ovarian Neoplasms/*genetics
MH  - Receptor Protein-Tyrosine Kinases/*genetics
MH  - Stomach Neoplasms/*genetics/secondary
EDAT- 2020/08/01 06:00
MHDA- 2021/10/26 06:00
CRDT- 2020/08/01 06:00
PHST- 2020/03/29 00:00 [received]
PHST- 2020/07/16 00:00 [accepted]
PHST- 2020/07/16 00:00 [revised]
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2020/08/01 06:00 [entrez]
AID - S0893-3952(22)00392-1 [pii]
AID - 10.1038/s41379-020-0636-7 [doi]
PST - ppublish
SO  - Mod Pathol. 2021 Jan;34(1):42-50. doi: 10.1038/s41379-020-0636-7. Epub 2020 Jul 
      30.