PMID- 32733266
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 11
DP  - 2020
TI  - The Dark Side of Nrf2 in the Heart.
PG  - 722
LID - 10.3389/fphys.2020.00722 [doi]
LID - 722
AB  - Nuclear factor-erythroid factor 2-related factor 2 (Nrf2) is a critical 
      transcription factor that regulates the expression of over 1000 genes in the cell 
      under normal and stressed conditions. These transcripts can be categorized into 
      different groups with distinct functions, including antioxidative defense, 
      detoxification, inflammatory responses, transcription factors, proteasomal and 
      autophagic degradation, and metabolism. Nevertheless, Nrf2 has been historically 
      considered as a crucial regulator of antioxidant defense to protect against 
      various insult-induced organ damage and has evolved as a promising drug target 
      for the treatment of human diseases, such as heart failure. However, burgeoning 
      evidence has revealed a detrimental role of Nrf2 in cardiac pathological 
      remodeling and dysfunction toward heart failure. In this mini-review, we outline 
      recent advances in structural features of Nrf2 and regulation of Nrf2 activity 
      and discuss the emerging dark side of Nrf2 in the heart as well as the potential 
      mechanisms of Nrf2-mediated myocardial damage and dysfunction.
CI  - Copyright (c) 2020 Zang, Mathew and Cui.
FAU - Zang, Huimei
AU  - Zang H
AD  - Department of Cell Biology and Anatomy, University of South Carolina School of 
      Medicine, Columbia, SC, United States.
FAU - Mathew, Roy Oomen
AU  - Mathew RO
AD  - Division of Nephrology, Department of Medicine, Columbia VA Healthcare System, 
      Columbia, SC, United States.
FAU - Cui, Taixing
AU  - Cui T
AD  - Department of Cell Biology and Anatomy, University of South Carolina School of 
      Medicine, Columbia, SC, United States.
LA  - eng
GR  - R01 HL131667/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20200709
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC7363974
OTO - NOTNLM
OT  - Nrf2
OT  - autophagy
OT  - heart failure
OT  - oxidative stress
OT  - reductive stress
EDAT- 2020/08/01 06:00
MHDA- 2020/08/01 06:01
PMCR- 2020/07/09
CRDT- 2020/08/01 06:00
PHST- 2020/03/29 00:00 [received]
PHST- 2020/06/02 00:00 [accepted]
PHST- 2020/08/01 06:00 [entrez]
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2020/08/01 06:01 [medline]
PHST- 2020/07/09 00:00 [pmc-release]
AID - 10.3389/fphys.2020.00722 [doi]
PST - epublish
SO  - Front Physiol. 2020 Jul 9;11:722. doi: 10.3389/fphys.2020.00722. eCollection 
      2020.