PMID- 32733455 OWN - NLM STAT- MEDLINE DCOM- 20210406 LR - 20210406 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 11 DP - 2020 TI - Preventive Allergen-Specific Vaccination Against Allergy: Mission Possible? PG - 1368 LID - 10.3389/fimmu.2020.01368 [doi] LID - 1368 AB - Vaccines for infectious diseases have improved the life of the human species in a tremendous manner. The principle of vaccination is to establish de novo adaptive immune response consisting of antibody and T cell responses against pathogens which should defend the vaccinated person against future challenge with the culprit pathogen. The situation is completely different for immunoglobulin E (IgE)-associated allergy, an immunologically-mediated hypersensitivity which is already characterized by increased IgE antibody levels and T cell responses against per se innocuous antigens (i.e., allergens). Thus, allergic patients suffer from a deviated hyper-immunity against allergens leading to inflammation upon allergen contact. Paradoxically, vaccination with allergens, termed allergen-specific immunotherapy (AIT), induces a counter immune response based on the production of high levels of allergen-specific IgG antibodies and alterations of the adaptive cellular response, which reduce allergen-induced symptoms of allergic inflammation. AIT was even shown to prevent the progression of mild to severe forms of allergy. Consequently, AIT can be considered as a form of therapeutic vaccination. In this article we describe a strategy and possible road map for the use of an AIT approach for prophylactic vaccination against allergy which is based on new molecular allergy vaccines. This road map includes the use of AIT for secondary preventive vaccination to stop the progression of clinically silent allergic sensitization toward symptomatic allergy and ultimately the prevention of allergic sensitization by maternal vaccination and/or early primary preventive vaccination of children. Prophylactic allergy vaccination with molecular allergy vaccines may allow halting the allergy epidemics affecting almost 30% of the population as it has been achieved for vaccination against infectious diseases. CI - Copyright (c) 2020 Tulaeva, Kratzer, Campana, Curin, van Hage, Karsonova, Riabova, Karaulov, Khaitov, Pickl and Valenta. FAU - Tulaeva, Inna AU - Tulaeva I AD - Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. AD - Laboratory of Immunopathology, Department of Clinical Immunology and Allergology, Sechenov First Moscow State Medical University, Moscow, Russia. FAU - Kratzer, Bernhard AU - Kratzer B AD - Center for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Medical University of Vienna, Vienna, Austria. FAU - Campana, Raffaela AU - Campana R AD - Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. FAU - Curin, Mirela AU - Curin M AD - Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. FAU - van Hage, Marianne AU - van Hage M AD - Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. FAU - Karsonova, Antonina AU - Karsonova A AD - Laboratory of Immunopathology, Department of Clinical Immunology and Allergology, Sechenov First Moscow State Medical University, Moscow, Russia. FAU - Riabova, Ksenja AU - Riabova K AD - Laboratory of Immunopathology, Department of Clinical Immunology and Allergology, Sechenov First Moscow State Medical University, Moscow, Russia. FAU - Karaulov, Alexander AU - Karaulov A AD - Laboratory of Immunopathology, Department of Clinical Immunology and Allergology, Sechenov First Moscow State Medical University, Moscow, Russia. FAU - Khaitov, Musa AU - Khaitov M AD - NRC Institute of Immunology FMBA of Russia, Moscow, Russia. FAU - Pickl, Winfried F AU - Pickl WF AD - Center for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Medical University of Vienna, Vienna, Austria. FAU - Valenta, Rudolf AU - Valenta R AD - Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. AD - Laboratory of Immunopathology, Department of Clinical Immunology and Allergology, Sechenov First Moscow State Medical University, Moscow, Russia. AD - NRC Institute of Immunology FMBA of Russia, Moscow, Russia. AD - Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20200707 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Allergens) RN - 0 (Epitopes, B-Lymphocyte) RN - 0 (Epitopes, T-Lymphocyte) RN - 0 (Peptides) RN - 0 (Vaccines) RN - 0 (Vaccines, Virus-Like Particle) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Allergens/administration & dosage/*immunology MH - Animals MH - Clinical Trials as Topic MH - *Desensitization, Immunologic MH - Epitopes, B-Lymphocyte/immunology MH - Epitopes, T-Lymphocyte/immunology MH - Female MH - Humans MH - Hypersensitivity/*prevention & control/*therapy MH - Immunoglobulin E/immunology MH - Peptides/immunology MH - Pregnancy MH - Primary Prevention MH - Secondary Prevention MH - Treatment Outcome MH - *Vaccination/methods MH - Vaccines/administration & dosage/*immunology MH - Vaccines, Virus-Like Particle/administration & dosage/immunology PMC - PMC7358538 OTO - NOTNLM OT - IgE OT - allergen OT - allergen-specific immunotherapy OT - allergy OT - molecular allergy vaccine OT - therapeutic vaccine OT - vaccination OT - vaccine EDAT- 2020/08/01 06:00 MHDA- 2021/04/07 06:00 PMCR- 2020/01/01 CRDT- 2020/08/01 06:00 PHST- 2020/02/14 00:00 [received] PHST- 2020/05/28 00:00 [accepted] PHST- 2020/08/01 06:00 [entrez] PHST- 2020/08/01 06:00 [pubmed] PHST- 2021/04/07 06:00 [medline] PHST- 2020/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2020.01368 [doi] PST - epublish SO - Front Immunol. 2020 Jul 7;11:1368. doi: 10.3389/fimmu.2020.01368. eCollection 2020.