PMID- 32733567
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1687-8760 (Print)
IS  - 1687-8779 (Electronic)
IS  - 1687-8760 (Linking)
VI  - 2020
DP  - 2020
TI  - Simultaneous Quantification of gamma-Hydroxybutyrate, gamma-Butyrolactone, and 
      1,4-Butanediol in Four Kinds of Beverages.
PG  - 8837743
LID - 10.1155/2020/8837743 [doi]
LID - 8837743
AB  - gamma-Hydroxybutyrate (GHB) is a neurotransmitter, which exhibits a strong central 
      nervous system depressant effect. The abuse of GHB or its precursor substances 
      (gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD)) may cause serious problems. 
      This study developed a fast and effective UHPLC-MS/MS method for the simultaneous 
      quantification of GHB, GBL, and 1,4-BD in four popular beverages, including 
      carbonated drinks, tea, apple cider vinegar, and coffee. The established method 
      overcomes the influence of the in-source collision-induced dissociation of 
      unstable compounds during quantification. The limits of detection were 0.2 mug/mL 
      for GBL and 0.5 mug/mL for GHB and 1,4-BD with excellent linearity in the range of 
      0.2-50 mug/mL. The recoveries of the three compounds at three spiked levels (2.5, 
      5.0, and 10.0 mug/mL) in the four kinds of beverages studied were between 90 and 
      110%, while the relative standard deviations (RSDs) were all <10%. The matrix 
      effect was negligible using this simple and appropriate preprocessed procedure. 
      The method established in this study can quickly and reliably detect the GHB 
      content and its analogues in beverages.
CI  - Copyright (c) 2020 Shaoming Jin et al.
FAU - Jin, Shaoming
AU  - Jin S
AD  - National Institutes for Food and Drug Control, 100050 Beijing, China.
FAU - Ning, Xiao
AU  - Ning X
AD  - National Institutes for Food and Drug Control, 100050 Beijing, China.
FAU - Cao, Jin
AU  - Cao J
AD  - National Institutes for Food and Drug Control, 100050 Beijing, China.
FAU - Wang, Yaonan
AU  - Wang Y
AUID- ORCID: 0000-0003-2159-2730
AD  - Core Facilities Centre, Capital Medical University, 100069 Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20200715
PL  - Egypt
TA  - Int J Anal Chem
JT  - International journal of analytical chemistry
JID - 101519424
PMC - PMC7378593
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/08/01 06:00
MHDA- 2020/08/01 06:01
PMCR- 2020/07/15
CRDT- 2020/08/01 06:00
PHST- 2020/05/21 00:00 [received]
PHST- 2020/06/24 00:00 [revised]
PHST- 2020/07/01 00:00 [accepted]
PHST- 2020/08/01 06:00 [entrez]
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2020/08/01 06:01 [medline]
PHST- 2020/07/15 00:00 [pmc-release]
AID - 10.1155/2020/8837743 [doi]
PST - epublish
SO  - Int J Anal Chem. 2020 Jul 15;2020:8837743. doi: 10.1155/2020/8837743. eCollection 
      2020.