PMID- 32735129
OWN - NLM
STAT- MEDLINE
DCOM- 20210902
LR  - 20220729
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 40
IP  - 1
DP  - 2021 Jan
TI  - Arsenite induces dysfunction of regulatory T cells through acetylation control of 
      the Foxp3 promoter.
PG  - 35-46
LID - 10.1177/0960327120934533 [doi]
AB  - Arsenic is known to cause damage to the body's immune system by inducing 
      epigenetic changes. However, the molecular mechanism of this damage remains 
      elusive. Here, we report that arsenic disrupts the morphology of lymphocytes, 
      decreases cell viability, and results in abnormal proportions of T lymphocyte 
      subsets. Moreover, our results revealed that arsenic can reduce global 
      acetylation of histone H4 at K16 (H4K16 ac) in lymphocytes via decreasing the 
      level of males absent on the first but upregulates mRNA and protein levels of the 
      forkhead/winged-helix box P3 (Foxp3) gene by increasing the acetylation of 
      histone H4 at K16 (H4K16) at the promoter of Foxp3. Finally, arsenic-induced 
      dysfunction of regulatory T cells (Tregs) could be ameliorated by trichostatin A. 
      Our research indicates that arsenic-induced immunosuppressive effect in human 
      lymphocytes may be related to the acetylation of H4K16 at the promoter of Foxp3 
      and that histone deacetylase inhibitors may play a role in the prevention and 
      treatment of immune injury caused by arsenic.
FAU - Chen, J
AU  - Chen J
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
FAU - Jiang, J
AU  - Jiang J
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
FAU - Liu, Y
AU  - Liu Y
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
FAU - Ye, Y
AU  - Ye Y
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
FAU - Ma, Y
AU  - Ma Y
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
FAU - Cen, Y
AU  - Cen Y
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
FAU - Chen, W
AU  - Chen W
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
FAU - Wang, S
AU  - Wang S
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
FAU - Yang, G
AU  - Yang G
AUID- ORCID: 0000-0002-6430-1852
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
FAU - Zhang, A
AU  - Zhang A
AD  - Key Laboratory of Environmental Pollution Monitoring and Disease Control, School 
      of Public Health, 74628Guizhou Medical University, Guiyang, China.
LA  - eng
PT  - Journal Article
DEP - 20200731
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Arsenites)
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (Histones)
RN  - 0 (Hydroxamic Acids)
RN  - 3X2S926L3Z (trichostatin A)
SB  - IM
MH  - Acetylation
MH  - Arsenites/*toxicity
MH  - *Forkhead Transcription Factors/metabolism
MH  - Histone Deacetylase Inhibitors
MH  - Histones
MH  - Humans
MH  - Hydroxamic Acids
MH  - Promoter Regions, Genetic
MH  - Protein Processing, Post-Translational
MH  - T-Lymphocytes, Regulatory/*drug effects
OTO - NOTNLM
OT  - Arsenic
OT  - Foxp3
OT  - H4K16 ac
OT  - TSA
OT  - lymphocyte
EDAT- 2020/08/01 06:00
MHDA- 2021/09/03 06:00
CRDT- 2020/08/01 06:00
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2021/09/03 06:00 [medline]
PHST- 2020/08/01 06:00 [entrez]
AID - 10.1177/0960327120934533 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2021 Jan;40(1):35-46. doi: 10.1177/0960327120934533. Epub 2020 
      Jul 31.