PMID- 32735319
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20230517
IS  - 1367-4811 (Electronic)
IS  - 1367-4803 (Print)
IS  - 1367-4803 (Linking)
VI  - 37
IP  - 3
DP  - 2021 Apr 20
TI  - HATK: HLA analysis toolkit.
PG  - 416-418
LID - 10.1093/bioinformatics/btaa684 [doi]
AB  - SUMMARY: Fine-mapping human leukocyte antigen (HLA) genes involved in disease 
      susceptibility to individual alleles or amino acid residues has been challenging. 
      Using information regarding HLA alleles obtained from HLA typing, HLA imputation 
      or HLA inference, our software expands the alleles to amino acid sequences using 
      the most recent IMGT/HLA database and prepares a dataset suitable for 
      fine-mapping analysis. Our software also provides useful functionalities, such as 
      various association tests, visualization tools and nomenclature conversion. 
      AVAILABILITY AND IMPLEMENTATION: https://github.com/WansonChoi/HATK.
CI  - (c) The Author(s) 2020. Published by Oxford University Press.
FAU - Choi, Wanson
AU  - Choi W
AD  - Department of Biomedical Sciences, BK21 Plus Biomedical Science Project, Seoul 
      National University College of Medicine, Seoul 03080, Republic of Korea.
FAU - Luo, Yang
AU  - Luo Y
AD  - Division of Genetics, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, MA 02115, USA.
AD  - Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, 
      Cambridge, MA 02142, USA.
AD  - Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, MA 02115, USA.
AD  - Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, 
      Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
AD  - Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, 
      USA.
FAU - Raychaudhuri, Soumya
AU  - Raychaudhuri S
AD  - Division of Genetics, Department of Medicine, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, MA 02115, USA.
AD  - Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, 
      Cambridge, MA 02142, USA.
AD  - Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, 
      Boston, MA 02115, USA.
AD  - Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, 
      Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
AD  - Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, 
      USA.
AD  - Centre for Genetics and Genomics Versus Arthritis, Manchester Academic Health 
      Science Centre, University of Manchester, Manchester M13 9PL, UK.
FAU - Han, Buhm
AU  - Han B
AD  - Department of Biomedical Sciences, BK21 Plus Biomedical Science Project, Seoul 
      National University College of Medicine, Seoul 03080, Republic of Korea.
LA  - eng
GR  - U19 AI111224/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioinformatics
JT  - Bioinformatics (Oxford, England)
JID - 9808944
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Chromosome Mapping
MH  - Genetic Predisposition to Disease
MH  - *HLA Antigens/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Software
PMC - PMC8058762
EDAT- 2020/08/01 06:00
MHDA- 2021/04/29 06:00
PMCR- 2020/07/31
CRDT- 2020/08/01 06:00
PHST- 2020/01/03 00:00 [received]
PHST- 2020/07/01 00:00 [revised]
PHST- 2020/07/24 00:00 [accepted]
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2020/08/01 06:00 [entrez]
PHST- 2020/07/31 00:00 [pmc-release]
AID - 5879278 [pii]
AID - btaa684 [pii]
AID - 10.1093/bioinformatics/btaa684 [doi]
PST - ppublish
SO  - Bioinformatics. 2021 Apr 20;37(3):416-418. doi: 10.1093/bioinformatics/btaa684.