PMID- 32735895
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 190
DP  - 2020 Sep
TI  - Effects of ten-week 30% caloric restriction on metabolic health and skeletal 
      muscles of adult and old C57BL/6J mice.
PG  - 111320
LID - S0047-6374(20)30116-0 [pii]
LID - 10.1016/j.mad.2020.111320 [doi]
AB  - Caloric restriction (CR) can improve health, but the benefits are age-dependant. 
      We studied effects of ten-week 30 % CR on skeletal muscles of adult (7-month old) 
      and old (24-month old) C57BL/6 J mice. Old mice were heavier than adult mice 
      (36.1 +/- 4.0 g versus 32.9 +/- 2.3 g, p < 0.05, respectively), but lost more weight 
      (34.7 +/- 6.0 % versus 23.9 +/- 3.3 %, p < 0.001, respectively) during CR. Old mice 
      did not differ from adult mice in extent of hind-limb muscle wasting or 
      improvement in glucose tolerance after CR. Ageing and CR had an additive effect 
      on increase in percentage of type 1 fibres in the soleus (SOL) muscle. CR was 
      associated with greater atrophy of fast-twitch extensor digitorum longus (EDL) 
      compared to slow-twitch SOL muscle. Old mice showed reduced gene expression of 
      lysosomal markers, p62 and LC3B, while CR tended to upregulate the proteolysis 
      genes. CR was also associated with increase in specific force of EDL muscle, but 
      did not affect it in SOL muscle. In summary, ten-week CR induces only limited 
      improvements in skeletal muscle function, but leads to significant muscle wasting 
      and weakness in both adult and old mice.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Kvedaras, Mindaugas
AU  - Kvedaras M
AD  - Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, 
      Lithuania.
FAU - Minderis, Petras
AU  - Minderis P
AD  - Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, 
      Lithuania.
FAU - Krusnauskas, Raulas
AU  - Krusnauskas R
AD  - Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, 
      Lithuania.
FAU - Ratkevicius, Aivaras
AU  - Ratkevicius A
AD  - Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, 
      Lithuania; Department of Health Promotion and Rehabilitation, Lithuanian Sports 
      University, Kaunas, Lithuania. Electronic address: Aivaras.Ratkevicius@lsu.lt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200728
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
SB  - IM
MH  - Age Factors
MH  - *Aging/pathology/physiology
MH  - Animals
MH  - *Caloric Restriction/adverse effects/methods
MH  - Glucose Tolerance Test
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Muscle, Skeletal/metabolism/pathology/physiopathology
MH  - Muscular Atrophy/etiology/pathology
MH  - Sarcopenia/etiology/physiopathology
MH  - Weight Loss
OTO - NOTNLM
OT  - Caloric restriction
OT  - Glucose tolerance
OT  - Muscle fibre composition
OT  - Sarcopenia
OT  - Skeletal muscle
EDAT- 2020/08/01 06:00
MHDA- 2021/09/14 06:00
CRDT- 2020/08/01 06:00
PHST- 2020/05/03 00:00 [received]
PHST- 2020/07/20 00:00 [revised]
PHST- 2020/07/24 00:00 [accepted]
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2020/08/01 06:00 [entrez]
AID - S0047-6374(20)30116-0 [pii]
AID - 10.1016/j.mad.2020.111320 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2020 Sep;190:111320. doi: 10.1016/j.mad.2020.111320. Epub 2020 
      Jul 28.