PMID- 32736011
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20211230
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 26
IP  - 12
DP  - 2020 Dec
TI  - Guidelines for Cord Blood Unit Selection.
PG  - 2190-2196
LID - S1083-8791(20)30456-0 [pii]
LID - 10.1016/j.bbmt.2020.07.030 [doi]
AB  - Optimal cord blood (CB) unit selection is critical to maximize the likelihood of 
      successful engraftment and survival after CB transplantation (CBT). However, unit 
      selection can be complex because multiple characteristics must be considered 
      including unit cell dose, donor-recipient human leukocyte antigen (HLA) match, 
      and unit quality. This review provides evidence-based and experience-based 
      comprehensive guidelines for CB unit selection. Topics addressed include the use 
      of both the TNC and the CD34(+) cell dose, as well as the CD34(+) cell to TNC 
      content ratio to evaluate unit progenitor cell content and engraftment potential, 
      the acceptable TNC and CD34(+) cell dose criteria that define an adequate 
      single-unit graft, and the indication and acceptable cell dose criteria for 
      double-unit grafts. The acceptable criteria for 6-loci (HLA-A, -B antigen, -DRB1 
      allele) and 8-allele (HLA-A, -B, -C, -DRB1) donor-recipient HLA match, the 
      evaluation of patients with donor-specific HLA antibodies, and the multiple 
      determinants of unit quality are also reviewed in detail. Finally, a practical 
      step-by-step guide to CB searches and the principles that guide ultimate graft 
      selection are outlined.
CI  - Copyright (c) 2020 American Society for Transplantation and Cellular Therapy. 
      Published by Elsevier Inc. All rights reserved.
FAU - Politikos, Ioannis
AU  - Politikos I
AD  - Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, New York. Electronic address: 
      politiki@mskcc.org.
FAU - Davis, Eric
AU  - Davis E
AD  - Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, New York.
FAU - Nhaissi, Melissa
AU  - Nhaissi M
AD  - Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, New York.
FAU - Wagner, John E
AU  - Wagner JE
AD  - Blood and Marrow Transplant Program, Department of Pediatrics, University of 
      Minnesota, Minneapolis, Minnesota.
FAU - Brunstein, Claudio G
AU  - Brunstein CG
AD  - Division of Hematology, Oncology and Transplantation, University of Minnesota, 
      Minneapolis, Minnesota.
FAU - Cohen, Sandra
AU  - Cohen S
AD  - Division of Hematology, Department of Medicine, Maisonneuve-Rosemont Hospital, 
      Montreal, Quebec, Canada.
FAU - Shpall, Elizabeth J
AU  - Shpall EJ
AD  - Department of Stem Cell Transplant and Cellular Therapy, University of Texas MD 
      Anderson Cancer Center, Houston, Texas.
FAU - Milano, Filippo
AU  - Milano F
AD  - Clinical Research Division, Fred Hutchinson Cancer Research Center & Department 
      of Medicine, University of Washington, Seattle, Washington.
FAU - Scaradavou, Andromachi
AU  - Scaradavou A
AD  - Stem Cell Transplantation and Cellular Therapies, MSK Kids, New York, New York.
FAU - Barker, Juliet N
AU  - Barker JN
AD  - Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan 
      Kettering Cancer Center, New York, New York.
CN  - American Society for Transplantation and Cellular Therapy Cord Blood Special 
      Interest Group
LA  - eng
GR  - P01 CA065493/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Practice Guideline
PT  - Review
DEP - 20200728
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for 
      Blood and Marrow Transplantation
JID - 9600628
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Cord Blood Stem Cell Transplantation
MH  - Fetal Blood
MH  - HLA Antigens
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Tissue Donors
OTO - NOTNLM
OT  - CB unit selection
OT  - CD34+ cell dose
OT  - HLA match
OT  - TNC dose
EDAT- 2020/08/01 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/08/01 06:00
PHST- 2020/07/21 00:00 [received]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/08/01 06:00 [entrez]
AID - S1083-8791(20)30456-0 [pii]
AID - 10.1016/j.bbmt.2020.07.030 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2020 Dec;26(12):2190-2196. doi: 
      10.1016/j.bbmt.2020.07.030. Epub 2020 Jul 28.