PMID- 32736014
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1096-1208 (Electronic)
IS  - 0882-4010 (Linking)
VI  - 147
DP  - 2020 Oct
TI  - Differential role of lipoteichoic acids isolated from Staphylococcus aureus and 
      Lactobacillus plantarum on the aggravation and alleviation of atopic dermatitis.
PG  - 104360
LID - S0882-4010(20)30726-9 [pii]
LID - 10.1016/j.micpath.2020.104360 [doi]
AB  - Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, 
      up-regulates inflammatory cytokine production through the toll-like receptor 2 
      (TLR2) signaling pathway, and also contributes to anti-inflammatory responses 
      against immune cells stimulated by lipopolysaccharides. In the current study, we 
      examined the effects of LTAs isolated from Staphylococcus aureus (aLTA) and 
      Lactobacillus plantarum (pLTA) on the aggravation and alleviation of atopic 
      dermatitis (AD). aLTA strongly induced CCL2 production in THP-1 cells. CCL2 was 
      regulated by the TLR2 pathway including the activation of IRAK2, NF-kappaB and JNK. 
      CCL2 induced Th2 polarization of CD4+T cells through induction of interleukin 
      (IL)-2, -4, and -5 and inhibition of interferon-gamma (IFN-gamma). CCL2 levels and 
      immunoglobulin E (IgE) production were increased in aLTA-injected mice. On the 
      other hand, pLTA moderately affected CCL2 production and it inhibited 
      aLTA-mediated CCL2 production. The serum levels of CCL2 and IgE were inhibited by 
      pLTA pre-injection followed by aLTA reinjection, which resulted in the 
      alleviation of irritant contact dermatitis (ICD) symptoms. Our results suggest 
      that S. aureus infection causes an increase in CCL2 production, and may 
      exacerbate atopic dermatitis (AD)-like symptoms through the excessive IgE 
      production. Alternatively, pLTA alleviated AD-like symptoms by inhibiting 
      aLTA-induced CCL2 and IgE production.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Kim, Yenny
AU  - Kim Y
AD  - Graduate School of Biotechnology, Kyung Hee University, Yongin, 17104, Republic 
      of Korea.
FAU - Park, Jae Yeon
AU  - Park JY
AD  - Graduate School of Biotechnology, Kyung Hee University, Yongin, 17104, Republic 
      of Korea.
FAU - Kim, Hangeun
AU  - Kim H
AD  - Research & Development Center, Skin Biotechnology Center Inc., Yongin, 17104, 
      Republic of Korea. Electronic address: hkim93@khu.ac.kr.
FAU - Chung, Dae Kyun
AU  - Chung DK
AD  - Graduate School of Biotechnology, Kyung Hee University, Yongin, 17104, Republic 
      of Korea; Research & Development Center, Skin Biotechnology Center Inc., Yongin, 
      17104, Republic of Korea. Electronic address: dkchung@khu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20200729
PL  - England
TA  - Microb Pathog
JT  - Microbial pathogenesis
JID - 8606191
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Teichoic Acids)
RN  - 56411-57-5 (lipoteichoic acid)
SB  - IM
MH  - Animals
MH  - *Dermatitis, Atopic
MH  - *Lactobacillus plantarum
MH  - Lipopolysaccharides
MH  - Mice
MH  - Staphylococcus aureus
MH  - Teichoic Acids
OTO - NOTNLM
OT  - Chemokine (C-C motif) ligand 2 (CCL2)
OT  - Lactobacillus plantarum
OT  - Lipoteichoic acid
OT  - Staphylococcus aureus
OT  - Th1/Th2 response
OT  - Toll-like receptor 2
EDAT- 2020/08/01 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/08/01 06:00
PHST- 2020/01/02 00:00 [received]
PHST- 2020/05/14 00:00 [revised]
PHST- 2020/06/22 00:00 [accepted]
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/08/01 06:00 [entrez]
AID - S0882-4010(20)30726-9 [pii]
AID - 10.1016/j.micpath.2020.104360 [doi]
PST - ppublish
SO  - Microb Pathog. 2020 Oct;147:104360. doi: 10.1016/j.micpath.2020.104360. Epub 2020 
      Jul 29.