PMID- 32736206
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20221207
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 81
DP  - 2020 Oct
TI  - The Association Between HLA-A*03:01 and HLA-B*07:02 Alleles and 
      Oxcarbazepine-induced Maculopapular Eruption in the Uighur Chinese Population.
PG  - 43-46
LID - S1059-1311(20)30135-7 [pii]
LID - 10.1016/j.seizure.2020.05.006 [doi]
AB  - PURPOSE: To determine genetic associations between oxcarbazepine (OXC)-induced 
      maculopapular eruption (MPE) and human leukocyte antigen (HLA) variants in the 
      Uighur Chinese population. METHODS: A total of 208 patients were enrolled in this 
      study, including 20 subjects with OXC-induced MPE (case group) and 188 
      OXC-tolerant patients (control group). We detected the whole sequence of the HLA 
      alleles in the 208 Uighur patients using next-generation sequencing (NGS). 
      RESULTS: The carried rate of HLA-A*03:01 was significantly different between the 
      OXC-induced MPE group and the tolerant group (7/20, 35% versus 4/188, 2.13%; P = 
      0.000, odds ratio [OR] = 24.77, 95% confidence interval [CI] = 6.41-95.65). 
      Additionally, the carried rate of HLA-B*07:02 was significantly different between 
      the OXC-induced MPE group and the tolerant group (3/20, 15% versus 2/188, 0.011%; 
      P = 0.000, odds ratio [OR] = 16.41, 95% confidence interval (CI) = 2.56-105.09). 
      CONCLUSIONS: HLA-A*03:01 and HLA-B*07:02 may be the risk alleles for MPE in the 
      Uighur Chinese population.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Zhao, Ting
AU  - Zhao T
AD  - Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province, 830001, China; Institute of Clinical Pharmacy, 
      People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Province 
      830001, China. Electronic address: 445839342@qq.com.
FAU - Wang, Ting-Ting
AU  - Wang TT
AD  - Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province, 830001, China; Institute of Clinical Pharmacy, 
      People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Province 
      830001, China.
FAU - Jia, Li
AU  - Jia L
AD  - Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang Province 830001, China.
FAU - Wang, Feng
AU  - Wang F
AD  - Department of Neurology, Children's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province 830001, China.
FAU - Bahatibieke, Maerjiang
AU  - Bahatibieke M
AD  - Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang Province 830001, China.
FAU - Liu, Wen-Li
AU  - Liu WL
AD  - Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang Province 830001, China.
FAU - Ji, Yong
AU  - Ji Y
AD  - Xinjiang Dingju Biotechnology Co., Ltd., Urumqi, Xinjiang Province, 830001, 
      China.
FAU - Sun, Li
AU  - Sun L
AD  - Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang Province 830001, China.
FAU - Sun, Yan
AU  - Sun Y
AD  - Department of Neurology, Children's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province 830001, China.
FAU - Li, Hong-Jian
AU  - Li HJ
AD  - Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province, 830001, China; Institute of Clinical Pharmacy, 
      People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Province 
      830001, China. Electronic address: leehongjian@sina.com.
FAU - Yu, Lu-Hai
AU  - Yu LH
AD  - Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province, 830001, China; Institute of Clinical Pharmacy, 
      People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Province 
      830001, China. Electronic address: 1523264450@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20200523
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*07 antigen)
RN  - 0 (HLA-B7 Antigen)
RN  - 33CM23913M (Carbamazepine)
RN  - VZI5B1W380 (Oxcarbazepine)
SB  - IM
MH  - Alleles
MH  - *Anticonvulsants/adverse effects
MH  - Asian People/genetics
MH  - *Carbamazepine/adverse effects
MH  - China
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-B7 Antigen
MH  - Humans
MH  - Oxcarbazepine
OTO - NOTNLM
OT  - HLA-A*03:01
OT  - HLA-B*07:02
OT  - Maculopapule
OT  - Oxcarbazepine
EDAT- 2020/08/01 06:00
MHDA- 2021/07/29 06:00
CRDT- 2020/08/01 06:00
PHST- 2019/12/23 00:00 [received]
PHST- 2020/05/04 00:00 [revised]
PHST- 2020/05/06 00:00 [accepted]
PHST- 2020/08/01 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2020/08/01 06:00 [entrez]
AID - S1059-1311(20)30135-7 [pii]
AID - 10.1016/j.seizure.2020.05.006 [doi]
PST - ppublish
SO  - Seizure. 2020 Oct;81:43-46. doi: 10.1016/j.seizure.2020.05.006. Epub 2020 May 23.