PMID- 32738345
OWN - NLM
STAT- MEDLINE
DCOM- 20210303
LR  - 20210303
IS  - 1090-2422 (Electronic)
IS  - 0014-4827 (Linking)
VI  - 395
IP  - 2
DP  - 2020 Oct 15
TI  - Tumorigenesis and Progression As A Consequence of Hypoxic TME：A Prospective View 
      upon Breast Cancer Therapeutic Targets.
PG  - 112192
LID - S0014-4827(20)30441-9 [pii]
LID - 10.1016/j.yexcr.2020.112192 [doi]
AB  - Intratumoral hypoxia has a significant impact on the development and progression 
      of breast cancer (BC). Rather than exerting limited regional impact, hypoxia 
      create an aggressive macroenvironment for BC. Hypoxia-inducible factors-1(HIF-1) 
      is extensively induced under hypoxia condition of BC, activating the 
      transcription of multiple oncogenes. Thereinto, CD73 is the one which could be 
      secreted into the microenvironment and is in favor of the growth, metastasis, 
      resistance to therapies, as well as the stemness maintenance of BC. In this 
      review, we address the significance of hypoxia/HIF-1/CD73 axis for BC, and 
      provide a novel perspective into BC therapeutic strategies.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Chen, Xiguang
AU  - Chen X
AD  - Department of Medical Oncology, The First Affiliated Hospital of University of 
      South China, Hengyang, Hunan, 421001, PR China.
FAU - Wu, Chen
AU  - Wu C
AD  - Department of Medical Oncology, The First Affiliated Hospital of University of 
      South China, Hengyang, Hunan, 421001, PR China.
FAU - Zhong, Jing
AU  - Zhong J
AD  - Institute of Clinical Medicine, The First Affiliated Hospital of University of 
      South China, Hengyang, Hunan, 421001, PR China.
FAU - Shen, Yingying
AU  - Shen Y
AD  - Institute of Clinical Medicine, The First Affiliated Hospital of University of 
      South China, Hengyang, Hunan, 421001, PR China. Electronic address: 
      shenyingying1113@126.com.
FAU - Zu, Xuyu
AU  - Zu X
AD  - Institute of Clinical Medicine, The First Affiliated Hospital of University of 
      South China, Hengyang, Hunan, 421001, PR China. Electronic address: 
      zuxuyu0108@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200730
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
SB  - IM
MH  - Breast Neoplasms/*metabolism/pathology
MH  - Carcinogenesis/metabolism
MH  - Cell Transformation, Neoplastic/*metabolism
MH  - Epithelial-Mesenchymal Transition/*physiology
MH  - Gene Expression Regulation, Neoplastic/*physiology
MH  - Tumor Microenvironment/physiology
OTO - NOTNLM
OT  - Breast cancer
OT  - CD73
OT  - HIF-1
OT  - Hypoxia
OT  - Therapeutic targets
EDAT- 2020/08/02 06:00
MHDA- 2021/03/04 06:00
CRDT- 2020/08/02 06:00
PHST- 2019/10/22 00:00 [received]
PHST- 2020/06/28 00:00 [revised]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/08/02 06:00 [pubmed]
PHST- 2021/03/04 06:00 [medline]
PHST- 2020/08/02 06:00 [entrez]
AID - S0014-4827(20)30441-9 [pii]
AID - 10.1016/j.yexcr.2020.112192 [doi]
PST - ppublish
SO  - Exp Cell Res. 2020 Oct 15;395(2):112192. doi: 10.1016/j.yexcr.2020.112192. Epub 
      2020 Jul 30.