PMID- 32738367
OWN - NLM
STAT- MEDLINE
DCOM- 20210521
LR  - 20210521
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 144
DP  - 2020 Oct
TI  - Curcumin-loaded poly(ϵ-caprolactone) lipid-core nanocapsules: Evaluation of fetal 
      and maternal toxicity.
PG  - 111625
LID - S0278-6915(20)30515-9 [pii]
LID - 10.1016/j.fct.2020.111625 [doi]
AB  - This study was designed to examine fetal and maternal toxicity of curcumin (CURC) 
      loaded lipid-core nanocapsules (LNC) prepared with poly(ϵ-caprolactone) as a 
      polymer, administered during the organogenesis period. Free CURC and CURC 
      loaded-LNC (C-LNC) (2 mg/kg), blank LNC (B-LNC) and saline (CONTROL) were 
      administered per oral route from the 7 degrees  to 13 degrees  gestational day (GD). Dams were 
      evaluated daily for body weight gain, clinical signs, water and food intake. On 
      20 degrees  GD, dams were euthanized, organs were weighed and blood was collected for 
      biochemical determinations. Fetal biometrics and external morphological anomalies 
      were assessed. Also, were performed histopathological analysis of placenta and 
      measurement of cytokines levels in placental and fetal liver tissues. All groups 
      did not cause changes in dams during the pregnancy. Furthermore, treatments did 
      not cause external morphological changes and delayed fetal development. Still, 
      for histopathological analysis of placental tissue, treatments did not cause 
      alterations in evaluated parameters. For cytokines levels, CURC and C-LNC caused 
      a decrease in placental levels of TNF-alpha. Therefore, we have demonstrated that 
      C-LNC did not cause toxicological effects (mother and fetus), in the same manner 
      as pattern bioactive compound, proving to be a promising nutraceutical delivery 
      system for maternal supplementation with CURC.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Giacomeli, Renata
AU  - Giacomeli R
AD  - Programa de Pos-Graduacao em Bioquimica, Universidade Federal do Pampa, UNIPAMPA, 
      Uruguaiana, RS, 97500-970, Brazil.
FAU - Guerra Teixeira, Flavia Elizabete
AU  - Guerra Teixeira FE
AD  - Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do 
      Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
FAU - Carvalho, Felipe Barbosa
AU  - Carvalho FB
AD  - Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do 
      Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
FAU - Pacheco, Camila Oliveira
AU  - Pacheco CO
AD  - Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do 
      Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
FAU - Martins Parisotto, Alcides Jose
AU  - Martins Parisotto AJ
AD  - Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do 
      Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
FAU - Funguetto Ribeiro, Ana Claudia
AU  - Funguetto Ribeiro AC
AD  - Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do 
      Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
FAU - Gomes de Gomes, Marcelo
AU  - Gomes de Gomes M
AD  - Programa de Pos-Graduacao em Ciencias Farmaceuticas, Universidade Federal do 
      Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
FAU - Haas, Sandra Elisa
AU  - Haas SE
AD  - Programa de Pos-Graduacao em Bioquimica, Universidade Federal do Pampa, UNIPAMPA, 
      Uruguaiana, RS, 97500-970, Brazil; Programa de Pos-Graduacao em Ciencias 
      Farmaceuticas, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 
      97500-970, Brazil. Electronic address: sandrahaas@unipampa.edu.br.
LA  - eng
PT  - Journal Article
DEP - 20200729
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Cytokines)
RN  - 0 (Lipids)
RN  - 0 (Nanocapsules)
RN  - 0 (Polyesters)
RN  - 24980-41-4 (polycaprolactone)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Curcumin/*administration & dosage
MH  - Cytokines/metabolism
MH  - Drinking Behavior/drug effects
MH  - Feeding Behavior/drug effects
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Lipids/*chemistry
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - *Nanocapsules
MH  - Placenta/*drug effects/metabolism
MH  - Polyesters/*administration & dosage
MH  - Pregnancy
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Curcumin
OT  - Nanoparticles
OT  - Nutraceutical delivery system
OT  - Pregnancy
EDAT- 2020/08/02 06:00
MHDA- 2021/05/22 06:00
CRDT- 2020/08/02 06:00
PHST- 2020/05/31 00:00 [received]
PHST- 2020/07/06 00:00 [revised]
PHST- 2020/07/15 00:00 [accepted]
PHST- 2020/08/02 06:00 [pubmed]
PHST- 2021/05/22 06:00 [medline]
PHST- 2020/08/02 06:00 [entrez]
AID - S0278-6915(20)30515-9 [pii]
AID - 10.1016/j.fct.2020.111625 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2020 Oct;144:111625. doi: 10.1016/j.fct.2020.111625. Epub 2020 
      Jul 29.