PMID- 32738526
OWN - NLM
STAT- MEDLINE
DCOM- 20210322
LR  - 20210322
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1153
DP  - 2020 Sep 15
TI  - Determination of ketamine, methamphetamine and 3,4-methylenedioxymethamphetamine 
      in human hair by flash evaporation-gas chromatography/mass spectrometry.
PG  - 122275
LID - S1570-0232(19)31800-8 [pii]
LID - 10.1016/j.jchromb.2020.122275 [doi]
AB  - A rapid and sensitive method utilizing flash evaporation-gas chromatography/mass 
      spectrometry (FE-GC/MS) has been developed. The method is applicable to determine 
      ketamine (KET), methamphetamine (MAMP) and 3,4-methylenedioxymethamphetamine 
      (MDMA) in human hair. Cut and weighted hair (0.30 mg) was heated at the flash 
      evaporation temperature of 350  degrees C. KET, MAMP and MDMA were released into a 
      capillary column for GC/MS analysis and produced fragment ions in SIM mode. 
      Validation of the method included evaluation of linearity, sensitivity, accuracy, 
      precision and repeatability. Linearity ranged from 2 to 300 ng/mg for KET in hair 
      and 2 to 200 ng/mg for MAMP and MDMA in hair with the correlation coefficients 
      all greater than 0.998. Limits of detection were 0.7 ng/mg and limits of 
      quantification were 2.0 ng/mg of hair for KET, MAMP and MDMA. The precision 
      ranged from 1.57% to 7.75% for KET, 1.49% to 7.10% for MAMP and 1.84% to 8.31% 
      for MDMA. The recovery ranged from 102.1% to 110.9% for KET, 99.3% to 108.0% for 
      MAMP and 89.5% to 112.6% for MDMA. Six authentic hair samples from known drug 
      abusers and three drug-free hair samples from volunteers who had never used drugs 
      were successfully analyzed. Compared with traditional time-consuming and 
      hair-comsuming pretreatment method, FE-GC/MS was a faster, simpler and low sample 
      consumption method for the determination of KET, MAMP and MDMA in human hair.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Liu, Yanshuxian
AU  - Liu Y
AD  - College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 
      310014, China.
FAU - Fan, Yilei
AU  - Fan Y
AD  - Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, 
      Zhejiang Police College, Hangzhou, PR China.
FAU - Huang, Zhongping
AU  - Huang Z
AD  - College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 
      310014, China. Electronic address: zhongpingh@126.com.
FAU - Liu, Huijun
AU  - Liu H
AD  - College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 
      310014, China.
FAU - Wang, Lili
AU  - Wang L
AD  - College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 
      310014, China.
FAU - Shen, Zhenlu
AU  - Shen Z
AD  - College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 
      310014, China.
FAU - Watanabe, Ichi
AU  - Watanabe I
AD  - Frontier Laboratories Ltd., Fukushima 9638862, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200716
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 44RAL3456C (Methamphetamine)
RN  - 690G0D6V8H (Ketamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hair/*chemistry
MH  - Humans
MH  - Ketamine/*analysis
MH  - Limit of Detection
MH  - Linear Models
MH  - Methamphetamine/*analysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis
MH  - Reproducibility of Results
MH  - Substance Abuse Detection
OTO - NOTNLM
OT  - 3,4-Methylenedioxymethamphetamine (MDMA)
OT  - Flash evaporation-gas chromatography/mass spectrometry (FE-GC/MS)
OT  - Human hair
OT  - Ketamine (KET)
OT  - Methamphetamine (MAMP)
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/08/02 06:00
MHDA- 2021/03/23 06:00
CRDT- 2020/08/02 06:00
PHST- 2019/12/06 00:00 [received]
PHST- 2020/06/02 00:00 [revised]
PHST- 2020/07/12 00:00 [accepted]
PHST- 2020/08/02 06:00 [pubmed]
PHST- 2021/03/23 06:00 [medline]
PHST- 2020/08/02 06:00 [entrez]
AID - S1570-0232(19)31800-8 [pii]
AID - 10.1016/j.jchromb.2020.122275 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Sep 15;1153:122275. doi: 
      10.1016/j.jchromb.2020.122275. Epub 2020 Jul 16.