PMID- 32738905 OWN - NLM STAT- MEDLINE DCOM- 20210609 LR - 20210609 IS - 1476-7120 (Electronic) IS - 1476-7120 (Linking) VI - 18 IP - 1 DP - 2020 Aug 1 TI - Association between multi-site atherosclerotic plaques and systemic arteriosclerosis: results from the BEST study (Beijing Vascular Disease Patients Evaluation Study). PG - 30 LID - 10.1186/s12947-020-00212-3 [doi] LID - 30 AB - BACKGROUND: Arteriosclerosis can be reflected in various aspect of the artery, including atherosclerotic plaque formation or stiffening on the arterial wall. Both arteriosclerosis and atherosclerosis are important and closely associated with cardiovascular disease (CVD). The aim of the study was to evaluate the association between systemic arteriosclerosis and multi-site atherosclerotic plaques. METHODS: The study was designed as an observational cross-sectional study. A total of 1178 participants (mean age 67.4 years; 52.2% male) enrolled into the observational study from 2010 to 2017. Systemic arteriosclerosis was assessed by carotid femoral artery pulse wave velocity (CF-PWV) and multi-site atherosclerotic plaques (MAP, > = 2 of the below sites) were reflected in the carotid or subclavian artery, abdominal aorta and lower extremities arteries using ultrasound equipment. The associations were assessed by multivariable logistic regression. RESULTS: The prevalence of CF-PWV > 12 m/s and MAP were 40.2% and 74.4%. Atherosclerotic plaques in 3 sites were more common in male compared with that in female (48.9% versus 36.9%, p < 0.05). All CVD factors were worse in participants with MAP than that with <=1 site. Participants with CF-PWV > 12 m/s corresponded to a mean 82% probability of MAP with age and sex-adjusted. Patients with peripheral artery disease showed the highest odds ratio (OR) (3.88) for MAP, followed by smoking (2.485), CF-PWV > 12 m/s (2.25), dyslipidemia (1.89), male (1.84), stroke (1.64), hypoglycemic agents (1.56) and age (1.09) (all p < 0.001). CONCLUSIONS: MAP was highly prevalent in this cohort, with male showing a higher prevalence than female. Higher systemic arteriosclerosis was independently associated with MAP, which indicating the supplementary value of arteriosclerosis for the earlier identification and intervention on MAP. TRIAL REGISTRATION: Clinical Trial, URL: http://www.clinicaltrials.gov . Unique identifier: NCT02569268 . FAU - Liu, Huan AU - Liu H AD - Vascular Medicine Center, Peking University Shougang Hospital, NO. 9 Jinyuanzhuang Road, Shijingshan District, Beijing, China. AD - Vascular Health Research Center of Peking University Health Science Center, Beijing, China. FAU - Liu, Jinbo AU - Liu J AD - Vascular Medicine Center, Peking University Shougang Hospital, NO. 9 Jinyuanzhuang Road, Shijingshan District, Beijing, China. AD - Vascular Health Research Center of Peking University Health Science Center, Beijing, China. FAU - Huang, Wei AU - Huang W AD - Vascular Medicine Center, Peking University Shougang Hospital, NO. 9 Jinyuanzhuang Road, Shijingshan District, Beijing, China. FAU - Zhao, Hongwei AU - Zhao H AD - Vascular Medicine Center, Peking University Shougang Hospital, NO. 9 Jinyuanzhuang Road, Shijingshan District, Beijing, China. FAU - Zhao, Na AU - Zhao N AD - Vascular Medicine Center, Peking University Shougang Hospital, NO. 9 Jinyuanzhuang Road, Shijingshan District, Beijing, China. FAU - Wang, Hongyu AU - Wang H AD - Vascular Medicine Center, Peking University Shougang Hospital, NO. 9 Jinyuanzhuang Road, Shijingshan District, Beijing, China. dr.hongyuwang@foxmail.com. AD - Vascular Health Research Center of Peking University Health Science Center, Beijing, China. dr.hongyuwang@foxmail.com. AD - Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing, China. dr.hongyuwang@foxmail.com. AD - Peking University Clinical Research Institute, Beijing, China. dr.hongyuwang@foxmail.com. LA - eng SI - ClinicalTrials.gov/NCT02569268 GR - 2017YFC0113000/the National Key R&D Program of China/ GR - NQ2016-07/Capital project of scientific and technological development of traditional Chinese medicine in Beijing/ GR - 2017-hospital-clinical-01/Key clinical projects in Peking University Shougang Hospital/ GR - SGYYZ201610/Key clinical projects in Peking University Shougang Hospital/ GR - SGYYQ201605/Key clinical projects in Peking University Shougang Hospital/ GR - 2014-CXB-24/Medical innovation project of Fujian Province in 2014/ GR - 2011-4026-02/Capital's Funds for Health Improvement and Research/ PT - Journal Article DEP - 20200801 PL - England TA - Cardiovasc Ultrasound JT - Cardiovascular ultrasound JID - 101159952 SB - IM MH - Aged MH - Arteriosclerosis/*diagnosis/epidemiology/physiopathology MH - Beijing/epidemiology MH - Blood Flow Velocity/*physiology MH - Blood Pressure MH - Cross-Sectional Studies MH - Female MH - Follow-Up Studies MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Plaque, Atherosclerotic/*diagnosis/epidemiology/physiopathology MH - Prospective Studies MH - Risk Factors MH - Vascular Diseases/*diagnosis/epidemiology MH - *Vascular Stiffness PMC - PMC7395974 OTO - NOTNLM OT - Arteriosclerosis OT - Atherosclerosis OT - Atherosclerotic plaque OT - CF-PWV OT - Carotid femoral artery pulse wave velocity COIS- The authors declare that they have no competing interests. EDAT- 2020/08/03 06:00 MHDA- 2021/06/10 06:00 PMCR- 2020/08/01 CRDT- 2020/08/03 06:00 PHST- 2020/06/03 00:00 [received] PHST- 2020/07/24 00:00 [accepted] PHST- 2020/08/03 06:00 [entrez] PHST- 2020/08/03 06:00 [pubmed] PHST- 2021/06/10 06:00 [medline] PHST- 2020/08/01 00:00 [pmc-release] AID - 10.1186/s12947-020-00212-3 [pii] AID - 212 [pii] AID - 10.1186/s12947-020-00212-3 [doi] PST - epublish SO - Cardiovasc Ultrasound. 2020 Aug 1;18(1):30. doi: 10.1186/s12947-020-00212-3.