PMID- 32739425
OWN - NLM
STAT- MEDLINE
DCOM- 20210813
LR  - 20210813
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 160
DP  - 2020 Oct
TI  - Role of the neurovascular unit in the process of cerebral ischemic injury.
PG  - 105103
LID - S1043-6618(20)31411-0 [pii]
LID - 10.1016/j.phrs.2020.105103 [doi]
AB  - Cerebral ischemic injury exhibits both high morbidity and mortality worldwide. 
      Traditional research of the pathogenesis of cerebral ischemic injury has focused 
      on separate analyses of the involved cell types. In recent years, the 
      neurovascular unit (NVU) mechanism of cerebral ischemic injury has been proposed 
      in modern medicine. Hence, more effective strategies for the treatment of 
      cerebral ischemic injury may be provided through comprehensive analysis of brain 
      cells and the extracellular matrix. However, recent studies that have 
      investigated the function of the NVU in cerebral ischemic injury have been 
      insufficient. In addition, the metabolism and energy conversion of the NVU depend 
      on interactions among multiple cell types, which make it difficult to identify 
      the unique contribution of each cell type. Therefore, in the present review, we 
      comprehensively summarize the regulatory effects and recovery mechanisms of four 
      major cell types (i.e., astrocytes, microglia, brain-microvascular endothelial 
      cells, and neurons) in the NVU under cerebral ischemic injury, as well as discuss 
      the interactions among these cell types in the NVU. Furthermore, we discuss the 
      common signaling pathways and signaling factors that mediate cerebral ischemic 
      injury in the NVU, which may help to provide a theoretical basis for the 
      comprehensive elucidation of cerebral ischemic injury.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Zhao, Yu
AU  - Zhao Y
AD  - Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
FAU - Yang, Jiehong
AU  - Yang J
AD  - Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
FAU - Li, Chang
AU  - Li C
AD  - Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
FAU - Zhou, Guoying
AU  - Zhou G
AD  - Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
FAU - Wan, Haofang
AU  - Wan H
AD  - Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
FAU - Ding, Zhishan
AU  - Ding Z
AD  - Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China.
FAU - Wan, Haitong
AU  - Wan H
AD  - Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China. 
      Electronic address: whtong@126.com.
FAU - Zhou, Huifen
AU  - Zhou H
AD  - Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China. 
      Electronic address: zhouhuifen2320@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200731
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
SB  - IM
MH  - Animals
MH  - Blood Vessels/*innervation/*pathology
MH  - Blood-Brain Barrier
MH  - Brain Ischemia/*pathology
MH  - Endothelial Cells/pathology
MH  - Endothelium, Vascular/innervation/pathology
MH  - Humans
MH  - Neurons/*pathology
OTO - NOTNLM
OT  - Astrocytes
OT  - Brain microvascular endothelial cells
OT  - Cerebral ischemic injury
OT  - Microglia
OT  - Neurons
OT  - Neurovascular unit
EDAT- 2020/08/03 06:00
MHDA- 2021/08/14 06:00
CRDT- 2020/08/03 06:00
PHST- 2020/03/06 00:00 [received]
PHST- 2020/07/20 00:00 [revised]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/08/03 06:00 [pubmed]
PHST- 2021/08/14 06:00 [medline]
PHST- 2020/08/03 06:00 [entrez]
AID - S1043-6618(20)31411-0 [pii]
AID - 10.1016/j.phrs.2020.105103 [doi]
PST - ppublish
SO  - Pharmacol Res. 2020 Oct;160:105103. doi: 10.1016/j.phrs.2020.105103. Epub 2020 
      Jul 31.