PMID- 32739453
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 37
IP  - 2
DP  - 2021 Feb
TI  - Physical Functioning, Mental Health, and Quality of Life in Different Congenital 
      Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries.
PG  - 215-223
LID - S0828-282X(20)30317-2 [pii]
LID - 10.1016/j.cjca.2020.03.044 [doi]
AB  - BACKGROUND: We compared physical functioning, mental health, and quality of life 
      (QoL) of patients with different subtypes of congenital heart disease (CHD) in a 
      large international sample and investigated the role of functional class in 
      explaining the variance in outcomes across heart defects. METHODS: In the 
      cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with 
      Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 
      adult patients with CHD from 15 countries. Diagnostic groups with at least 50 
      patients were included in these analyses, yielding a sample of 3538 patients 
      (median age: 32 years; 52% women). Physical functioning, mental health, and QoL 
      were measured with the SF-12 health status survey, Hospital Anxiety and 
      Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life 
      Scale, respectively. Functional class was assessed using the patient-reported New 
      York Heart Association (NYHA) class. Multivariable general linear mixed models 
      were applied to assess the relationship between the type of CHD and 
      patient-reported outcomes, adjusted for patient characteristics, and with country 
      as random effect. RESULTS: Patients with coarctation of the aorta and those with 
      isolated aortic valve disease reported the best physical functioning, mental 
      health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had 
      worst outcomes. The differences were statistically significant, above and beyond 
      other patient characteristics. However, the explained variances were small (0.6% 
      to 4.1%) and decreased further when functional status was added to the models 
      (0.4% to 0.9%). CONCLUSIONS: Some types of CHD predict worse patient-reported 
      outcomes. However, it appears that it is the functional status associated with 
      the heart defect rather than the heart defect itself that shapes the outcomes.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Moons, Philip
AU  - Moons P
AD  - KU Leuven Department of Public Health and Primary Care, KU Leuven, Leuven, 
      Belgium; Institute of Health and Care Sciences, University of Gothenburg, 
      Gothenburg, Sweden; Centre for Person-Centred Care (GPCC), University of 
      Gothenburg, Gothenburg, Sweden; Department of Paediatrics and Child Health, 
      University of Cape Town, Cape Town, South Africa. Electronic address: 
      philip.moons@kuleuven.be.
FAU - Luyckx, Koen
AU  - Luyckx K
AD  - KU Leuven School Psychology and Development in Context, KU Leuven, Leuven, 
      Belgium; UNIBS, University of the Free State, Bloemfontein, South Africa.
FAU - Thomet, Corina
AU  - Thomet C
AD  - KU Leuven Department of Public Health and Primary Care, KU Leuven, Leuven, 
      Belgium; Center for Congenital Heart Disease, Department of Cardiology, 
      Inselspital-Bern University Hospital, University of Bern, Bern, Switzerland.
FAU - Budts, Werner
AU  - Budts W
AD  - Division of Congenital and Structural Cardiology, University Hospitals Leuven, 
      Leuven, Belgium; KU Leuven Department of Cardiovascular Sciences, KU Leuven, 
      Leuven, Belgium.
FAU - Enomoto, Junko
AU  - Enomoto J
AD  - Department of Education, Toyo University, Tokyo, Japan.
FAU - Sluman, Maayke A
AU  - Sluman MA
AD  - Coronel Institute of Occupational Health, Amsterdam UMC, University of Amsterdam, 
      Amsterdam, The Netherlands; Department of Cardiology, Jeroen Bosch Hospital, 's 
      Hertogenbosch, The Netherlands.
FAU - Lu, Chun-Wei
AU  - Lu CW
AD  - Adult Congenital Heart Center, Department of Pediatrics, National Taiwan 
      University Children's Hospital, Taipei, Taiwan.
FAU - Jackson, Jamie L
AU  - Jackson JL
AD  - Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, Ohio, 
      USA.
FAU - Khairy, Paul
AU  - Khairy P
AD  - Adult Congenital Heart Center, Montreal Heart Institute, Universite de Montreal, 
      Quebec, Canada.
FAU - Cook, Stephen C
AU  - Cook SC
AD  - Adult Congenital Heart Disease Center, Helen DeVos Children's Hospital, Grand 
      Rapids, Michigan, USA.
FAU - Chidambarathanu, Shanthi
AU  - Chidambarathanu S
AD  - Pediatric Cardiology, Frontier Lifeline Hospital (Dr K. M. Cherian Heart 
      Foundation), Chennai, India.
FAU - Alday, Luis
AU  - Alday L
AD  - Division of Cardiology, Hospital de Ninos, Cordoba, Argentina.
FAU - Eriksen, Katrine
AU  - Eriksen K
AD  - Adult Congenital Heart Disease Center, Oslo University Hospital-Rikshospitalet, 
      Oslo, Norway.
FAU - Dellborg, Mikael
AU  - Dellborg M
AD  - Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, 
      Sweden; Adult Congenital Heart Unit, Sahlgrenska University Hospital/Ostra, 
      Gothenburg, Sweden; Institute of Medicine, The Sahlgrenska Academy at University 
      of Gothenburg, Sweden.
FAU - Berghammer, Malin
AU  - Berghammer M
AD  - Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, 
      Sweden; Department of Health Sciences, University West, Trollhattan, Sweden; 
      Department of Paediatrics, Queen Silvia Children's Hospital, Sahlgrenska 
      University Hospital, Gothenburg, Sweden.
FAU - Johansson, Bengt
AU  - Johansson B
AD  - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
FAU - Mackie, Andrew S
AU  - Mackie AS
AD  - Division of Cardiology, Stollery Children's Hospital, University of Alberta, 
      Edmonton, Alberta, Canada.
FAU - Menahem, Samuel
AU  - Menahem S
AD  - Monash Heart, Monash Medical Centre, Monash University, Melbourne, Australia.
FAU - Caruana, Maryanne
AU  - Caruana M
AD  - Department of Cardiology, Mater Dei Hospital, Birkirkara Bypass, Malta.
FAU - Veldtman, Gruschen
AU  - Veldtman G
AD  - Adult Congenital Heart Disease Center, Cincinnati Children's Hospital Medical 
      Center, Cincinnati, Ohio, USA.
FAU - Soufi, Alexandra
AU  - Soufi A
AD  - Department of Congenital Heart Disease, Louis Pradel Hospital, Hospices civils de 
      Lyon, Lyon, France.
FAU - Fernandes, Susan M
AU  - Fernandes SM
AD  - Adult Congenital Heart Disease Program at Stanford, Lucile Packard Children's 
      Hospital and Stanford Health Care, Palo Alto, California, USA.
FAU - White, Kamila
AU  - White K
AD  - Adult Congenital Heart Disease Center, Washington University and Barnes Jewish 
      Heart & Vascular Center, University of Missouri, St Louis, Missouri, USA.
FAU - Callus, Edward
AU  - Callus E
AD  - Clinical Psychology Service, IRCCS Policlinico San Donato, Milan, Italy; 
      Department of Biomedical Sciences for Health, Universita degli Studi di Milano, 
      Milan, Italy.
FAU - Kutty, Shelby
AU  - Kutty S
AD  - Adult Congenital Heart Disease Center University of Nebraska Medical 
      Center/Children's Hospital and Medical Center, Omaha, Nebraska, USA; Taussig 
      Heart Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
FAU - Ombelet, Fouke
AU  - Ombelet F
AD  - KU Leuven Department of Public Health and Primary Care, KU Leuven, Leuven, 
      Belgium.
FAU - Apers, Silke
AU  - Apers S
AD  - KU Leuven Department of Public Health and Primary Care, KU Leuven, Leuven, 
      Belgium.
FAU - Kovacs, Adrienne H
AU  - Kovacs AH
AD  - Peter Munk Cardiac Centre, University Health Network, University of Toronto, 
      Toronto, Ontario, Canada; Knight Cardiovascular Institute, Oregon Health & 
      Science University, Portland, Oregon, USA.
CN  - APPROACH-IS Consortium and the International Society for Adult Congenital Heart 
      Disease (ISACHD)
LA  - eng
SI  - ClinicalTrials.gov/NCT02150603
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200406
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
SB  - IM
CIN - Can J Cardiol. 2021 Feb;37(2):186-187. PMID: 32339650
MH  - Adult
MH  - Aftercare/statistics & numerical data
MH  - Correlation of Data
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Functional Status
MH  - Global Health/*statistics & numerical data
MH  - Health Status Disparities
MH  - *Heart Defects, Congenital/classification/epidemiology/psychology/therapy
MH  - Humans
MH  - Male
MH  - *Mental Health
MH  - *Patient Reported Outcome Measures
MH  - Physical Functional Performance
MH  - *Quality of Life
EDAT- 2020/08/03 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/08/03 06:00
PHST- 2020/02/13 00:00 [received]
PHST- 2020/03/28 00:00 [revised]
PHST- 2020/03/29 00:00 [accepted]
PHST- 2020/08/03 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/08/03 06:00 [entrez]
AID - S0828-282X(20)30317-2 [pii]
AID - 10.1016/j.cjca.2020.03.044 [doi]
PST - ppublish
SO  - Can J Cardiol. 2021 Feb;37(2):215-223. doi: 10.1016/j.cjca.2020.03.044. Epub 2020 
      Apr 6.