PMID- 32739615
OWN - NLM
STAT- MEDLINE
DCOM- 20211130
LR  - 20220202
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Print)
IS  - 1526-5900 (Linking)
VI  - 22
IP  - 2
DP  - 2021 Feb
TI  - Injectable PLGA-Coated Ropivacaine Produces A Long-Lasting Analgesic Effect on 
      Incisional Pain and Neuropathic Pain.
PG  - 180-195
LID - S1526-5900(20)30058-4 [pii]
LID - 10.1016/j.jpain.2020.03.009 [doi]
AB  - The management of persistent postsurgical pain and neuropathic pain remains a 
      challenge in the clinic. Local anesthetics have been widely used as simple and 
      effective treatment for these 2 disorders, but the duration of their analgesic 
      effect is short. We here reported a new poly lactic-co-glycolic acid 
      (PLGA)-coated ropivacaine that was continuously released in vitro for at least 6 
      days. Perisciatic nerve injection of the PLGA-coated ropivacaine attenuated paw 
      incision-induced mechanical allodynia and heat hyperalgesia during the incisional 
      pain period, and spared nerve injury-induced mechanical and cold allodynia for at 
      least 7 days postinjection. This effect was dose-dependent. Perisciatic nerve 
      injection of the PLGA-coated ropivacaine did not produce detectable inflammation, 
      tissue irritation, or damage in the sciatic nerve and surrounding muscles at the 
      injected site, dorsal root ganglion, spinal cord, or brain cortex, although the 
      scores for grasping reflex were mildly and transiently reduced in the higher 
      dosage-treated groups. PERSPECTIVE: Given that PLGA is an FDA-approved medical 
      material, and that ropivacaine is used currently in clinical practice, the 
      injectable PLGA-coated ropivacaine represents a new and highly promising avenue 
      in the management of postsurgical pain and neuropathic pain.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Tian, Xue
AU  - Tian X
AD  - Department of Anesthesiology, New Jersey Medical School, Rutgers, The State 
      University of New Jersey, Newark, New Jersey; Department of Anesthesiology, 
      Peking University People's Hospital, Beijing, China.
FAU - Zhu, He
AU  - Zhu H
AD  - Department of Chemical and Materials Engineering, New Jersey Institute of 
      Technology, Newark, New Jersey.
FAU - Du, Shibin
AU  - Du S
AD  - Department of Anesthesiology, New Jersey Medical School, Rutgers, The State 
      University of New Jersey, Newark, New Jersey.
FAU - Zhang, Xue-Qing
AU  - Zhang XQ
AD  - Engineering Research Center of Cell & Therapeutic Antibody Ministry of Education, 
      School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
FAU - Lin, Fuqing
AU  - Lin F
AD  - Department of Anesthesiology, New Jersey Medical School, Rutgers, The State 
      University of New Jersey, Newark, New Jersey.
FAU - Ji, Fengtao
AU  - Ji F
AD  - Department of Anesthesiology, New Jersey Medical School, Rutgers, The State 
      University of New Jersey, Newark, New Jersey.
FAU - Tsou, Yung-Hao
AU  - Tsou YH
AD  - Department of Chemical and Materials Engineering, New Jersey Institute of 
      Technology, Newark, New Jersey.
FAU - Li, Zhongyu
AU  - Li Z
AD  - Department of Chemical and Materials Engineering, New Jersey Institute of 
      Technology, Newark, New Jersey.
FAU - Feng, Yi
AU  - Feng Y
AD  - Department of Anesthesiology, Peking University People's Hospital, Beijing, 
      China.
FAU - Ticehurst, Kathryn
AU  - Ticehurst K
AD  - Department of Anesthesiology, New Jersey Medical School, Rutgers, The State 
      University of New Jersey, Newark, New Jersey.
FAU - Hannaford, Stephen
AU  - Hannaford S
AD  - Department of Anesthesiology, New Jersey Medical School, Rutgers, The State 
      University of New Jersey, Newark, New Jersey.
FAU - Xu, Xiaoyang
AU  - Xu X
AD  - Department of Chemical and Materials Engineering, New Jersey Institute of 
      Technology, Newark, New Jersey; Department of Biomedical Engineering, New Jersey 
      Institute of Technology, Newark, New Jersey.
FAU - Tao, Yuan-Xiang
AU  - Tao YX
AD  - Department of Anesthesiology, New Jersey Medical School, Rutgers, The State 
      University of New Jersey, Newark, New Jersey. Electronic address: 
      yuanxiang.tao@njms.rutgers.edu.
LA  - eng
GR  - UL1 TR003017/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200730
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
RN  - 0 (Anesthetics, Local)
RN  - 0 (Biocompatible Materials)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 7IO5LYA57N (Ropivacaine)
SB  - IM
MH  - Anesthetics, Local/*administration & dosage
MH  - Animals
MH  - *Biocompatible Materials
MH  - Disease Models, Animal
MH  - Drug Delivery Systems
MH  - Hyperalgesia/etiology/prevention & control
MH  - Male
MH  - Neuralgia/*drug therapy/etiology
MH  - Pain, Postoperative/*drug therapy/etiology
MH  - *Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ropivacaine/*administration & dosage
MH  - Sciatic Nerve
PMC - PMC7855452
MID - NIHMS1617078
OTO - NOTNLM
OT  - Microparticles
OT  - long-lasting analgesia
OT  - neuropathic pain
OT  - poly lactic-co-glycolic acid
OT  - postsurgical pain
OT  - ropivacaine
COIS- Conflicts of interests The authors declare no competing interests.
EDAT- 2020/08/03 06:00
MHDA- 2021/12/01 06:00
PMCR- 2022/02/01
CRDT- 2020/08/03 06:00
PHST- 2019/07/22 00:00 [received]
PHST- 2020/02/27 00:00 [revised]
PHST- 2020/03/22 00:00 [accepted]
PHST- 2020/08/03 06:00 [pubmed]
PHST- 2021/12/01 06:00 [medline]
PHST- 2020/08/03 06:00 [entrez]
PHST- 2022/02/01 00:00 [pmc-release]
AID - S1526-5900(20)30058-4 [pii]
AID - 10.1016/j.jpain.2020.03.009 [doi]
PST - ppublish
SO  - J Pain. 2021 Feb;22(2):180-195. doi: 10.1016/j.jpain.2020.03.009. Epub 2020 Jul 
      30.