PMID- 32739682
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 156
DP  - 2020 Oct 15
TI  - Equine endometrial development during late fetal and postnatal periods.
PG  - 155-161
LID - S0093-691X(20)30356-3 [pii]
LID - 10.1016/j.theriogenology.2020.06.006 [doi]
AB  - Equine uterine development, including endometrial histogenesis, begins prenatally 
      and is completed postnatally. Little is known about this process in the horse. 
      Uterine tissue was acquired from 38 foals, ranging in developmental age from 
      gestational day (GD) 300 to postnatal day (PND) 180, for assessment of 
      endometrial histogenesis. Patterns of endometrial cell proliferation were 
      evaluated by multispectral imaging of uterine tissue sections stained 
      immunofluorescently for Ki-67. Labeling index (LI, % labeled cells) for Ki-67 was 
      calculated for each endometrial cell compartment (luminal epithelium, glandular 
      epithelium, stroma). Histologically, nascent endometrial glands were present in 
      all pre- and postnatal uterine tissues. Overall, Ki-67 LI increased (P < 0.0001) 
      from the pre-to postnatal periods, and was higher (P < 0.0001) in epithelium as 
      compared to stroma. Postnatally, endometrial Ki-67 LI increased (P < 0.0001) from 
      week 1 to week 24. Our findings confirm that, in contrast to neonatal patterns of 
      uterine development described for domestic ungulates, equine endometrial 
      histogenesis begins prenatally, marked by the appearance of uterine glands as 
      early as GD 300. Epithelial proliferation associated with maturation of the 
      equine endometrium is pronounced by postnatal week 24.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Fraser, Natalie S
AU  - Fraser NS
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, Auburn, AL, USA.
FAU - Wilborn, Robyn R
AU  - Wilborn RR
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, Auburn, AL, USA. Electronic address: wilborn@auburn.edu.
FAU - Johnson, Amie K
AU  - Johnson AK
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Auburn 
      University, Auburn, AL, USA.
FAU - Braden, Timothy D
AU  - Braden TD
AD  - Department of Anatomy, Physiology, and Pharmacology, Cellular and Molecular 
      Biosciences Program, Auburn University, Auburn, AL, USA.
FAU - Wiley, Anne A
AU  - Wiley AA
AD  - Department of Anatomy, Physiology, and Pharmacology, Cellular and Molecular 
      Biosciences Program, Auburn University, Auburn, AL, USA.
FAU - Canisso, Igor F
AU  - Canisso IF
AD  - Department of Veterinary Clinical Medicine, College of Veterinary Medicine, 
      University of Illinois Urbana-Champaign, Urbana, IL, USA.
FAU - Bartol, Frank F
AU  - Bartol FF
AD  - Department of Anatomy, Physiology, and Pharmacology, Cellular and Molecular 
      Biosciences Program, Auburn University, Auburn, AL, USA.
LA  - eng
PT  - Journal Article
DEP - 20200610
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - *Endometrium
MH  - Epithelium
MH  - Female
MH  - Fetus
MH  - Horses
MH  - *Uterus
OTO - NOTNLM
OT  - Development
OT  - Endometrium
OT  - Equine
OT  - Fetal
OT  - Neonatal
COIS- Declaration of competing interest None.
EDAT- 2020/08/03 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/08/03 06:00
PHST- 2020/03/31 00:00 [received]
PHST- 2020/06/08 00:00 [accepted]
PHST- 2020/08/03 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/08/03 06:00 [entrez]
AID - S0093-691X(20)30356-3 [pii]
AID - 10.1016/j.theriogenology.2020.06.006 [doi]
PST - ppublish
SO  - Theriogenology. 2020 Oct 15;156:155-161. doi: 
      10.1016/j.theriogenology.2020.06.006. Epub 2020 Jun 10.