PMID- 32740671 OWN - NLM STAT- MEDLINE DCOM- 20201221 LR - 20201221 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) VI - 41 IP - 8 DP - 2020 Dec TI - Effect of General Anesthesia on Cardiac Magnetic Resonance-Derived Cardiac Function in Repaired Tetralogy of Fallot. PG - 1660-1666 LID - 10.1007/s00246-020-02425-9 [doi] AB - Cardiac magnetic resonance imaging (CMR)-derived ejection fraction (EF) predicts adverse outcomes in repaired tetralogy of Fallot (rTOF) and drives timing of pulmonary valve replacement. Certain patient populations require sedation for successful CMR image acquisition. General anesthesia (GA) has been shown to depress EF and heart rate (HR) in animal models, however, its effect on congenital heart disease is unknown. A retrospective review was conducted of all CMR patients referred with rTOF between January 2011 and May 2019. The cohort was separated into GA and non-GA groups. Propensity score matching (PSM) adjusted for selection bias. A kernel matching algorithm was used to match subjects and the differences in mean treatment effect on the treated were computed for left ventricular (LV) and right ventricular (RV) EF, HR, and cardiac index (CI). 143 patients met criteria, 37 patients under GA (mean age 15 years, range 2-45, 59% male), and 106 patients without GA (mean age 21 years, range 10-53, 50% male). Unmatched analysis showed significant depression of LV EF (50 vs. 57%, p < 0.001) and RV EF (42 vs. 48%, p < 0.001) in the GA group compared to the non-GA group. There was no significant difference in HR or CI. After matching and PSM adjustment, the GA group had a significant decrease in LV EF (49 vs. 56%, p < 0.001), RV EF (41 vs. 48%, p < 0.001), CI (2728 vs. 3701 ml/min/m(2), p < 0.001), and HR (72 vs. 79 bpm, p = 0.04). General anesthesia with sevoflurane results in depressed CMR-derived EF. FAU - Muyskens, Steve AU - Muyskens S AUID- ORCID: 0000-0001-9515-4050 AD - Department of Pediatric Cardiology, Cook Children's Medical Center, 1500 Cooper Street, 3rd Floor, Fort Worth, TX, 76104, USA. steve.muyskens@cookchildrens.org. FAU - Roshan, Tony AU - Roshan T AD - University of North Texas Health Science Center, Texas College of Osteopathic Medicine, Fort Worth, TX, USA. FAU - Honan, Kevin AU - Honan K AD - University of North Texas Health Science Center, Texas College of Osteopathic Medicine, Fort Worth, TX, USA. FAU - Umejiego, Johnbosco AU - Umejiego J AD - Department of Research Operations, Cook Children's Medical Center, Fort Worth, TX, USA. FAU - Raynaud, Scott AU - Raynaud S AD - Department of Research Operations, Cook Children's Medical Center, Fort Worth, TX, USA. FAU - Ogunyankin, Fadeke AU - Ogunyankin F AD - Department of Research Operations, Cook Children's Medical Center, Fort Worth, TX, USA. LA - eng PT - Journal Article DEP - 20200801 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 RN - 0 (Anesthetics, Inhalation) RN - 38LVP0K73A (Sevoflurane) SB - IM MH - Adolescent MH - Adult MH - Anesthesia, General/*methods MH - Anesthetics, Inhalation/therapeutic use MH - Cardiac Surgical Procedures/methods MH - Child MH - Child, Preschool MH - Female MH - Heart Ventricles/diagnostic imaging MH - Humans MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Propensity Score MH - Retrospective Studies MH - Sevoflurane/*therapeutic use MH - Stroke Volume/*drug effects MH - Tetralogy of Fallot/*diagnostic imaging/surgery MH - Ventricular Function, Left/drug effects MH - Ventricular Function, Right/drug effects MH - Young Adult OTO - NOTNLM OT - Cardiac MRI OT - General anesthesia OT - Tetralogy of fallot EDAT- 2020/08/03 06:00 MHDA- 2020/12/22 06:00 CRDT- 2020/08/03 06:00 PHST- 2020/04/15 00:00 [received] PHST- 2020/07/21 00:00 [accepted] PHST- 2020/08/03 06:00 [pubmed] PHST- 2020/12/22 06:00 [medline] PHST- 2020/08/03 06:00 [entrez] AID - 10.1007/s00246-020-02425-9 [pii] AID - 10.1007/s00246-020-02425-9 [doi] PST - ppublish SO - Pediatr Cardiol. 2020 Dec;41(8):1660-1666. doi: 10.1007/s00246-020-02425-9. Epub 2020 Aug 1.