PMID- 32740818
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20210414
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Print)
IS  - 0938-7994 (Linking)
VI  - 31
IP  - 1
DP  - 2021 Jan
TI  - Comparison of postoperative CT- and preoperative MRI-based breast tumor bed 
      contours in prone position for radiotherapy after breast-conserving surgery.
PG  - 345-355
LID - 10.1007/s00330-020-07085-0 [doi]
AB  - OBJECTIVES: To compare the target volume of tumor bed defined by postoperative 
      computed tomography (post-CT) in prone position registered with or without 
      preoperative magnetic resonance imaging (pre-MRI). METHODS: A total of 22 
      patients were included with early-stage breast invasive ductal cancer, who have 
      undergone breast-conservative surgery and received the pre-MRI and post-CT in 
      prone position. The MRI sequences (T1W, T2W, T2W-SPAIR, DWI, dyn-eTHRIVE, 
      sdyn-eTHRIVE) were delineated and manually registered to CT, respectively. The 
      clinical target volumes (CTVs) and planning target volumes (PTVs) were contoured 
      on CT and different MRI sequences, respectively. Differences were measured in 
      terms of consistence index (CI), dice coefficient (DC), geographical miss index 
      (GMI), and normal tissue index (NTI). RESULTS: The differences of delineation 
      volumes among CT and MRIs were significant, both in the CTVs (p = 0.035) and PTVs 
      (p < 0.001). The values of CI and DC for sdyn-eTHRIVE registration to CT were the 
      largest among all MRI sequences, but GMI and NTI were the smallest. No obvious 
      linear correlation (p > 0.05) between the CI derived from the registration of CT 
      and sdyn-eTHRIVE of CTV with the breast volume, the cavity visualization 
      score (CVS) of CT, time interval from surgery to CT simulation, the maximum 
      diameter of the intraoperative mass, and the number of titanium clips, 
      respectively. CONCLUSIONS: The CTVs and PTVs in MRI sequences were all smaller 
      than those in CT. The pre-MRI, especially the sdyn-eTHRIVE, could be used to 
      optimize the post-CT-based target delineation of breast cancer. KEY POINTS: * 
      Registered pre-MRI to post-CT in order to improve the accuracy of target volume 
      delineation of breast cancer. * The CTVs and PTVs in MRI sequences were all 
      smaller than those in CT. * The sdyn-eTHRIVE of pre-MRIs may be a better choice 
      to improve the delineation of CT-based CTV and PTV.
FAU - Dong, Yinping
AU  - Dong Y
AD  - School of Medicine and Life Sciences, University of Jinan-Shandong Academy of 
      Medical Sciences, Jinan, China.
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 440 
      Jiyan Road, Jinan, 250117, Shandong, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 
      China.
FAU - Chen, Jinhu
AU  - Chen J
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 440 
      Jiyan Road, Jinan, 250117, Shandong, China.
FAU - Li, Wanhu
AU  - Li W
AD  - Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First 
      Medical University and Shandong Academy of Medical Sciences, Jinan, China.
FAU - Li, Yongqing
AU  - Li Y
AD  - Department of Surgical Ward 1, Shandong Cancer Hospital and Institute, Shandong 
      First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
FAU - Zhao, Qian
AU  - Zhao Q
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 440 
      Jiyan Road, Jinan, 250117, Shandong, China.
FAU - Chen, Yiru
AU  - Chen Y
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 440 
      Jiyan Road, Jinan, 250117, Shandong, China.
FAU - Huang, Wei
AU  - Huang W
AD  - Department of Radiation Oncology, Shandong Cancer Hospital and Institute, 
      Shandong First Medical University and Shandong Academy of Medical Sciences, 440 
      Jiyan Road, Jinan, 250117, Shandong, China. alvinbird@126.com.
LA  - eng
GR  - 81773232/National Natural Science Foundation of China/
GR  - 2020RC002/Academic promotion program of Shandong First Medical University/
GR  - tsqn201909187/Foundation of Young Taishan Scholars Program/
PT  - Journal Article
DEP - 20200801
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - *Breast Neoplasms/diagnostic imaging/radiotherapy/surgery
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Mastectomy, Segmental
MH  - Prone Position
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Tomography, X-Ray Computed
PMC - PMC7755637
OTO - NOTNLM
OT  - Breast cancer
OT  - Magnetic resonance imaging
OT  - Radiotherapy
COIS- The authors of this manuscript declare no relationships with any companies, whose 
      products or services may be related to the subject matter of the article.
EDAT- 2020/08/03 06:00
MHDA- 2021/04/15 06:00
PMCR- 2020/08/01
CRDT- 2020/08/03 06:00
PHST- 2020/04/17 00:00 [received]
PHST- 2020/07/20 00:00 [accepted]
PHST- 2020/05/15 00:00 [revised]
PHST- 2020/08/03 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2020/08/03 06:00 [entrez]
PHST- 2020/08/01 00:00 [pmc-release]
AID - 10.1007/s00330-020-07085-0 [pii]
AID - 7085 [pii]
AID - 10.1007/s00330-020-07085-0 [doi]
PST - ppublish
SO  - Eur Radiol. 2021 Jan;31(1):345-355. doi: 10.1007/s00330-020-07085-0. Epub 2020 
      Aug 1.