PMID- 32741208
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20220307
IS  - 1369-1619 (Electronic)
IS  - 0960-3123 (Linking)
VI  - 32
IP  - 4
DP  - 2022 Apr
TI  - Cognition impairment of rat in undersea environment.
PG  - 829-839
LID - 10.1080/09603123.2020.1799955 [doi]
AB  - This study was designed to examine the cognitive responses of rat simulation 
      model of the undersea environment. Rats were randomized into five groups: 
      control, restraint, hyperbaric air, restraint with hyperbaric air, and restraint 
      with hyperbaric air and immersion The cognition functions were assessed by Morris 
      water maze test and forced swimming test. The cerebral blood flow (CBF) was 
      monitored. The parameters examined were total antioxidant capacity (TAC), 
      superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), 
      glutathione (GSH), glutathione reductase (GR), and malondialdehyde (MDA). It was 
      observed that the rats in the experimental groups had impaired learning and 
      memory and behavioral despair accompanied by increase in CBF and MDA levels but 
      decrease of TAC, SOD, CAT, GSH-px, GSH, and GR levels. These indicated that the 
      simulated underwater conditions might cause immediate and transient cognition 
      impairment in the rat models. The simulated environment induced oxidative stress 
      led to the negative cognitive changes.
FAU - Zou, Yingxin
AU  - Zou Y
AD  - Naval Medical Center of PLA, Shanghai, China.
FAU - Tang, Ying
AU  - Tang Y
AUID- ORCID: 0000-0003-3451-4141
AD  - Naval Medical Center of PLA, Shanghai, China.
FAU - Fan, Wei
AU  - Fan W
AD  - Naval Medical Center of PLA, Shanghai, China.
FAU - Liu, Lina
AU  - Liu L
AD  - Naval Medical Center of PLA, Shanghai, China.
FAU - Jiao, Yong
AU  - Jiao Y
AD  - Naval Medical Center of PLA, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20200802
PL  - England
TA  - Int J Environ Health Res
JT  - International journal of environmental health research
JID - 9106628
RN  - 0 (Antioxidants)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - *Antioxidants
MH  - Cognition
MH  - Glutathione Peroxidase/metabolism
MH  - Malondialdehyde
MH  - Oxidative Stress
MH  - Rats
MH  - *Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - Cognition
OT  - diving
OT  - oxidative stress
OT  - underwater
EDAT- 2020/08/04 06:00
MHDA- 2022/03/08 06:00
CRDT- 2020/08/04 06:00
PHST- 2020/08/04 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
PHST- 2020/08/04 06:00 [entrez]
AID - 10.1080/09603123.2020.1799955 [doi]
PST - ppublish
SO  - Int J Environ Health Res. 2022 Apr;32(4):829-839. doi: 
      10.1080/09603123.2020.1799955. Epub 2020 Aug 2.