PMID- 32741781
OWN - NLM
STAT- MEDLINE
DCOM- 20230703
LR  - 20230703
IS  - 1878-4429 (Electronic)
IS  - 1878-4429 (Linking)
VI  - 16
IP  - 2
DP  - 2023
TI  - Use of hyperbaric oxygen therapy of purpura fulminans in an extremely low birth 
      weight preterm: A case report.
PG  - 339-342
LID - 10.3233/NPM-200428 [doi]
AB  - Purpura fulminans (PF) is a rare and fatal complication of septic shock or 
      diffuse intravascular coagulation (DIC) resulting in skin and soft tissue 
      necrosis. PF can be caused by congenital or acquired protein C (PC) or protein S 
      (PS) deficiency. The most common cause of PF in a neonate is sepsis. In our 
      extremely low birth weight preterm case, due to PF that started in the right-hand 
      fingers, examination was made and protein S deficiency was detected as well as 
      MTHFR (A1298C) and Factor V Leiden (R506Q) homozygous mutations. While being 
      unresponsive to fresh frozen plasma (FFP) and unfractionated heparin (UFH) 
      therapy, we want to highlight the curative treatment with hyperbaric oxygen 
      (HBOT), which has not previously been used in extremely low birth weight preterm 
      infants for this purpose.
FAU - Yilmaz, A
AU  - Yilmaz A
AD  - Department of Neonatology, Cerrahpasa Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Kaya, N
AU  - Kaya N
AD  - Department of Neonatology, Cerrahpasa Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Meric, R
AU  - Meric R
AD  - Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Bayramli, Z
AU  - Bayramli Z
AD  - Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Oroglu, B
AU  - Oroglu B
AD  - Istanbul Faculty of Medicine, Underwater and Hyperbaric Medicine Department, 
      Istanbul University, Istanbul, Turkey.
FAU - Celkan, T T
AU  - Celkan TT
AD  - Department of Pediatric Hematology and Oncology, Cerrahpasa Medical Faculty, 
      Istanbul University, Istanbul, Turkey.
FAU - Vural, M
AU  - Vural M
AD  - Department of Neonatology, Cerrahpasa Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Perk, Y
AU  - Perk Y
AD  - Department of Neonatology, Cerrahpasa Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - J Neonatal Perinatal Med
JT  - Journal of neonatal-perinatal medicine
JID - 101468335
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Infant
MH  - Humans
MH  - Infant, Newborn
MH  - *Purpura Fulminans/therapy/complications/genetics
MH  - *Hyperbaric Oxygenation
MH  - Heparin
MH  - Infant, Extremely Low Birth Weight
MH  - Infant, Premature
OTO - NOTNLM
OT  - Purpura fulminans
OT  - hyperbaric oxygen therapy
OT  - preterm
EDAT- 2020/08/04 06:00
MHDA- 2023/07/03 06:41
CRDT- 2020/08/04 06:00
PHST- 2023/07/03 06:41 [medline]
PHST- 2020/08/04 06:00 [pubmed]
PHST- 2020/08/04 06:00 [entrez]
AID - NPM200428 [pii]
AID - 10.3233/NPM-200428 [doi]
PST - ppublish
SO  - J Neonatal Perinatal Med. 2023;16(2):339-342. doi: 10.3233/NPM-200428.