PMID- 32742252
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 14
DP  - 2020
TI  - Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer's 
      Disease.
PG  - 693
LID - 10.3389/fnins.2020.00693 [doi]
LID - 693
AB  - Cyclooxygenases (COX) are enzymes catalyzing arachidonic acid into prostanoids. 
      COX exists in three isoforms: COX-1, 2, and 3. COX-1 and COX-2 have been widely 
      studied in order to explore and understand their involvement in Alzheimer's 
      disease (AD), a progressive neuroinflammatory dementia. COX-2 was traditionally 
      viewed to be expressed only under pathological conditions and to have detrimental 
      effects in AD pathophysiology and neurodegeneration. However, an increasing 
      number of reports point to much more complex roles of COX-2 in AD. 
      Mammalian/mechanistic target of rapamycin (mTOR) has been considered as a hub 
      which integrates multiple signaling cascades, some of which are also involved in 
      AD progression. COX-2 and mTOR are both involved in environmental sensing, 
      growth, and metabolic processes of the cell. They are also known to act in 
      cooperation in many different cancers and thus, their role together in normal 
      cellular functions as well as AD has been explored in this review. Some of the 
      therapeutic approaches targeting COX-2 and mTOR in AD and cancer are also 
      discussed.
CI  - Copyright (c) 2020 Tyagi, Kamal and Poddar.
FAU - Tyagi, Arti
AU  - Tyagi A
AD  - Department of Biochemical Engineering and Biotechnology, Indian Institute of 
      Technology Delhi, New Delhi, India.
FAU - Kamal, Mohammad A
AU  - Kamal MA
AD  - King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi 
      Arabia.
AD  - Enzymoics, Hebersham, NSW, Australia.
FAU - Poddar, Nitesh Kumar
AU  - Poddar NK
AD  - Department of Biosciences, Manipal University Jaipur, Jaipur, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200709
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC7364283
OTO - NOTNLM
OT  - Alzheimer's
OT  - COX
OT  - cellular pathways
OT  - mTOR
OT  - neuro-inflammatory
EDAT- 2020/08/04 06:00
MHDA- 2020/08/04 06:01
PMCR- 2020/01/01
CRDT- 2020/08/04 06:00
PHST- 2020/02/12 00:00 [received]
PHST- 2020/06/08 00:00 [accepted]
PHST- 2020/08/04 06:00 [entrez]
PHST- 2020/08/04 06:00 [pubmed]
PHST- 2020/08/04 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2020.00693 [doi]
PST - epublish
SO  - Front Neurosci. 2020 Jul 9;14:693. doi: 10.3389/fnins.2020.00693. eCollection 
      2020.