PMID- 32744416
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20220317
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 52
IP  - 2
DP  - 2022 Feb
TI  - Optimal management of blood glucose, blood pressure and atrial fibrillation to 
      reduce the risk of heart failure with preserved ejection fraction.
PG  - 301-309
LID - 10.1111/imj.15006 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM), hypertension and atrial fibrillation 
      (AF) are risk factors for heart failure with preserved ejection fraction (HFpEF). 
      AIM: To examine the effects of the simultaneous control of all three conditions 
      on new-onset HFpEF in this population. METHODS: This prospective cohort study 
      enrolled 552 patients with T2DM, hypertension and AF, but without clinical signs 
      or symptoms of heart failure. The participants were followed up for 5 years to 
      examine the effects of glycaemic control (haemoglobin A1c: <7.0%, 7.0%-8.0% and 
      >8.0%), blood pressure (BP) control (systolic BP: <120, 120-140 and >140 mmHg) or 
      rhythm versus rate control for AF on new-onset HFpEF. RESULTS: With a follow up 
      of 5 years, the new-onset HFpEF occurred in 62 of 552 enrolled participants. 
      Among the different control level for diabetes, hypertension and AF, the 
      intensive blood glucose (BG) control, poor BP control and rate control of AF had 
      the highest risk of new-onset HFpEF, and the conservative BG control, intensive 
      BP control and rhythm control of AF had the lowest risk of new-onset HFpEF. 
      Multivariable Cox regression analysis showed that both poor BP control (hazard 
      ratio (HR): 1.421, 95% confidence interval (CI): 1.013-1.992, P = 0.042) and rate 
      control of AF (HR: 1.362, 95% CI: 1.006-1.821, P = 0.033) were independently 
      associated with the development of new-onset HFpEF. CONCLUSION: This study 
      demonstrated that, besides intensive BP control, conservative BG control and 
      rhythm control of AF were crucial factors to delay the progression of HFpEF among 
      patients with T2DM, hypertension and AF.
CI  - (c) 2020 Royal Australasian College of Physicians.
FAU - Fan, Li
AU  - Fan L
AD  - Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong 
      University School of Medicine, Shanghai, China.
FAU - Pan, Jian-An
AU  - Pan JA
AD  - Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong 
      University School of Medicine, Shanghai, China.
FAU - Lin, Hao
AU  - Lin H
AD  - Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong 
      University School of Medicine, Shanghai, China.
FAU - Wang, Chang-Qian
AU  - Wang CQ
AD  - Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong 
      University School of Medicine, Shanghai, China.
FAU - Zhang, Jun-Feng
AU  - Zhang JF
AD  - Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong 
      University School of Medicine, Shanghai, China.
FAU - Gu, Jun
AU  - Gu J
AUID- ORCID: 0000-0003-0999-864X
AD  - Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong 
      University School of Medicine, Shanghai, China.
LA  - eng
GR  - JYLJ201803/Clinical Research Program of 9th People's Hospital affiliated to 
      Shanghai Jiaotong University School of Medicine/
GR  - 81670293/National Nature Science Foundation of China/
GR  - 18411950500/Shanghai Science and Technology Commission/
GR  - 16CR2034B/Shanghai Shenkang Hospital Development Center/
GR  - YBKA201910/the project of construction and application of biobank for coronary 
      heart disease of Shanghai Ninth People's Hospital/
PT  - Journal Article
DEP - 20220112
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
RN  - 0 (Blood Glucose)
SB  - IM
MH  - *Atrial Fibrillation/diagnosis/epidemiology
MH  - Blood Glucose
MH  - Blood Pressure
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Heart Failure/diagnosis/epidemiology/prevention & control
MH  - Humans
MH  - Prognosis
MH  - Prospective Studies
MH  - Stroke Volume/physiology
OTO - NOTNLM
OT  - atrial fibrillation
OT  - diabetes mellitus
OT  - heart failure with preserved ejection fraction
OT  - hypertension
OT  - optimal management
EDAT- 2020/08/04 06:00
MHDA- 2022/03/18 06:00
CRDT- 2020/08/04 06:00
PHST- 2020/07/22 00:00 [revised]
PHST- 2020/03/14 00:00 [received]
PHST- 2020/07/29 00:00 [accepted]
PHST- 2020/08/04 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
PHST- 2020/08/04 06:00 [entrez]
AID - 10.1111/imj.15006 [doi]
PST - ppublish
SO  - Intern Med J. 2022 Feb;52(2):301-309. doi: 10.1111/imj.15006. Epub 2022 Jan 12.