PMID- 32746587 OWN - NLM STAT- MEDLINE DCOM- 20201029 LR - 20201029 IS - 1001-9391 (Print) IS - 1001-9391 (Linking) VI - 38 IP - 7 DP - 2020 Jul 20 TI - [The discussion of the correlation between tumor necrosis factor-alpha and aquaporin 4 expression in critical poisoning brain edema]. PG - 553-555 LID - 10.3760/cma.j.cn121094-20181211-00545 [doi] AB - Critical poisoning is a critical illness. Cerebral edema after poisoning is one of the important factors that cause the patient's condition to worsen and affect the prognosis of patients after acute brain injury. Aquaporin 4 (AQP-4) is an important member of the aquaporin family and is abundantly expressed in the central nervous system, playing a pivotal role in the formation of cerebral edema. Brain injury can cause the secretion of inflammatory transmitters, causing or aggravating cerebral edema. Tumor necrosis factor-alpha (TNF-alpha) has been confirmed to be most closely related to cerebral edema, and can participate in the formation and development of brain edema by regulating AQP-4. FAU - Cheng, Y L AU - Cheng YL AD - Department of Emergency Medicine of the Second Affiliated Hospital of Shandong First Medical University, Shandong Provincial Key Laboratory of Clinical Poisoning Research, Taian 271000, China. FAU - Liu, J AU - Liu J AD - Department of Emergency Medicine of the Second Affiliated Hospital of Shandong First Medical University, Shandong Provincial Key Laboratory of Clinical Poisoning Research, Taian 271000, China. FAU - Li, M AU - Li M AD - Intensive Care Unit of Beijing Wangfu Integrated Traditional Chinese and Western Medicine Hospital, Beijing 100049, China. LA - chi PT - Journal Article PL - China TA - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi JT - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases JID - 8410840 RN - 0 (Aquaporin 4) RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Animals MH - Aquaporin 4/*metabolism MH - Brain Edema/*metabolism MH - *Brain Injuries MH - Humans MH - Rats MH - Rats, Sprague-Dawley MH - Tumor Necrosis Factor-alpha/*metabolism OTO - NOTNLM OT - Aquaporin 4 OT - Brain edema OT - Critical poisoning OT - Tumor necrosis factor-alpha EDAT- 2020/08/05 06:00 MHDA- 2020/10/30 06:00 CRDT- 2020/08/05 06:00 PHST- 2020/08/05 06:00 [entrez] PHST- 2020/08/05 06:00 [pubmed] PHST- 2020/10/30 06:00 [medline] AID - 10.3760/cma.j.cn121094-20181211-00545 [doi] PST - ppublish SO - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2020 Jul 20;38(7):553-555. doi: 10.3760/cma.j.cn121094-20181211-00545.