PMID- 32747723
OWN - NLM
STAT- MEDLINE
DCOM- 20210826
LR  - 20220418
IS  - 1365-2540 (Electronic)
IS  - 0018-067X (Print)
IS  - 0018-067X (Linking)
VI  - 125
IP  - 5
DP  - 2020 Nov
TI  - Gamete-level immunogenetic incompatibility in humans-towards deeper understanding 
      of fertilization and infertility?
PG  - 281-289
LID - 10.1038/s41437-020-0350-8 [doi]
AB  - Human leukocyte antigen (HLA) immune genes play an important role in partner 
      selection, but it has remained unclear if nonrandom pairing with respect to 
      parental HLA genes could occur at the level of the gametes. We tested this 
      possibility by investigating whether the sperm fertilization competence in humans 
      is dependent on HLA genotype combination of the partners. We conducted a 
      full-factorial experiment, in which the sperm physiological preparation for 
      fertilization among multiple males was studied in the presence of follicular 
      fluid (oocyte surrounding bioactive liquid) of several females. All the studied 
      sperm pre-fertilization physiological parameters (motility, hyperactivation, 
      acrosome reaction, and viability) were strongly dependent on male-female 
      combination. In other words, follicular fluids (women) that induce strong sperm 
      physiological response in some males often induce much weaker response in the 
      other(s). Sperm physiological responses were stronger in HLA-dissimilar 
      male-female pairs than in HLA-similar combinations, but none of the measured 
      sperm traits were associated with genome-wide similarity. Together, these 
      findings shed new light on the evolutionary and immunological mechanisms of 
      fertilization. Furthermore, our results raise an intriguing possibility that 
      against currently prevailing WHO's definition, infertility may not represent 
      exclusively a pathological condition, but may also result from immunogenetic 
      incompatibility of the gametes.
FAU - Jokiniemi, Annalaura
AU  - Jokiniemi A
AUID- ORCID: 0000-0001-9566-8385
AD  - Department of Environmental and Biological Sciences, University of Eastern 
      Finland, P.O. Box 111, FI-80101, Joensuu, Finland.
FAU - Kuusipalo, Liisa
AU  - Kuusipalo L
AD  - North Karelia Central Hospital, Tikkamaentie 16, FI-80210, Joensuu, Finland.
FAU - Ritari, Jarmo
AU  - Ritari J
AUID- ORCID: 0000-0002-3458-9314
AD  - Research and Development, Finnish Red Cross Blood Service, Haartmaninkatu 8, 
      FI-00290, Helsinki, Finland.
FAU - Koskela, Satu
AU  - Koskela S
AD  - Research and Development, Finnish Red Cross Blood Service, Haartmaninkatu 8, 
      FI-00290, Helsinki, Finland.
FAU - Partanen, Jukka
AU  - Partanen J
AUID- ORCID: 0000-0001-6681-4734
AD  - Research and Development, Finnish Red Cross Blood Service, Haartmaninkatu 8, 
      FI-00290, Helsinki, Finland.
FAU - Kekalainen, Jukka
AU  - Kekalainen J
AUID- ORCID: 0000-0001-6303-6797
AD  - Department of Environmental and Biological Sciences, University of Eastern 
      Finland, P.O. Box 111, FI-80101, Joensuu, Finland. jukka.s.kekalainen@uef.fi.
LA  - eng
GR  - 308485 and 314105/Academy of Finland (Suomen Akatemia)/
GR  - 288393/Academy of Finland (Suomen Akatemia)/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200803
PL  - England
TA  - Heredity (Edinb)
JT  - Heredity
JID - 0373007
SB  - IM
MH  - Female
MH  - Fertilization/genetics
MH  - Germ Cells/*immunology
MH  - Humans
MH  - *Immunogenetics
MH  - *Infertility
MH  - Linear Models
MH  - Male
MH  - Models, Genetic
MH  - Spermatozoa/*immunology
PMC - PMC7553942
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/08/05 06:00
MHDA- 2021/08/27 06:00
PMCR- 2021/11/01
CRDT- 2020/08/05 06:00
PHST- 2019/12/21 00:00 [received]
PHST- 2020/07/23 00:00 [accepted]
PHST- 2020/07/22 00:00 [revised]
PHST- 2020/08/05 06:00 [pubmed]
PHST- 2021/08/27 06:00 [medline]
PHST- 2020/08/05 06:00 [entrez]
PHST- 2021/11/01 00:00 [pmc-release]
AID - 10.1038/s41437-020-0350-8 [pii]
AID - 350 [pii]
AID - 10.1038/s41437-020-0350-8 [doi]
PST - ppublish
SO  - Heredity (Edinb). 2020 Nov;125(5):281-289. doi: 10.1038/s41437-020-0350-8. Epub 
      2020 Aug 3.