PMID- 32748607
OWN - NLM
STAT- MEDLINE
DCOM- 20240221
LR  - 20240221
IS  - 2724-5780 (Electronic)
IS  - 2724-5780 (Linking)
VI  - 76
IP  - 1
DP  - 2024 Feb
TI  - Very high immunoglobulin E levels in children: when from pediatrician to 
      immunologist?
PG  - 13-18
LID - 10.23736/S2724-5276.20.05778-3 [doi]
AB  - BACKGROUND: Total serum immunoglobulin E (IgE) is increased in many situations 
      such as allergic diseases, primary immunodeficiencies (PID), parasitosis, 
      infections and malignancies. When IgE levels are >1000 kU/L PIDs are suspected by 
      pediatricians. We tried to define some clinical and laboratory parameters to 
      distinguish PID from the others. METHODS: We evaluated 158 children between 
      1.7-17 years (mean: 6.6+/-3.4) for allergic diseases, PID, parasitosis and others. 
      Total IgE, specific IgE, immunoglobulin levels and skin prick tests were 
      performed to all patients. Parasite investigations, viral serological tests and 
      detailed immunologic tests were analyzed in only patients who had suspected 
      complaints. Hyper IgE syndrome (HIES) scoring sheet was filled out for all 
      patients. RESULTS: Among all patients, 114 were diagnosed as bronchial asthma, 
      allergic rhino-conjunctivitis or atopic dermatitis. PID diagnosis was established 
      in totally 32 patients. Immunological evaluations were normal in 126 patients. 
      Eleven patients were accepted as parasitosis. Median HIES score was 18 (5-44 
      points). CONCLUSIONS: Pediatricians may use HIES scoring sheet when they suspect 
      a patient with PID. If the patient has very low points, they may follow the 
      patient. If there are about 18-20 points, they should get an opinion from an 
      immunologist for detailed immunologic tests.
FAU - Erol Cipe, Funda
AU  - Erol Cipe F
AD  - Department of Pediatric Allergy-Immunology, Kanuni Sultan Suleyman Research and 
      Training Hospital, Health Sciences University of Istanbul, Istanbul, Turkiye - 
      ferol76tr@hotmail.com.
FAU - Keskindemirci, Gonca
AU  - Keskindemirci G
AD  - Department of Pediatric Allergy-Immunology, Kanuni Sultan Suleyman Research and 
      Training Hospital, Health Sciences University of Istanbul, Istanbul, Turkiye.
AD  - Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkiye.
LA  - eng
PT  - Journal Article
DEP - 20200804
PL  - Italy
TA  - Minerva Pediatr (Torino)
JT  - Minerva pediatrics
JID - 101777303
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Humans
MH  - Immunoglobulin E
MH  - *Job Syndrome/diagnosis
MH  - Skin Tests
MH  - *Conjunctivitis, Allergic
MH  - Pediatricians
EDAT- 2020/08/05 06:00
MHDA- 2024/02/21 11:15
CRDT- 2020/08/05 06:00
PHST- 2024/02/21 11:15 [medline]
PHST- 2020/08/05 06:00 [pubmed]
PHST- 2020/08/05 06:00 [entrez]
AID - S0026-4946.20.05778-3 [pii]
AID - 10.23736/S2724-5276.20.05778-3 [doi]
PST - ppublish
SO  - Minerva Pediatr (Torino). 2024 Feb;76(1):13-18. doi: 
      10.23736/S2724-5276.20.05778-3. Epub 2020 Aug 4.