PMID- 32749544
OWN - NLM
STAT- MEDLINE
DCOM- 20211215
LR  - 20221207
IS  - 1860-1499 (Electronic)
IS  - 1860-1499 (Linking)
VI  - 54
IP  - 2
DP  - 2021 Jun
TI  - Epithelial-myoepithelial carcinoma ex-pleomorphic adenoma of the parotid gland: 
      report of a rare case with immunohistochemical and genetic analyses.
PG  - 173-180
LID - 10.1007/s00795-020-00262-6 [doi]
AB  - Epithelial-myoepithelial carcinoma (EMCa) is a rare low-grade salivary 
      malignancy. It is rare for EMCa to occur as the carcinomatous component of 
      carcinoma ex-pleomorphic adenoma (PA). We examined one additional case of EMCa 
      ex-PA, immunohistochemically and genetically. The patient was an 83-year-old 
      female, who suffered from swelling of the right parotid region. Histologically, 
      the tumor contained a hyalinized nodule, which displayed elastosis. The main 
      tumor exhibited a bi-layered structure, involving inner ductal cells and clear 
      outer myoepithelial cells. Immunostaining indicated that the inner cells were 
      positive for epithelial membrane antigen, whereas the outer cells were positive 
      for p40. On the genetic level, the carcinoma harbored no HRAS gene mutations, 
      whereas fluorescence in situ hybridization (FISH) of the Pleomorphic Adenoma 
      Gene1 showed splitting signals in the carcinomatous component. We diagnosed this 
      case as EMCa ex-PA. It is necessary to differentiate EMCa ex-PA from 
      myoepithelial carcinoma and clear cell carcinoma, and FISH is useful for such 
      purposes.
FAU - Kusafuka, Kimihide
AU  - Kusafuka K
AUID- ORCID: 0000-0001-5315-2540
AD  - Department of Pathology, Shizuoka General Hospital, 4-27-1 Kita-ando, Aoi-ku, 
      Shizuoka, 420-8527, Japan. k-kusafuka@i.shizuoka-pho.jp.
FAU - Yamashita, Masaru
AU  - Yamashita M
AD  - Department of Head and Neck Surgery and Otorhinolaryngology, Shizuoka General 
      Hospital, Shizuoka, Japan.
FAU - Muramatsu, Aya
AU  - Muramatsu A
AD  - Department of Pathology, Shizuoka General Hospital, 4-27-1 Kita-ando, Aoi-ku, 
      Shizuoka, 420-8527, Japan.
FAU - Arai, Kazumori
AU  - Arai K
AD  - Department of Pathology, Shizuoka General Hospital, 4-27-1 Kita-ando, Aoi-ku, 
      Shizuoka, 420-8527, Japan.
FAU - Suzuki, Makoto
AU  - Suzuki M
AD  - Department of Pathology, Shizuoka General Hospital, 4-27-1 Kita-ando, Aoi-ku, 
      Shizuoka, 420-8527, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20200804
PL  - Japan
TA  - Med Mol Morphol
JT  - Medical molecular morphology
JID - 101239023
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (PLAG1 protein, human)
RN  - EC 3.6.5.2 (HRAS protein, human)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
SB  - IM
MH  - Adenoma, Pleomorphic/*diagnosis/genetics/pathology
MH  - Aged, 80 and over
MH  - Asian People
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Mutation
MH  - Parotid Neoplasms/*diagnosis/genetics/pathology
MH  - Proto-Oncogene Proteins p21(ras)
OTO - NOTNLM
OT  - Carcinoma ex-pleomorphic adenoma
OT  - Epithelial-myoepithelial carcinoma
OT  - FISH
OT  - HRAS gene
OT  - Pleomorphic adenoma gene 1 gene
EDAT- 2020/08/05 06:00
MHDA- 2021/12/16 06:00
CRDT- 2020/08/05 06:00
PHST- 2020/06/11 00:00 [received]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/08/05 06:00 [pubmed]
PHST- 2021/12/16 06:00 [medline]
PHST- 2020/08/05 06:00 [entrez]
AID - 10.1007/s00795-020-00262-6 [pii]
AID - 10.1007/s00795-020-00262-6 [doi]
PST - ppublish
SO  - Med Mol Morphol. 2021 Jun;54(2):173-180. doi: 10.1007/s00795-020-00262-6. Epub 
      2020 Aug 4.