PMID- 32749680
OWN - NLM
STAT- MEDLINE
DCOM- 20210907
LR  - 20211204
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 236
IP  - 2
DP  - 2021 Feb
TI  - Light-emitting diode irradiation induces AKT/mTOR-mediated apoptosis in human 
      pancreatic cancer cells and xenograft mouse model.
PG  - 1362-1374
LID - 10.1002/jcp.29943 [doi]
AB  - The beneficial effects of light-emitting diode (LED) irradiation have been 
      reported in various pathologies, including cancer. However, its effect in 
      pancreatic cancer cells remains unclear. Herein, we demonstrated that blue LED of 
      460 nm regulated pancreatic cancer cell proliferation and apoptosis by 
      suppressing the expression of apoptosis-related factors, such as mutant p53 and 
      B-cell lymphoma 2 (Bcl-2), and decreasing the expression of RAC-beta 
      serine/threonine kinase 2 (AKT2), the phosphorylation of protein kinase B (AKT), 
      and mammalian target of rapamycin (mTOR). Blue LED irradiation also increased the 
      levels of cleaved poly-(ADP-ribose) polymerase (PARP) and caspase-3 in pancreatic 
      cancer cells, while it suppressed AKT2 expression and inhibited tumor growth in 
      xenograft tumor tissues. In conclusion, blue LED irradiation suppressed 
      pancreatic cancer cell and tumor growth by regulating AKT/mTOR signaling. Our 
      findings indicated that blue LEDs could be used as a nonpharmacological treatment 
      for pancreatic cancer.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Kim, Young Mi
AU  - Kim YM
AUID- ORCID: 0000-0002-1475-5434
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital, Yangsan, Republic of Korea.
FAU - Ko, Sung-Hwa
AU  - Ko SH
AUID- ORCID: 0000-0003-4900-5972
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital, Yangsan, Republic of Korea.
AD  - Department of Rehabilitation Medicine, Pusan National University Yangsan 
      Hospital, Yangsan, Republic of Korea.
FAU - Shin, Yong-Il
AU  - Shin YI
AUID- ORCID: 0000-0001-7894-0930
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital, Yangsan, Republic of Korea.
AD  - Department of Rehabilitation Medicine, School of Medicine, Pusan National 
      University, Yangsan, Republic of Korea.
FAU - Kim, Yeonye
AU  - Kim Y
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital, Yangsan, Republic of Korea.
FAU - Kim, Taehyung
AU  - Kim T
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital, Yangsan, Republic of Korea.
FAU - Jung, Jaehoon
AU  - Jung J
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital, Yangsan, Republic of Korea.
FAU - Lee, Sang-Yull
AU  - Lee SY
AD  - Department of Biochemistry, School of Medicine, Pusan National University, 
      Yangsan, Republic of Korea.
FAU - Kim, Nam Gyun
AU  - Kim NG
AD  - Medical Research Center of Color Seven, Seoul, Republic of Korea.
FAU - Park, Kyoung-Jun
AU  - Park KJ
AD  - Medical Research Center of Color Seven, Seoul, Republic of Korea.
FAU - Ryu, Ji Hyeon
AU  - Ryu JH
AUID- ORCID: 0000-0003-0342-3108
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital, Yangsan, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200804
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (AKT1 protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Apoptosis/*genetics/radiation effects
MH  - Cell Line, Tumor
MH  - Cell Proliferation/*genetics/radiation effects
MH  - Gene Expression Regulation, Neoplastic/genetics/radiation effects
MH  - Humans
MH  - Light
MH  - Mice
MH  - Pancreatic Neoplasms/genetics/pathology/*radiotherapy
MH  - Phosphatidylinositol 3-Kinases/genetics
MH  - Phosphorylation/radiation effects
MH  - Proto-Oncogene Proteins c-akt/*genetics
MH  - TOR Serine-Threonine Kinases/*genetics
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - AKT/mTOR pathway
OT  - LED irradiation
OT  - apoptosis
OT  - pancreatic cancer
OT  - tumor growth
EDAT- 2020/08/05 06:00
MHDA- 2021/09/08 06:00
CRDT- 2020/08/05 06:00
PHST- 2020/01/24 00:00 [received]
PHST- 2020/06/24 00:00 [revised]
PHST- 2020/07/02 00:00 [accepted]
PHST- 2020/08/05 06:00 [pubmed]
PHST- 2021/09/08 06:00 [medline]
PHST- 2020/08/05 06:00 [entrez]
AID - 10.1002/jcp.29943 [doi]
PST - ppublish
SO  - J Cell Physiol. 2021 Feb;236(2):1362-1374. doi: 10.1002/jcp.29943. Epub 2020 Aug 
      4.