PMID- 32750551
OWN - NLM
STAT- MEDLINE
DCOM- 20201211
LR  - 20211102
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 190
DP  - 2020 Nov
TI  - The joint effect of ambient air pollution and agricultural pesticide exposures on 
      lung function among children with asthma.
PG  - 109903
LID - S0013-9351(20)30798-2 [pii]
LID - 10.1016/j.envres.2020.109903 [doi]
AB  - BACKGROUND: Ambient environmental pollutants have been shown to adversely affect 
      respiratory health in susceptible populations. However, the role of simultaneous 
      exposure to multiple diverse environmental pollutants is poorly understood. 
      OBJECTIVE: We applied a multidomain, multipollutant approach to assess the 
      association between pediatric lung function measures and selected ambient air 
      pollutants and pesticides. METHODS: Using data from the US EPA and California 
      Pesticide Use Registry, we reconstructed three months prior exposure to ambient 
      air pollutants ((ozone (O(3)), nitrogen dioxide (NO(2)), particulate matter with 
      a median aerodynamic diameter < 2.5 mum (PM(2.5)) and <10 mum (PM(10))) and 
      pesticides (organophosphates (OP), carbamates (C) and methyl bromide (MeBr)) for 
      153 children with mild intermittent or mild persistent asthma from the San 
      Joaquin Valley of California, USA. We implemented Bayesian kernel machine 
      regression (BKMR) to estimate the association between simultaneous exposures to 
      air pollutants and pesticides and lung function measures (forced expiratory 
      volume in 1 s (FEV(1)), forced vital capacity (FVC), and forced expiratory flow 
      between 25% and 75% of vital capacity (FEF(25-75))). RESULTS: In BKMR analysis, 
      the overall effect of mixtures (pollutants and pesticides) was associated with 
      reduced FEV(1) and FVC, particularly when all the environmental exposures were 
      above their 60th percentile. For example, the effect of the overall mixture at 
      the 70th percentile (compared to the median) was a -0.12SD (-50 mL, 95% CI: 
      -180 mL, 90 mL) change in the FEV(1) and a -0.18SD (-90 mL, 95% CI: -240 mL, 
      60 mL) change in the FVC. However, 95% credible intervals around all of the joint 
      effect estimates contained the null value. CONCLUSION: At this agricultural-urban 
      interface, we observed results from multipollutant analyses, suggestive of 
      adverse effects on some pediatric lung function measures following a cumulative 
      increase in ambient air pollutants and agricultural pesticides. Given the 
      uncertainty in effect estimates, this approach should be explored in larger 
      studies.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Benka-Coker, Wande
AU  - Benka-Coker W
AD  - Department of Environmental and Radiological Health Sciences, Colorado State 
      University, Fort Collins, CO, USA. Electronic address: 
      wande.benka-coker@colostate.edu.
FAU - Hoskovec, Lauren
AU  - Hoskovec L
AD  - Department of Statistics, Colorado State University, Fort Collins, CO, USA.
FAU - Severson, Rachel
AU  - Severson R
AD  - Colorado Department of Public Health and Environment; Denver, Colorado, USA.
FAU - Balmes, John
AU  - Balmes J
AD  - Division of Environmental Health Sciences, School of Public Health, University of 
      California, Berkeley, CA, USA.
FAU - Wilson, Ander
AU  - Wilson A
AD  - Department of Statistics, Colorado State University, Fort Collins, CO, USA.
FAU - Magzamen, Sheryl
AU  - Magzamen S
AD  - Department of Environmental and Radiological Health Sciences, Colorado State 
      University, Fort Collins, CO, USA.
LA  - eng
GR  - K22 ES023815/ES/NIEHS NIH HHS/United States
GR  - R01 ES028811/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20200718
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - 0 (Pesticides)
RN  - 66H7ZZK23N (Ozone)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - *Air Pollutants/analysis/toxicity
MH  - *Air Pollution/adverse effects/analysis
MH  - *Asthma/chemically induced/epidemiology
MH  - Bayes Theorem
MH  - Child
MH  - Environmental Exposure/adverse effects/analysis
MH  - Humans
MH  - Lung
MH  - Nitrogen Dioxide/analysis
MH  - *Ozone/analysis
MH  - Particulate Matter/analysis
MH  - *Pesticides/toxicity
PMC - PMC7529969
MID - NIHMS1614686
OTO - NOTNLM
OT  - Air pollution
OT  - Complex mixtures
OT  - Lung function
OT  - Pediatric asthma
OT  - Pesticides
COIS- Declaration of interests The authors declare that they have no known competing 
      financial interests or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2020/08/05 06:00
MHDA- 2020/12/15 06:00
PMCR- 2021/11/01
CRDT- 2020/08/05 06:00
PHST- 2020/02/10 00:00 [received]
PHST- 2020/06/21 00:00 [revised]
PHST- 2020/06/30 00:00 [accepted]
PHST- 2020/08/05 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/08/05 06:00 [entrez]
PHST- 2021/11/01 00:00 [pmc-release]
AID - S0013-9351(20)30798-2 [pii]
AID - 10.1016/j.envres.2020.109903 [doi]
PST - ppublish
SO  - Environ Res. 2020 Nov;190:109903. doi: 10.1016/j.envres.2020.109903. Epub 2020 
      Jul 18.