PMID- 32751867
OWN - NLM
STAT- MEDLINE
DCOM- 20210311
LR  - 20231104
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 8
DP  - 2020 Jul 31
TI  - Attenuating Effect of Peruvian Cocoa Populations on the Acute Asthmatic Response 
      in Brown Norway Rats.
LID - 10.3390/nu12082301 [doi]
LID - 2301
AB  - Cocoa contains bioactive components, which vary according to genetic and 
      environmental factors. The present study aimed to ascertain the anti-allergic 
      properties of native Peruvian cocoa populations ("Blanco de Piura" or BPC, 
      "Amazonas Peru" or APC, "Criollo de Montana" or CMC, "Chuncho" or CCC, and an 
      ordinary cocoa or OC). To do so, after an initial in vitro approach, an in vivo 
      study focused on the induction of an anaphylactic response associated with 
      allergic asthma in Brown Norway rats was carried out. Based on their polyphenol 
      content, antioxidant activity and in vitro effects, the APC and CMC were selected 
      to be included in the in vivo study. Cocoa diets were tested in a model of 
      allergic asthma in which anaphylactic response was assessed by changes in body 
      temperature, motor activity and body weight. The concentration of specific 
      immunoglobulin E (IgE), mast cell protease and leukotrienes was also quantified 
      in serum and/or bronchoalveolar lavage fluid. CMC and OC populations exhibited a 
      protective effect on the allergic asthma rat model as evidenced by means of a 
      partial protection against anaphylactic response and, above all, in the synthesis 
      of IgE and the release of mast cell protease.
FAU - Periz, Marta
AU  - Periz M
AD  - Seccio de Fisiologia, Departament de Bioquimica i Fisiologia, Facultat de 
      Farmacia i Ciencies de l'Alimentacio, Universitat de Barcelona (UB), 08028 
      Barcelona, Spain.
AD  - Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), UB, 08921 
      Santa Coloma de Gramenet, Spain.
FAU - Perez-Cano, Francisco J
AU  - Perez-Cano FJ
AUID- ORCID: 0000-0001-6243-9164
AD  - Seccio de Fisiologia, Departament de Bioquimica i Fisiologia, Facultat de 
      Farmacia i Ciencies de l'Alimentacio, Universitat de Barcelona (UB), 08028 
      Barcelona, Spain.
AD  - Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), UB, 08921 
      Santa Coloma de Gramenet, Spain.
FAU - Cambras, Trinitat
AU  - Cambras T
AUID- ORCID: 0000-0002-9009-4690
AD  - Seccio de Fisiologia, Departament de Bioquimica i Fisiologia, Facultat de 
      Farmacia i Ciencies de l'Alimentacio, Universitat de Barcelona (UB), 08028 
      Barcelona, Spain.
FAU - Franch, Angels
AU  - Franch A
AUID- ORCID: 0000-0002-2362-1374
AD  - Seccio de Fisiologia, Departament de Bioquimica i Fisiologia, Facultat de 
      Farmacia i Ciencies de l'Alimentacio, Universitat de Barcelona (UB), 08028 
      Barcelona, Spain.
AD  - Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), UB, 08921 
      Santa Coloma de Gramenet, Spain.
FAU - Best, Ivan
AU  - Best I
AUID- ORCID: 0000-0001-6009-6575
AD  - Programa Cacao, Ingenieria Agroforestal, Facultad de Ciencias Ambientales, 
      Universidad Cientifica del Sur, Lima 15842, Peru.
AD  - Unidad de Investigacion en Nutricion, Salud, Alimentos Funcionales y 
      Nutraceuticos, Universidad San Ignacio de Loyola, Lima 15024, Peru.
FAU - Pastor-Soplin, Santiago
AU  - Pastor-Soplin S
AUID- ORCID: 0000-0001-7109-417X
AD  - Programa Cacao, Ingenieria Agroforestal, Facultad de Ciencias Ambientales, 
      Universidad Cientifica del Sur, Lima 15842, Peru.
FAU - Castell, Margarida
AU  - Castell M
AUID- ORCID: 0000-0001-5408-0593
AD  - Seccio de Fisiologia, Departament de Bioquimica i Fisiologia, Facultat de 
      Farmacia i Ciencies de l'Alimentacio, Universitat de Barcelona (UB), 08028 
      Barcelona, Spain.
AD  - Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), UB, 08921 
      Santa Coloma de Gramenet, Spain.
FAU - Massot-Cladera, Malen
AU  - Massot-Cladera M
AUID- ORCID: 0000-0002-5220-2793
AD  - Seccio de Fisiologia, Departament de Bioquimica i Fisiologia, Facultat de 
      Farmacia i Ciencies de l'Alimentacio, Universitat de Barcelona (UB), 08028 
      Barcelona, Spain.
AD  - Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), UB, 08921 
      Santa Coloma de Gramenet, Spain.
LA  - eng
GR  - 137-2017-FONDECYT/Fondo Nacional de Desarrollo Cientifico, Tecnologico y de 
      Innovacion Tecnologica/
PT  - Journal Article
DEP - 20200731
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Antioxidants)
RN  - 0 (Leukotrienes)
RN  - 0 (Polyphenols)
RN  - 0 (Protective Agents)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.- (Peptide Hydrolases)
SB  - IM
MH  - Anaphylaxis/chemically induced/prevention & control
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Asthma/chemically induced/*prevention & control
MH  - Body Temperature/drug effects
MH  - Body Weight/drug effects
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Cacao/*chemistry
MH  - Diet/methods
MH  - Disease Models, Animal
MH  - Hypersensitivity/prevention & control
MH  - Immunoglobulin E/analysis
MH  - Leukotrienes/analysis
MH  - Motor Activity/drug effects
MH  - Peptide Hydrolases/analysis
MH  - Peru
MH  - Polyphenols/*pharmacology
MH  - Protective Agents/*pharmacology
MH  - Rats
PMC - PMC7469048
OTO - NOTNLM
OT  - IgE
OT  - Theobroma cacao
OT  - anaphylaxis
OT  - asthma
OT  - leukotriene
OT  - mast cell protease
OT  - methylxanthines
OT  - motor activity
OT  - polyphenols
OT  - temperature
COIS- The authors declare no conflict of interest.
EDAT- 2020/08/06 06:00
MHDA- 2021/03/12 06:00
PMCR- 2020/08/01
CRDT- 2020/08/06 06:00
PHST- 2020/06/15 00:00 [received]
PHST- 2020/07/17 00:00 [revised]
PHST- 2020/07/24 00:00 [accepted]
PHST- 2020/08/06 06:00 [entrez]
PHST- 2020/08/06 06:00 [pubmed]
PHST- 2021/03/12 06:00 [medline]
PHST- 2020/08/01 00:00 [pmc-release]
AID - nu12082301 [pii]
AID - nutrients-12-02301 [pii]
AID - 10.3390/nu12082301 [doi]
PST - epublish
SO  - Nutrients. 2020 Jul 31;12(8):2301. doi: 10.3390/nu12082301.