PMID- 32754221
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 1735-5303 (Print)
IS  - 2345-3656 (Electronic)
IS  - 1735-5303 (Linking)
VI  - 15
IP  - 3
DP  - 2020 Summer
TI  - Cyclin D1 Expression in Patients with Laryngeal Squamous Cell Carcinoma.
PG  - 245-250
LID - 10.30699/ijp.2020.116579.2276 [doi]
AB  - BACKGROUND & OBJECTIVE: Laryngeal squamous cell carcinoma (LSCC) is considered to 
      be one of the most common cancers of the head and neck, accounting for roughly 
      90% of all malignant tumors of the larynx. To have a timely diagnosis for a 
      better and practical therapy, molecular markers have to be investigated. The aim 
      of this study was to determine the expression of Cyclin D1 (CD1) in patients with 
      laryngeal squamous cell carcinoma. METHODS: In this study the demographic data of 
      82 patients with laryngeal squamous cell carcinoma, including age, gender and 
      geographical region history of smoking and drug abuse, paraclinical findings, 
      surgical description, and pathologic reports were extracted from their medical 
      records. The stage and grade of the disease and tumor location were determined 
      using their medical records. An appropriate tissue sample was selected. Then, the 
      selected cancerous tissue samples stored as formalin-fixed paraffin-embedded 
      tissue then were (Immunohistochemistry) IHC stained and analyzed in terms of the 
      expression of CD1. RESULTS & CONCLUSION: According to the results, 75 out of 82 
      (91.5%) investigated samples were positive for CD1 expression. There was a 
      significant relationship between stage of the disease (P=0.041) and CD1 
      expression in patients with laryngeal squamous cell carcinoma. There was no 
      significant relationship between gender (P=0.055), age (P=0.256), history of 
      smoking and drug abuse (P=0.192), location of the tumor (P=0.90), grade of the 
      disease (P=0.515) and geographical region (P=0.466) and CD1 expression in 
      patients with laryngeal squamous cell carcinoma. The results of the present study 
      showed that CD1 expression was higher (91.5%) in patients with laryngeal squamous 
      cell carcinoma in comparison to the other studies. According to the results we 
      can conclude that stage of the disease can significantly affect CD1 expression in 
      patients with squamous cell carcinoma.
FAU - Zand, Vahid
AU  - Zand V
AD  - Dept. of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research 
      Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
FAU - Binesh, Fariba
AU  - Binesh F
AD  - Dept. of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
FAU - Meybodian, Mojtaba
AU  - Meybodian M
AD  - Dept. of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research 
      Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
FAU - Safi Dahaj, Farzan
AU  - Safi Dahaj F
AD  - Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, 
      Iran.
FAU - Alamdar Yazdi, Arezoo
AU  - Alamdar Yazdi A
AD  - Dept. of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research 
      Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
LA  - eng
PT  - Journal Article
DEP - 20200501
PL  - Iran
TA  - Iran J Pathol
JT  - Iranian journal of pathology
JID - 101515128
PMC - PMC7354075
OTO - NOTNLM
OT  - Cyclin D1
OT  - Gene expression
OT  - Immunohistochemistry
OT  - Type D Cyclins
EDAT- 2020/08/06 06:00
MHDA- 2020/08/06 06:01
PMCR- 2020/06/01
CRDT- 2020/08/06 06:00
PHST- 2019/11/28 00:00 [received]
PHST- 2020/04/14 00:00 [accepted]
PHST- 2020/08/06 06:00 [entrez]
PHST- 2020/08/06 06:00 [pubmed]
PHST- 2020/08/06 06:01 [medline]
PHST- 2020/06/01 00:00 [pmc-release]
AID - 10.30699/ijp.2020.116579.2276 [doi]
PST - ppublish
SO  - Iran J Pathol. 2020 Summer;15(3):245-250. doi: 10.30699/ijp.2020.116579.2276. 
      Epub 2020 May 1.