PMID- 32755416
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 1615-7109 (Electronic)
IS  - 1203-4754 (Linking)
VI  - 24
IP  - 6
DP  - 2020 Nov/Dec
TI  - Uncommon Adverse Effects of Deoxycholic Acid Injection for Submental Fullness: 
      Beyond the Clinical Trials.
PG  - 619-624
LID - 10.1177/1203475420943270 [doi]
AB  - Deoxycholic acid (BELKYRA(TM), Allergan, Markham, ON, Canada) is a minimally 
      invasive injectable treatment approved by Health Canada for the nonsurgical 
      reduction of submental fullness. Multiple phase III clinical trials have proven 
      the efficacy and safety of deoxycholic acid. In the clinical trials, the most 
      common adverse events (AEs) reported, such as injection site pain, numbness, 
      swelling, bruising and induration, were transient and mild-to-moderate in 
      severity. Additional postmarketing AEs have been reported in the literature. In 
      this study, we reviewed the uncommon reported events and aimed to increase 
      clinician awareness of the potential adverse effects for patient counselling of 
      risks and benefits, identify AEs of procedures that may be performed outside of 
      the medical environment, and identify factors that increase the risk of an 
      adverse event. Beyond the clinical trials, real-world case reports and case 
      series have been reported for the AEs of alopecia, transient neuropraxia, 
      vascular occlusive events/vascular injury, and skin necrosis. Dermatologists need 
      to be aware of these risks, for the treatment and management of their own 
      patients and for those patients who may be treated outside the medical clinic 
      environment that present for medical management of these AEs.
FAU - Metzger, Kristy C
AU  - Metzger KC
AUID- ORCID: 0000-0002-7974-7312
AD  - SKiN Centre for Dermatology, Peterborough, ON, Canada.
AD  - 6515 Trent University, Peterborough, ON, Canada.
FAU - Crowley, Erika L
AU  - Crowley EL
AD  - SKiN Centre for Dermatology, Peterborough, ON, Canada.
AD  - 6515 Trent University, Peterborough, ON, Canada.
FAU - Kadlubowska, Dorota
AU  - Kadlubowska D
AD  - SKiN Centre for Dermatology, Peterborough, ON, Canada.
AD  - Probity Medical Research, Waterloo, ON, Canada.
FAU - Gooderham, Melinda J
AU  - Gooderham MJ
AUID- ORCID: 0000-0001-8926-0113
AD  - SKiN Centre for Dermatology, Peterborough, ON, Canada.
AD  - Probity Medical Research, Waterloo, ON, Canada.
AD  - Queen's University, Kingston, ON, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200805
PL  - United States
TA  - J Cutan Med Surg
JT  - Journal of cutaneous medicine and surgery
JID - 9614685
RN  - 0 (Dermatologic Agents)
RN  - 005990WHZZ (Deoxycholic Acid)
SB  - IM
MH  - Chin
MH  - Cosmetic Techniques/*adverse effects
MH  - Deoxycholic Acid/administration & dosage/*adverse effects
MH  - Dermatologic Agents/administration & dosage/*adverse effects
MH  - Humans
MH  - Injection Site Reaction/etiology
MH  - Injections, Subcutaneous
MH  - Lipectomy/adverse effects/methods
MH  - Subcutaneous Fat/drug effects
OTO - NOTNLM
OT  - ATX-101
OT  - Belkyra
OT  - Kybella
OT  - adverse effects
OT  - deoxycholic acid
OT  - submental fullness
EDAT- 2020/08/07 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/08/07 06:00
PHST- 2020/08/07 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/08/07 06:00 [entrez]
AID - 10.1177/1203475420943270 [doi]
PST - ppublish
SO  - J Cutan Med Surg. 2020 Nov/Dec;24(6):619-624. doi: 10.1177/1203475420943270. Epub 
      2020 Aug 5.