PMID- 3275562
OWN - NLM
STAT- MEDLINE
DCOM- 19880225
LR  - 20190516
IS  - 0892-6638 (Print)
IS  - 0892-6638 (Linking)
VI  - 2
IP  - 1
DP  - 1988 Jan
TI  - How antibodies work: focus on Fc receptors.
PG  - 3-11
AB  - It is increasingly appreciated that the part of an antibody not involved in the 
      binding of antigen--the Fc region--plays an important biological role. It 
      activates a variety of receptors not only on so-called effector cells such as 
      macrophages and granulocytes, but also on lymphocytes, and it can thereby 
      modulate the immune response itself. Over the past 2 years much new information 
      has been gained about the structure of such receptors, in large part through 
      molecular genetics. In this review we describe the structure and some aspects of 
      the function of the most complicated of the cellular Fc receptors so far 
      identified: the receptor with high affinity for immunoglobulin E (IgE) on mast 
      cells. The structure of its IgE-binding chain is strikingly similar to the 
      corresponding polypeptide of an immunoglobulin G receptor. Like the latter and 
      like a receptor that binds polymeric immunoglobulin, segments of the protein 
      resemble immunoglobulin sequences. It is surprising that other IgE-binding 
      proteins that putatively serve related functions have completely different 
      structures.
FAU - Metzger, H
AU  - Metzger H
AD  - National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, 
      Maryland 20892.
FAU - Kinet, J P
AU  - Kinet JP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Antibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Fc)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies/*immunology
MH  - Humans
MH  - *Hypersensitivity
MH  - Immunoglobulin E/immunology
MH  - Immunoglobulin G/immunology
MH  - Receptors, Fc/*immunology
RF  - 40
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1096/fasebj.2.1.3275562 [doi]
PST - ppublish
SO  - FASEB J. 1988 Jan;2(1):3-11. doi: 10.1096/fasebj.2.1.3275562.