PMID- 32757065
OWN - NLM
STAT- MEDLINE
DCOM- 20210701
LR  - 20211204
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Print)
IS  - 1439-6319 (Linking)
VI  - 120
IP  - 10
DP  - 2020 Oct
TI  - Effect of carbohydrate-protein supplementation on endurance training adaptations.
PG  - 2273-2287
LID - 10.1007/s00421-020-04450-1 [doi]
AB  - PURPOSE: To examine the influence of post-exercise protein feeding upon the 
      adaptive response to endurance exercise training. METHODS: In a randomised 
      parallel group design, 25 healthy men and women completed 6 weeks of endurance 
      exercise training by running on a treadmill for 30-60 min at 70-75% maximal 
      oxygen uptake (VO(2max)) 4 times/week. Participants ingested 1.6 g per kilogram 
      of body mass (g kg BM(-1)) of carbohydrate (CHO) or an isocaloric 
      carbohydrate-protein solution (CHO-P; 0.8 g carbohydrate kg BM(-1) + 0.8 g 
      protein kg BM(-1)) immediately and 1 h post-exercise. Expired gas, blood and 
      muscle biopsy samples were taken at baseline and follow-up. RESULTS: Exercise 
      training improved VO(2max) in both groups (p </= 0.001), but this increment was not 
      different between groups either in absolute terms or relative to body mass 
      (0.2 +/- 0.2 L min(-1) and 3.0 +/- 2 mL kg(-1) min(-1), respectively). No change 
      occurred in plasma albumin concentration from baseline to follow-up with CHO-P 
      (4.18 +/- 0.18 to 4.23 +/- 0.17 g dL(-1)) or CHO (4.17 +/- 0.17 to 
      4.12 +/- 0.22 g dL(-1); interaction: p > 0.05). Mechanistic target of rapamycin 
      (mTOR) gene expression was up-regulated in CHO-P (+ 46%; p = 0.025) relative to 
      CHO (+ 4%) following exercise training. CONCLUSION: Post-exercise protein 
      supplementation up-regulated the expression of mTOR in skeletal muscle over 
      6 weeks of endurance exercise training. However, the magnitude of improvement in 
      VO(2max) was similar between groups.
FAU - Alghannam, Abdullah F
AU  - Alghannam AF
AUID- ORCID: 0000-0002-6118-7337
AD  - Lifestyle and Health Research Center, Health Sciences Research Center, Princess 
      Nourah Bint Abdulrahman University, Riyadh, 84428, Saudi Arabia. 
      AFAlghannam@pnu.edu.sa.
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK. 
      AFAlghannam@pnu.edu.sa.
FAU - Templeman, Iain
AU  - Templeman I
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
FAU - Thomas, Joel E
AU  - Thomas JE
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
FAU - Jedrzejewski, Dawid
AU  - Jedrzejewski D
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
FAU - Griffiths, Samuel
AU  - Griffiths S
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
FAU - Lemon, Joseph
AU  - Lemon J
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
FAU - Byers, Thomas
AU  - Byers T
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
FAU - Reeves, Sue
AU  - Reeves S
AD  - Department of Life Sciences, University of Roehampton, London, SW15 4JD, UK.
FAU - Gonzalez, Javier T
AU  - Gonzalez JT
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
FAU - Thompson, Dylan
AU  - Thompson D
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
FAU - Bilzon, James
AU  - Bilzon J
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
FAU - Tsintzas, Kostas
AU  - Tsintzas K
AD  - School of Life Sciences, University of Nottingham, Queen's Medical Centre, 
      Nottingham, NG7 2UH, UK.
FAU - Betts, James A
AU  - Betts JA
AD  - Department for Health, University of Bath, Bath, BA2 7AY, UK.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200805
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adaptation, Physiological/*drug effects
MH  - Adolescent
MH  - Adult
MH  - Dietary Carbohydrates/administration & dosage/*pharmacology
MH  - Dietary Proteins/administration & dosage/*pharmacology
MH  - Endurance Training/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/metabolism/physiology
MH  - Oxygen Consumption
MH  - TOR Serine-Threonine Kinases/genetics/metabolism
PMC - PMC7502056
OTO - NOTNLM
OT  - Amino acids
OT  - Post-exercise nutrition
OT  - Recovery
OT  - Running
OT  - Sucrose
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/08/07 06:00
MHDA- 2021/07/02 06:00
PMCR- 2020/08/05
CRDT- 2020/08/07 06:00
PHST- 2019/12/08 00:00 [received]
PHST- 2020/07/30 00:00 [accepted]
PHST- 2020/08/07 06:00 [pubmed]
PHST- 2021/07/02 06:00 [medline]
PHST- 2020/08/07 06:00 [entrez]
PHST- 2020/08/05 00:00 [pmc-release]
AID - 10.1007/s00421-020-04450-1 [pii]
AID - 4450 [pii]
AID - 10.1007/s00421-020-04450-1 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2020 Oct;120(10):2273-2287. doi: 10.1007/s00421-020-04450-1. 
      Epub 2020 Aug 5.