PMID- 32757373
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211101
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 26
IP  - 3
DP  - 2021 May
TI  - Neural correlates of cue-induced changes in decision-making distinguish subjects 
      with gambling disorder from healthy controls.
PG  - e12951
LID - 10.1111/adb.12951 [doi]
AB  - In addiction, there are few human studies on the neural basis of cue-induced 
      changes in value-based decision making (Pavlovian-to-instrumental transfer, PIT). 
      It is especially unclear whether neural alterations related to PIT are due to the 
      physiological effects of substance abuse or rather related to learning processes 
      and/or other etiological factors related to addiction. We have thus investigated 
      whether neural activation patterns during a PIT task help to distinguish subjects 
      with gambling disorder (GD), a nonsubstance-based addiction, from healthy 
      controls (HCs). Thirty GD and 30 HC subjects completed an affective 
      decision-making task in a functional magnetic resonance imaging (fMRI) scanner. 
      Gambling-associated and other emotional cues were shown in the background during 
      the task. Data collection and feature modeling focused on a network of nucleus 
      accumbens (NAcc), amygdala, and orbitofrontal cortex (OFC) (derived from PIT and 
      substance use disorder [SUD] studies). We built and tested a linear classifier 
      based on these multivariate neural PIT signatures. GD subjects showed stronger 
      PIT than HC subjects. Classification based on neural PIT signatures yielded a 
      significant area under the receiver operating curve (AUC-ROC) (0.70, p = 0.013). 
      GD subjects showed stronger PIT-related functional connectivity between NAcc and 
      amygdala elicited by gambling cues, as well as between amygdala and OFC elicited 
      by negative and positive cues. HC and GD subjects were thus distinguishable by 
      PIT-related neural signatures including amygdala-NAcc-OFC functional 
      connectivity. Neural PIT alterations in addictive disorders might not depend on 
      the physiological effect of a substance of abuse but on related learning 
      processes or even innate neural traits.
CI  - (c) 2020 The Authors. Addiction Biology published by John Wiley & Sons Ltd on 
      behalf of Society for the Study of Addiction.
FAU - Genauck, Alexander
AU  - Genauck A
AUID- ORCID: 0000-0002-9159-0709
AD  - Department of Psychiatry and Psychotherapy, Charite-Universitatsmedizin Berlin, 
      Berlin, Germany.
AD  - Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.
FAU - Matthis, Caroline
AU  - Matthis C
AD  - Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.
AD  - Institute of Software Engineering and Theoretical Computer Science, Neural 
      Information Processing, Technische Universitat Berlin, Berlin, Germany.
FAU - Andrejevic, Milan
AU  - Andrejevic M
AD  - Melbourne School of Psychological Sciences, The University of Melbourne, 
      Melbourne, Victoria, Australia.
FAU - Ballon, Lukas
AU  - Ballon L
AD  - Department of Psychiatry and Psychotherapy, Charite-Universitatsmedizin Berlin, 
      Berlin, Germany.
FAU - Chiarello, Francesca
AU  - Chiarello F
AD  - Psychiatry Unit, Department of Health Sciences, University of Florence, Florence, 
      Italy.
FAU - Duecker, Katharina
AU  - Duecker K
AD  - Department of Psychology, Carl-von-Ossietzky Universitat Oldenburg, Oldenburg, 
      Germany.
FAU - Heinz, Andreas
AU  - Heinz A
AD  - Department of Psychiatry and Psychotherapy, Charite-Universitatsmedizin Berlin, 
      Berlin, Germany.
FAU - Kathmann, Norbert
AU  - Kathmann N
AD  - Department of Psychology, Humboldt-Universitat zu Berlin, Berlin, Germany.
FAU - Romanczuk-Seiferth, Nina
AU  - Romanczuk-Seiferth N
AD  - Department of Psychiatry and Psychotherapy, Charite-Universitatsmedizin Berlin, 
      Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200805
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
SB  - IM
MH  - Adult
MH  - Behavior, Addictive/*psychology
MH  - Brain/*physiopathology
MH  - Case-Control Studies
MH  - Cues
MH  - *Decision Making
MH  - Female
MH  - Gambling/*psychology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
OTO - NOTNLM
OT  - Pavlovian-to-instrumental transfer
OT  - decision making
OT  - fMRI
OT  - gambling disorder
EDAT- 2020/08/07 06:00
MHDA- 2021/11/03 06:00
CRDT- 2020/08/07 06:00
PHST- 2020/07/05 00:00 [revised]
PHST- 2019/11/06 00:00 [received]
PHST- 2020/07/20 00:00 [accepted]
PHST- 2020/08/07 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2020/08/07 06:00 [entrez]
AID - 10.1111/adb.12951 [doi]
PST - ppublish
SO  - Addict Biol. 2021 May;26(3):e12951. doi: 10.1111/adb.12951. Epub 2020 Aug 5.