PMID- 3275751
OWN - NLM
STAT- MEDLINE
DCOM- 19880223
LR  - 20170210
IS  - 0732-183X (Print)
IS  - 0732-183X (Linking)
VI  - 6
IP  - 1
DP  - 1988 Jan
TI  - Histopathology of childhood sarcomas, Intergroup Rhabdomyosarcoma Studies I and 
      II: clinicopathologic correlation.
PG  - 67-75
AB  - Histopathologic material from 1,782 patients registered in the Intergroup 
      Rhabdomyosarcoma Study Committee (IRS)-I and -II were reviewed by the IRS 
      Pathology Committee in order to provide a uniform approach to classification and 
      correlate patient survival with tumor type. Categories considered eligible were 
      the four types of rhabdomyosarcoma (RMS) (criteria of Horn and Enterline), 
      extraosseous Ewing's tumor (EOE), and a group of somewhat variable 
      undifferentiated sarcomas designated small round cell sarcoma, type indeterminate 
      (STI). Tumors that were clearly sarcomas but were unclassifiable also were 
      included (NOS). The committee diagnoses were embryonal (Emb) RMS in 877 (54%), 
      alveolar (Alv) RMS in 343 (21%), botryoid (Botr) RMS in 88 (5%), pleomorphic 
      (Pleo) RMS in 11 (1%), STI in 135 (8%), and EOE in 84 (5%). One in nine were 
      mixtures of types, eg, Emb and Alv. Five percent of the sarcomas could not be 
      classified because of inadequate material. In general, there was close agreement 
      (94%) between the review committee and institutional pathologists in the 
      diagnosis of RMS, but not in the specific types, particularly Alv RMS (41%) and 
      STI (36%). This observation is important, since patients with Alv RMS and STI 
      tumors had decreased survival compared with the other histologies. The prognosis 
      varied by histology, with Botr having the best, Alv RMS and STI the worst, and 
      Emb RMS and EOE an intermediate prognosis.
FAU - Newton, W A Jr
AU  - Newton WA Jr
AD  - Department of Laboratory Medicine, Children's Hospital, Columbus, OH 43205.
FAU - Soule, E H
AU  - Soule EH
FAU - Hamoudi, A B
AU  - Hamoudi AB
FAU - Reiman, H M
AU  - Reiman HM
FAU - Shimada, H
AU  - Shimada H
FAU - Beltangady, M
AU  - Beltangady M
FAU - Maurer, H
AU  - Maurer H
LA  - eng
GR  - CA-24507/CA/NCI NIH HHS/United States
GR  - CA-29139/CA/NCI NIH HHS/United States
GR  - CA-30138/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of 
      Clinical Oncology
JID - 8309333
SB  - IM
MH  - Age Factors
MH  - Child
MH  - Clinical Trials as Topic
MH  - Extremities
MH  - Female
MH  - Head and Neck Neoplasms/pathology
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Rhabdomyosarcoma/mortality/*pathology
MH  - Sarcoma/mortality/pathology
MH  - Sarcoma, Ewing/mortality/pathology
MH  - Urogenital Neoplasms/pathology
EDAT- 1988/01/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1200/JCO.1988.6.1.67 [doi]
PST - ppublish
SO  - J Clin Oncol. 1988 Jan;6(1):67-75. doi: 10.1200/JCO.1988.6.1.67.