PMID- 32757989
OWN - NLM
STAT- MEDLINE
DCOM- 20210430
LR  - 20221207
IS  - 0975-4466 (Electronic)
IS  - 0256-4947 (Print)
IS  - 0256-4947 (Linking)
VI  - 40
IP  - 4
DP  - 2020 Jul-Aug
TI  - Associations between human leukocyte antigen C locus polymorphism and psoriatic 
      arthritis in populations of European and Middle Eastern descent: a meta-analysis.
PG  - 338-346
LID - 10.5144/0256-4947.2020.338 [doi]
AB  - BACKGROUND: Gene-disease association between human leukocyte antigen (HLA)-C 
      locus polymorphism and psoriatic arthritis (PsA) remains controversial. 
      OBJECTIVE: Evaluate the relationship between HLA-C locus polymorphism and PsA in 
      populations of European and Middle Eastern descent. SEARCH METHODS: PubMed, PMC, 
      Elsevier and Google Scholar databases from 1980 to January 2020. The search was 
      limited to articles in English. SELECTION CRITERIA: Case-control studies (with 
      unrelated participants) that had allele/genotype data on the association between 
      HLA-C locus polymorphism and PsA susceptibility. DATA COLLECTION AND ANALYSIS: 
      Two investigators searched independently in searching the literature. 
      Disagreements were resolved by discussion and consultation with a third 
      researcher. The Q-Genie tool was used to assess the quality of articles. RESULTS: 
      Twenty-five studies met the inclusion criteria. At the allelic level, three 
      alleles were associated with an increased risk of PsA and five were associated 
      with a reduced risk. At the phenotypic level, four alleles were associated with 
      increased risk of PsA and three were associated with a reduced risk. At both the 
      allelic and phenotypic levels, the results revealed that HLA-C*04 played a 
      protective role in PsA (The pooled odds ratio [OR] is 0.66 for allelic level and 
      0.63 for phenotypic level), while HLA-C*02, *06 and *12 increased the risk of 
      suffering from PsA (The pooled ORs of C*02, *06 and *12 are 2.21, 2.63 and 1.49 
      for allelic level, and 1.79, 2.96 and 2.25 for phenotypic level, respectively). 
      CONCLUSION: The pooled results showed a significant association between PsA and 
      the HLA-C gene in populations of European and Middle Eastern descent. At both the 
      allelic and phenotypic levels, the HLA-C*02, *06 and *12 may contribute to 
      susceptibility to PsA, while HLA-C*04 may confer a protective role against PsA. 
      REGISTRATION: Not registered. CONFLICT OF INTEREST: None.
FAU - Shao, Lin-Nan
AU  - Shao LN
AD  - From the Blood Group, Balian Blood Center, Dalian, China.
FAU - Wang, Ni
AU  - Wang N
AD  - From the Blood Group, Balian Blood Center, Dalian, China.
FAU - Zhou, Shi-Hang
AU  - Zhou SH
AD  - From the Blood Group, Balian Blood Center, Dalian, China.
FAU - Wang, Zi
AU  - Wang Z
AD  - From the Department of Sports Medicine, Dalian Municipal Central Hospital, 
      Dalian, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200806
PL  - Saudi Arabia
TA  - Ann Saudi Med
JT  - Annals of Saudi medicine
JID - 8507355
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Alleles
MH  - Arthritis, Psoriatic/ethnology/*genetics
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Europe/ethnology
MH  - Female
MH  - Genetic Loci/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Middle East/ethnology
MH  - Odds Ratio
MH  - Polymorphism, Genetic/*genetics
MH  - White People/*genetics
PMC - PMC7410226
EDAT- 2020/08/08 06:00
MHDA- 2021/05/01 06:00
PMCR- 2020/07/01
CRDT- 2020/08/08 06:00
PHST- 2020/08/08 06:00 [entrez]
PHST- 2020/08/08 06:00 [pubmed]
PHST- 2021/05/01 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 0256-4947.2020.338 [pii]
AID - 10.5144/0256-4947.2020.338 [doi]
PST - ppublish
SO  - Ann Saudi Med. 2020 Jul-Aug;40(4):338-346. doi: 10.5144/0256-4947.2020.338. Epub 
      2020 Aug 6.