PMID- 32758551 OWN - NLM STAT- MEDLINE DCOM- 20210111 LR - 20210111 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 191 DP - 2020 Dec TI - Increased risk of occupational trichloroethylene hypersensitivity syndrome at exposure levels higher than 15 mg/L of urinary trichloroacetic acid, regardless of whether the patients had the HLA-B*13:01 allele. PG - 109972 LID - S0013-9351(20)30867-7 [pii] LID - 10.1016/j.envres.2020.109972 [doi] AB - Occupational trichloroethylene (TCE) exposure can cause hypersensitivity syndrome (TCE-HS). The human leukocyte antigen (HLA)-B*13:01 is reportedly an important allele involved in TCE-HS onset. However, the threshold exposure level causing TCE-HS in relation to HLA-B*13:01 remains unknown. We conducted a case-control study comprising 37 TCE-HS patients and 97 age- and sex-matched TCE-tolerant controls from the Han Chinese population. Urine and blood of patients were collected on the first day of hospitalization, and those of controls were collected at the end of their shifts. Urinary trichloroacetic acid (TCA) was measured as an exposure marker, and end-of-shift levels in the patients were estimated using the biological half-life of 83.7 h. HLA-B genotype was identified using DNA from blood. Crude odds ratios (ORs) for TCE-HS in the groups with urinary TCA concentration >15 mg/L to 50 mg/L were 21.9 [95% confidence interval (CI) 4.2-114.1] and 27.6 (6.1-125.8), respectively, when the group with urinary TCA 15 to 50 mg/L, and for HLA-B*13:01 were 33.4 (4.1-270.8), 34.0 (5.3-217.1), and 11.0 (2.4-50.7), respectively. In conclusion, reduction of TCE exposure to 15 mg/L showed increased risk of TCE-HS, regardless of whether the patients had the HLA-B*13:01 allele. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Wang, Hailan AU - Wang H AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: 896725998@qq.com. FAU - Nakajima, Tamie AU - Nakajima T AD - Department of Life and Health Sciences, Chubu University, 487-8501, Kasugai, Japan. Electronic address: tnasu23@med.nagoya-u.ac.jp. FAU - Ito, Yuki AU - Ito Y AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, 467-8601, Nagoya, Japan. Electronic address: yukey@med.nagoya-cu.ac.jp. FAU - Naito, Hisao AU - Naito H AD - Department of Public Health, Fujita Health University School of Medicine, 470-1192, Toyoake, Japan. Electronic address: naitoh@med.nagoya-u.ac.jp. FAU - Zhao, Na AU - Zhao N AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: zhaonabmu@126.com. FAU - Li, Hongling AU - Li H AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: honglinglee5@126.com. FAU - Qiu, Xinxiang AU - Qiu X AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: zfyqxx@163.com. FAU - Xia, Lihua AU - Xia L AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: xialh@163.com. FAU - Chen, Jiabin AU - Chen J AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: cjb6666@126.com. FAU - Wu, Qifeng AU - Wu Q AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: rigewu@126.com. FAU - Li, Laiyu AU - Li L AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: 13662533086@139.com. FAU - Huang, Hanlin AU - Huang H AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: huanghl@gdoh.org. FAU - Yanagiba, Yukie AU - Yanagiba Y AD - National Institute of Occupational Safety and Health, 214-8585, Kawasaki, Japan. Electronic address: yanagiba@h.jniosh.go.jp. FAU - Qu, Hongyung AU - Qu H AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, 510300, Guangzhou, PR China. Electronic address: hzlaoying@163.com. FAU - Yatsuya, Hiroshi AU - Yatsuya H AD - Department of Public Health, Fujita Health University School of Medicine, 470-1192, Toyoake, Japan. Electronic address: yatsuya@fujita-hu.ac.jp. FAU - Kamijima, Michihiro AU - Kamijima M AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, 467-8601, Nagoya, Japan. Electronic address: kamijima@med.nagoya-cu.ac.jp. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200803 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (HLA-B Antigens) RN - 290YE8AR51 (Trichloroethylene) RN - 5V2JDO056X (Trichloroacetic Acid) SB - IM MH - Alleles MH - Case-Control Studies MH - HLA-B Antigens/genetics MH - Humans MH - *Occupational Exposure/adverse effects MH - Trichloroacetic Acid MH - *Trichloroethylene/analysis/toxicity OTO - NOTNLM OT - Case-control study OT - Han Chinese OT - Human biomonitoring OT - Odds ratio OT - Risk assessment EDAT- 2020/08/08 06:00 MHDA- 2021/01/12 06:00 CRDT- 2020/08/08 06:00 PHST- 2020/03/26 00:00 [received] PHST- 2020/06/18 00:00 [revised] PHST- 2020/07/17 00:00 [accepted] PHST- 2020/08/08 06:00 [pubmed] PHST- 2021/01/12 06:00 [medline] PHST- 2020/08/08 06:00 [entrez] AID - S0013-9351(20)30867-7 [pii] AID - 10.1016/j.envres.2020.109972 [doi] PST - ppublish SO - Environ Res. 2020 Dec;191:109972. doi: 10.1016/j.envres.2020.109972. Epub 2020 Aug 3.