PMID- 32759178
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 2332-7812 (Electronic)
IS  - 2332-7812 (Linking)
VI  - 7
IP  - 5
DP  - 2020 Sep
TI  - Validation of the NEOS score in Chinese patients with anti-NMDAR encephalitis.
LID - 10.1212/NXI.0000000000000860 [doi]
LID - e860
AB  - OBJECTIVE: The performance of anti-NMDAR Encephalitis One-Year Functional Status 
      (NEOS) in predicting the 1-year functional status in Chinese patients with 
      anti-NMDAR encephalitis is unknown. METHODS: We recruited patients with 
      anti-NMDAR encephalitis from the Multicenter and Prospective Clinical Registry 
      Study of Anti-NMDAR Encephalitis in Beijing Area. Patients were followed up for 1 
      year. We defined the poor functional status as a modified Rankin Scale score of 
      more than 2 and good functional status as a modified Rankin Scale score of no 
      more than 2. We performed a receiver-operator characteristic analysis to assess 
      the discriminatory power of the NEOS score in predicting the 1-year functional 
      status by using the area under the curve (AUC). Calibration was assessed by 
      Pearson correlation coefficient and Hosmer-Lemeshow tests. RESULTS: Among the 111 
      patients with anti-NMDAR encephalitis recruited from 364 potentially eligible 
      participants, 87 (78.4%) had good functional status at 1 year, whereas the 
      remaining 24 (21.6%) had poor functional status. The AUC of the NEOS score for 
      1-year poor functional status was 0.86 (95% CI 0.78-0.93, p < 0.001). The 
      increased NEOS was associated with higher risk of 1-year poor functional status 
      in patients with anti-NMDAR encephalitis. CONCLUSIONS: The NEOS score is 
      considered a reliable predictor of the risk of 1-year poor functional status in 
      Chinese patients with anti-NMDAR encephalitis. This score could help to estimate 
      the velocity of clinical improvement in advance. CLINICALTRIALGOV IDENTIFIER: 
      NCT02443350. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence 
      that in patients with anti-NMDAR encephalitis, the NEOS score predicts 1-year 
      functional status.
CI  - Copyright (c) 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American Academy of Neurology.
FAU - Peng, Yujing
AU  - Peng Y
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Dai, Feifei
AU  - Dai F
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Liu, Lei
AU  - Liu L
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Chen, Weiqi
AU  - Chen W
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Yan, Hongyi
AU  - Yan H
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Liu, Aihua
AU  - Liu A
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Zhang, Xinghu
AU  - Zhang X
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Wang, Xiaohui
AU  - Wang X
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China. wangjwcq@163.com.
FAU - He, Junying
AU  - He J
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Li, Yatong
AU  - Li Y
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Li, Chenxi
AU  - Li C
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Chen, Liuxi
AU  - Chen L
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Li, Lin
AU  - Li L
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Ma, Qiuying
AU  - Ma Q
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China.
FAU - Wang, Jiawei
AU  - Wang J
AD  - From the Department of Neurology, Beijing Tong Ren Hospital, Capital Medical 
      University (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); 
      Medical Research Center, Beijing Tong Ren Hospital, Capital Medical University 
      (Y.P., F.D., L. Liu, Y.L., C.L., L.C., Y.Z., L. Li, Q.M., J.W.); Department of 
      Neurology, Beijing Tiantan Hospital, Capital Medical University (W.C., H.Y., 
      X.Z.); Department of Neurology, Xuanwu Hospital, Capital Medical University 
      (A.L.), Beijing; Beijing Children Hospital, Capital Medical University (X.W.); 
      Department of Neurology, the Second Hospital of Hebei Medical University (J.H.), 
      Shijiazhuang; China National Clinical Research Center for Neurological Diseases 
      (W.C., H.Y.), Beijing; Center of Stroke, Beijing Institute for Brain Disorders 
      (W.C., H.Y.); and Beijing Key Laboratory of Translational Medicine for 
      Cerebrovascular Disease (W.C., H.Y.), China. wangjwcq@163.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT02443350
PT  - Clinical Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20200805
PL  - United States
TA  - Neurol Neuroimmunol Neuroinflamm
JT  - Neurology(R) neuroimmunology & neuroinflammation
JID - 101636388
SB  - IM
MH  - Adult
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*diagnosis/therapy
MH  - China
MH  - Female
MH  - Follow-Up Studies
MH  - *Functional Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Statistical
MH  - Outcome Assessment, Health Care/*standards
MH  - Prognosis
MH  - *Registries
MH  - Reproducibility of Results
MH  - *Severity of Illness Index
PMC - PMC7413709
EDAT- 2020/08/08 06:00
MHDA- 2021/09/14 06:00
PMCR- 2020/08/05
CRDT- 2020/08/08 06:00
PHST- 2020/03/30 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/08/08 06:00 [entrez]
PHST- 2020/08/08 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2020/08/05 00:00 [pmc-release]
AID - 7/5/e860 [pii]
AID - NEURIMMINFL2020028936 [pii]
AID - 10.1212/NXI.0000000000000860 [doi]
PST - epublish
SO  - Neurol Neuroimmunol Neuroinflamm. 2020 Aug 5;7(5):e860. doi: 
      10.1212/NXI.0000000000000860. Print 2020 Sep.