PMID- 32760710
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 8
DP  - 2020
TI  - Soft Matrix Combined With BMPR Inhibition Regulates Neurogenic Differentiation of 
      Human Umbilical Cord Mesenchymal Stem Cells.
PG  - 791
LID - 10.3389/fbioe.2020.00791 [doi]
LID - 791
AB  - Stem cells constantly encounter as well as respond to a variety of signals in 
      their microenvironment. Although the role of biochemical factors has always been 
      emphasized, the significance of biophysical signals has not been studied until 
      recently. Additionally, biophysical elements, like extracellular matrix (ECM) 
      stiffness, can regulate functions of stem cells. In this study, we demonstrated 
      that soft matrix with 1-10 kPa can induce neural differentiation of human 
      umbilical cord mesenchymal stem cells (hUC-MSCs). Importantly, we used a 
      combination of soft matrix and bone morphogenetic protein receptor (BMPR) 
      inhibition to promote neurogenic differentiation of hUC-MSCs. Furthermore, 
      BMPR/SMADs occurs in crosstalk with the integrinbeta1 downstream signaling pathway. 
      In addition, BMPR inhibition plays a positive role in maintaining the 
      undifferentiated state of hUC-MSCs on the hydrogel substrate. The results provide 
      further evidence for the molecular mechanisms via which stem cells convert 
      mechanical inputs into fateful decisions.
CI  - Copyright (c) 2020 Sun, Xu, Wang, Lv, Wu, Chi, Li and Li.
FAU - Sun, Yingying
AU  - Sun Y
AD  - The Key Laboratory of Pathobiology, Ministry of Education, College of Basic 
      Medical Sciences, Jilin University, Changchun, China.
AD  - Department of Stomatology, First Hospital of Jilin University, Changchun, China.
FAU - Xu, Ziran
AU  - Xu Z
AD  - The Key Laboratory of Pathobiology, Ministry of Education, College of Basic 
      Medical Sciences, Jilin University, Changchun, China.
FAU - Wang, Meijing
AU  - Wang M
AD  - The Key Laboratory of Pathobiology, Ministry of Education, College of Basic 
      Medical Sciences, Jilin University, Changchun, China.
FAU - Lv, Shuang
AU  - Lv S
AD  - The Key Laboratory of Pathobiology, Ministry of Education, College of Basic 
      Medical Sciences, Jilin University, Changchun, China.
FAU - Wu, Haitao
AU  - Wu H
AD  - The Key Laboratory of Pathobiology, Ministry of Education, College of Basic 
      Medical Sciences, Jilin University, Changchun, China.
FAU - Chi, Guangfan
AU  - Chi G
AD  - The Key Laboratory of Pathobiology, Ministry of Education, College of Basic 
      Medical Sciences, Jilin University, Changchun, China.
FAU - Li, Lisha
AU  - Li L
AD  - The Key Laboratory of Pathobiology, Ministry of Education, College of Basic 
      Medical Sciences, Jilin University, Changchun, China.
FAU - Li, Yulin
AU  - Li Y
AD  - The Key Laboratory of Pathobiology, Ministry of Education, College of Basic 
      Medical Sciences, Jilin University, Changchun, China.
LA  - eng
PT  - Journal Article
DEP - 20200714
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC7372119
OTO - NOTNLM
OT  - bone morphogenetic protein receptor
OT  - hydrogel
OT  - mesenchymal stem cells
OT  - neural differentiation
OT  - stiffness
EDAT- 2020/08/08 06:00
MHDA- 2020/08/08 06:01
PMCR- 2020/01/01
CRDT- 2020/08/08 06:00
PHST- 2020/04/29 00:00 [received]
PHST- 2020/06/22 00:00 [accepted]
PHST- 2020/08/08 06:00 [entrez]
PHST- 2020/08/08 06:00 [pubmed]
PHST- 2020/08/08 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fbioe.2020.00791 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2020 Jul 14;8:791. doi: 10.3389/fbioe.2020.00791. 
      eCollection 2020.