PMID- 32760782
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2363-4715 (Electronic)
IS  - 2363-4707 (Print)
IS  - 2363-4715 (Linking)
VI  - 7
IP  - 1
DP  - 2020
TI  - Reactive mesothelial hyperplasia mimicking mesothelioma in an African green 
      monkey (Chlorocebus aethiops).
PG  - 5-12
LID - 10.5194/pb-7-5-2020 [doi]
AB  - A spontaneous reactive mesothelial hyperplasia occurred in a female, 
      15.7-year-old African green monkey (grivet; Chlorocebus aethiops). At necropsy, 
      massive effusions were found in the abdomen, the thorax, and the pericardium. 
      Additionally, multiple small, beige-gray nodules were detected on the serosal 
      surfaces of the abdominal organs. Histopathologically, the mesothelial cells 
      resembled the epithelioid subtype of a mesothelioma, but no infiltrative or 
      invasive growth could be demonstrated. The mesothelial cells on the thoracis, 
      liver, and intestinal serosa were accompanied by chronic serositis. Mesothelial 
      cells expressed cytokeratin, vimentin, calretinin, desmin, Wilms Tumor 1 (WT-1) 
      protein, and epithelial membrane antigen (EMA). Cells were negative for 
      carcinoembryonic antigen (CEA), cluster of differentiation 15 (CD15), and 
      podoplanin. Ultrastructurally, cells revealed a moderate amount of microvilli of 
      medium length, perinuclear tonofilament bundles, and long desmosomes. In 
      fluorescence in situ hybridization (FISH) for the detection of characteristic 
      gene loss (p16; CDKN2A), NF2, and MTAP, no deletions were detected. No asbestos 
      fibers and no presence of Simian virus 40 antigen (SV40) could be demonstrated.
CI  - Copyright: (c) 2020 Roland Plesker et al.
FAU - Plesker, Roland
AU  - Plesker R
AD  - Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany.
FAU - Kohler, Kernt
AU  - Kohler K
AD  - Institut fur Veterinar-Pathologie, Justus-Liebig-Universitat Giessen, Giessen, 
      Germany.
FAU - von Gerlach, Susanne
AU  - von Gerlach S
AD  - UGP MVZ, Institut fur Pathologie, Zytologie und Molekularpathologie GbR, 
      Wettenberg, Germany.
FAU - Boller, Klaus
AU  - Boller K
AD  - Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany.
FAU - Vogt, Markus
AU  - Vogt M
AD  - Institut fur Pathologie, Ruhr-Universitat Bochum, Bochum, Germany.
FAU - Feder, Inke S
AU  - Feder IS
AD  - Institut fur Pathologie, Ruhr-Universitat Bochum, Bochum, Germany.
LA  - eng
PT  - Journal Article
DEP - 20200615
PL  - Germany
TA  - Primate Biol
JT  - Primate biology
JID - 101730502
PMC - PMC7399384
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/08/08 06:00
MHDA- 2020/08/08 06:01
PMCR- 2020/06/15
CRDT- 2020/08/08 06:00
PHST- 2020/02/26 00:00 [received]
PHST- 2020/05/12 00:00 [accepted]
PHST- 2020/08/08 06:00 [entrez]
PHST- 2020/08/08 06:00 [pubmed]
PHST- 2020/08/08 06:01 [medline]
PHST- 2020/06/15 00:00 [pmc-release]
AID - 01021829 [pii]
AID - 10.5194/pb-7-5-2020 [doi]
PST - epublish
SO  - Primate Biol. 2020 Jun 15;7(1):5-12. doi: 10.5194/pb-7-5-2020. eCollection 2020.