PMID- 32761372
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20211021
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 77
IP  - 4
DP  - 2021 Apr
TI  - ImpaCt of aspirin regimen on THrombin generation in diabEtic patients with acute 
      coronary syndrome: CARTHaGE-ACS trial.
PG  - 517-526
LID - 10.1007/s00228-020-02969-y [doi]
AB  - BACKGROUND: Diabetes is associated with a high rate of events after acute 
      coronary syndrome. It was recently reported that once-daily aspirin might not 
      provide stable biological efficacy in patients with diabetes. AIMS: We sought to 
      compare the biological efficacy of aspirin given once a day versus aspirin 
      divided twice per day in a population of diabetic patients with non-ST elevation 
      acute coronary syndrome (NSTE-ACS) as assessed by the thrombin generation test. 
      METHODS: We performed an open-label single-blind randomized study including 59 
      consecutive diabetic patients admitted for NSTE-ACS. Patients were randomly 
      treated with aspirin 100 mg once a day (GA100; n = 20), aspirin 160 mg once a day 
      (GA160; n = 19) or aspirin 100 mg twice a day (G2A100; n = 20). The primary 
      endpoint was endogenous thrombin potential (ETP) at discharge and after 6 months. 
      RESULTS: The mean age of our patients was 61.5 +/- 9 years, and 73% were male. The 
      baseline characteristics were comparable between the three groups. In the GA100 
      group, there was no significant effect on ETP variation at 6 months 
      (1150.46 +/- 504.84 vs. 1087.63 +/- 454.18; p = 0.794). An increase in aspirin dose 
      with a second daily administration of 100 mg was associated with a significant 
      reduction in ETP at 6 months (1004.87 +/- 196.2 vs. 1233.63 +/- 333.5; p = 0.003). A 
      nonsignificant decrease in ETP was seen in the GA160 group (from 1173.8 +/- 388.07 
      to 1053.64 +/- 269.93 at 6 months, p = 0.117). CONCLUSION: Only the twice-daily 
      aspirin regimen led to better control of hypercoagulability in NSTE-ACS diabetic 
      patients. However, no thrombin generation normalization was reported.
FAU - Boussofara, Amine
AU  - Boussofara A
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
FAU - Laroussi, Lobna
AU  - Laroussi L
AUID- ORCID: 0000-0002-1593-9593
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia. 
      lobna_laroussi@hotmail.com.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia. 
      lobna_laroussi@hotmail.com.
AD  - , Residence Diar Ons apartment B 2 1, Riadh El Andalos, 2058, Ariana, Tunisia. 
      lobna_laroussi@hotmail.com.
FAU - Baccouche, Hela
AU  - Baccouche H
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
AD  - Department of Hematology, Rabta Hospital, Tunis, Tunisia.
FAU - Bennour, Emna
AU  - Bennour E
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
FAU - Kasbaoui, Sami
AU  - Kasbaoui S
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
FAU - Triki, Hbib
AU  - Triki H
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
FAU - Zied, Ibn El Haj
AU  - Zied EH
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
AD  - Taher Maamouri Hospital, Nabeul, Tunisia.
FAU - Kammoun, Ikram
AU  - Kammoun I
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
FAU - Halima, Afef Ben
AU  - Halima AB
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
FAU - Addad, Faouzi
AU  - Addad F
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
FAU - Marrakchi, Sonia
AU  - Marrakchi S
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
FAU - Romdhane, Neila Ben
AU  - Romdhane NB
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
AD  - Department of Hematology, Rabta Hospital, Tunis, Tunisia.
FAU - Kachboura, Salem
AU  - Kachboura S
AD  - Department of Cardiology, Abderrahmen Mami Hospital, Tunis, Tunisia.
AD  - Faculty of Medicine of Tunis- Tunis University El Manar, Tunis, Tunisia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200806
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - EC 3.4.21.5 (Thrombin)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Acute Coronary Syndrome/blood/*drug therapy
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aspirin/*administration & dosage/adverse effects
MH  - Diabetes Mellitus/blood/*drug therapy
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Platelet Aggregation Inhibitors/*administration & dosage/adverse effects
MH  - Single-Blind Method
MH  - Thrombin/metabolism
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Aspirin
OT  - Diabetes
OT  - Thrombin generation
EDAT- 2020/08/08 06:00
MHDA- 2023/02/25 06:00
CRDT- 2020/08/08 06:00
PHST- 2019/11/25 00:00 [received]
PHST- 2020/07/20 00:00 [accepted]
PHST- 2020/08/08 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2020/08/08 06:00 [entrez]
AID - 10.1007/s00228-020-02969-y [pii]
AID - 10.1007/s00228-020-02969-y [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2021 Apr;77(4):517-526. doi: 10.1007/s00228-020-02969-y. 
      Epub 2020 Aug 6.