PMID- 32761978
OWN - NLM
STAT- MEDLINE
DCOM- 20210929
LR  - 20210929
IS  - 1932-7005 (Electronic)
IS  - 1932-6254 (Linking)
VI  - 14
IP  - 10
DP  - 2020 Oct
TI  - Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel 
      for skin wound dressing applications.
PG  - 1488-1501
LID - 10.1002/term.3115 [doi]
AB  - It is a challenging task to develop active biomacromolecular wound dressing 
      materials that are biocompatible and possesses antibacterial properties against 
      the bacterial strains that cause severe skin disease. This work is focused on the 
      preparation of a biocompatible and degradable hydrogel for wound dressing 
      application using arabinoxylan (ARX) and guar gum (GG) natural polymers. Fourier 
      transform infrared spectroscopy (FT-IR) confirmed that both ARX and GG interacted 
      well with each other, and their interactions further increased with the addition 
      of crosslinker tetraethyl orthosilicate. Scanning electron microscope (SEM) 
      micrographs showed uniform porous morphologies of the hydrogels. The porous 
      morphologies and uniform interconnected pores are attributed to the increased 
      crosslinking of the hydrogel. Elastic modulus, tensile strength, and fracture 
      strain of the hydrogels significantly improved (from ATG-1 to ATG-4) with 
      crosslinking. Degradability tests showed that hydrogels lost maximum weight in 7 
      days. All the samples showed variation in swelling with pH. Maximum swelling was 
      observed at pH 7. The hydrogel samples showed good antibacterial activity against 
      Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Gram-positive) 
      in PBS, good drug release profile (92% drug release), and nontoxic cellular 
      behavior. The cells not only retained their cylindrical morphologies onto the 
      hydrogel but were also performing their normal activities. It is, therefore, 
      believed that as-developed hydrogel could be a potential material for wound 
      dressing application.
CI  - (c) 2020 John Wiley & Sons, Ltd.
FAU - Khan, Muhammad Umar Aslam
AU  - Khan MUA
AD  - Department of Polymer Engineering and Technology, University of the Punjab, 
      Lahore, Pakistan.
AD  - Department of Metallurgy and Materials Engineering, CEET, University of the 
      Punjab, Lahore, Pakistan.
AD  - School of Biomedical Engineering and Health Sciences, Faculty of Engineering, 
      Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.
FAU - Raza, Mohsin Ali
AU  - Raza MA
AD  - Department of Metallurgy and Materials Engineering, CEET, University of the 
      Punjab, Lahore, Pakistan.
FAU - Razak, Saiful Izwan Abd
AU  - Razak SIA
AD  - School of Biomedical Engineering and Health Sciences, Faculty of Engineering, 
      Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.
AD  - Centre for Advanced Composite Materials, Universiti Teknologi Malaysia, Skudai, 
      Johor, Malaysia.
FAU - Abdul Kadir, Mohammed Rafiq
AU  - Abdul Kadir MR
AD  - School of Biomedical Engineering and Health Sciences, Faculty of Engineering, 
      Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.
FAU - Haider, Adnan
AU  - Haider A
AD  - Department of Biological Sciences, National University of Medical Sciences, 
      Rawalpindi, Punjab, Pakistan.
FAU - Shah, Saqlain A
AU  - Shah SA
AD  - Nanotechnology and Biomaterials Lab, Physics Department, Forman Christian College 
      University, Lahore, Pakistan.
FAU - Mohd Yusof, Abdul Halim
AU  - Mohd Yusof AH
AD  - School of Chemical and Energy Engineering, Faculty of Engineering, Universiti 
      Teknologi Malaysia, Skudai, Johor, Malaysia.
FAU - Haider, Sajjad
AU  - Haider S
AUID- ORCID: 0000-0002-2140-2469
AD  - Department of Chemical Engineering, College of Engineering, King Saud University, 
      Riyadh, Saudi Arabia.
FAU - Shakir, Imran
AU  - Shakir I
AD  - Sustainable Energy Technologies (SET) Center, College of Engineering, King Saud 
      University, Riyadh, Saudi Arabia.
FAU - Aftab, Saira
AU  - Aftab S
AD  - School of Biological Sciences, University of the Punjab, Lahore, Pakistan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200817
PL  - England
TA  - J Tissue Eng Regen Med
JT  - Journal of tissue engineering and regenerative medicine
JID - 101308490
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Galactans)
RN  - 0 (Hydrogels)
RN  - 0 (Mannans)
RN  - 0 (Plant Gums)
RN  - 0 (Polymers)
RN  - 0 (Xylans)
RN  - 9040-27-1 (arabinoxylan)
RN  - E89I1637KE (guar gum)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/*pharmacology
MH  - *Bandages
MH  - Biocompatible Materials/*pharmacology
MH  - Cell Line
MH  - Cell Shape/drug effects
MH  - Drug Liberation
MH  - Galactans/chemistry/*pharmacology
MH  - Hydrogels/chemistry/*pharmacology
MH  - Mannans/chemistry/*pharmacology
MH  - Materials Testing
MH  - Mice
MH  - Microbial Sensitivity Tests
MH  - Plant Gums/chemistry/*pharmacology
MH  - Polymers/chemistry
MH  - Pseudomonas aeruginosa/drug effects
MH  - Skin/drug effects/*pathology
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Staphylococcus aureus/drug effects
MH  - Tensile Strength
MH  - Wounds and Injuries/*pathology
MH  - Xylans/chemistry/*pharmacology
OTO - NOTNLM
OT  - arabinoxylan
OT  - biocompatible
OT  - biodegradable hydrogels
OT  - skin wound healing
OT  - stimuli-responsive
EDAT- 2020/08/08 06:00
MHDA- 2021/09/30 06:00
CRDT- 2020/08/08 06:00
PHST- 2020/04/13 00:00 [received]
PHST- 2020/07/14 00:00 [revised]
PHST- 2020/07/15 00:00 [accepted]
PHST- 2020/08/08 06:00 [pubmed]
PHST- 2021/09/30 06:00 [medline]
PHST- 2020/08/08 06:00 [entrez]
AID - 10.1002/term.3115 [doi]
PST - ppublish
SO  - J Tissue Eng Regen Med. 2020 Oct;14(10):1488-1501. doi: 10.1002/term.3115. Epub 
      2020 Aug 17.