PMID- 32763157
OWN - NLM
STAT- MEDLINE
DCOM- 20210701
LR  - 20210701
IS  - 2213-6711 (Electronic)
IS  - 2213-6711 (Linking)
VI  - 15
IP  - 3
DP  - 2020 Sep 8
TI  - MiR-126 Regulates Properties of SOX9(+) Liver Progenitor Cells during Liver 
      Repair by Targeting Hoxb6.
PG  - 706-720
LID - S2213-6711(20)30282-4 [pii]
LID - 10.1016/j.stemcr.2020.07.005 [doi]
AB  - Liver progenitor cells (LPCs) have a remarkable contribution to the hepatocytes 
      and ductal cells when normal hepatocyte proliferation is severely impaired. As a 
      biomarker for LPCs, Sry-box 9 (Sox9) plays critical roles in liver homeostasis 
      and repair in response to injury. However, the regulation mechanism of Sox9 in 
      liver physiological and pathological state remains unknown. In this study, we 
      found that miR-126 positively regulated the expression of Sox9, the proliferation 
      and differentiation of SOX9(+) LPCs by suppressing the translation of homeobox b6 
      (Hoxb6). As a transcription factor, HOXB6 directly binds to the promoter of Sox9 
      to inhibit Sox9 expression, resulting in the destruction of the properties of 
      SOX9(+) LPCs in CCl(4)-induced liver injury. These findings revealed the role of 
      miR-126 in regulating SOX9(+) LPCs fate by targeting Hoxb6 in liver injury 
      repair. Our findings suggest the potential role of miR-126 as a nucleic acid 
      therapy drug target for liver failure.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Yan, Yi
AU  - Yan Y
AD  - College of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural 
      University, Wuhan, Hubei 430070, China.
FAU - Wang, Rui
AU  - Wang R
AD  - College of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural 
      University, Wuhan, Hubei 430070, China.
FAU - Hu, Xiongji
AU  - Hu X
AD  - College of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural 
      University, Wuhan, Hubei 430070, China.
FAU - Wang, Shichao
AU  - Wang S
AD  - College of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural 
      University, Wuhan, Hubei 430070, China.
FAU - Zhang, Liang
AU  - Zhang L
AD  - College of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural 
      University, Wuhan, Hubei 430070, China.
FAU - Hou, Chenjiao
AU  - Hou C
AD  - College of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural 
      University, Wuhan, Hubei 430070, China.
FAU - Zhang, Lisheng
AU  - Zhang L
AD  - College of Veterinary Medicine, Bio-medical Center, Huazhong Agricultural 
      University, Wuhan, Hubei 430070, China. Electronic address: 
      lishengzhang@mail.hzau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200806
PL  - United States
TA  - Stem Cell Reports
JT  - Stem cell reports
JID - 101611300
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Hoxb6 protein, mouse)
RN  - 0 (MIRN126 microRNA, mouse)
RN  - 0 (MicroRNAs)
RN  - 0 (SOX9 Transcription Factor)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Carbon Tetrachloride
MH  - Cell Differentiation/genetics
MH  - Cell Line, Tumor
MH  - Cell Proliferation/genetics
MH  - Chronic Disease
MH  - Dependovirus/metabolism
MH  - Disease Models, Animal
MH  - Hepatocytes/cytology
MH  - Homeodomain Proteins/*metabolism
MH  - Liver/injuries/*metabolism/physiopathology
MH  - *Liver Regeneration
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - MicroRNAs/*metabolism
MH  - NIH 3T3 Cells
MH  - SOX9 Transcription Factor/*metabolism
MH  - Stem Cells/*metabolism
PMC - PMC7486193
OTO - NOTNLM
OT  - MiR-126
OT  - differentiation
OT  - injury repair
OT  - liver stem cells
OT  - proliferation
EDAT- 2020/08/09 06:00
MHDA- 2021/07/02 06:00
PMCR- 2020/08/06
CRDT- 2020/08/09 06:00
PHST- 2020/01/14 00:00 [received]
PHST- 2020/07/07 00:00 [revised]
PHST- 2020/07/08 00:00 [accepted]
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2021/07/02 06:00 [medline]
PHST- 2020/08/09 06:00 [entrez]
PHST- 2020/08/06 00:00 [pmc-release]
AID - S2213-6711(20)30282-4 [pii]
AID - 10.1016/j.stemcr.2020.07.005 [doi]
PST - ppublish
SO  - Stem Cell Reports. 2020 Sep 8;15(3):706-720. doi: 10.1016/j.stemcr.2020.07.005. 
      Epub 2020 Aug 6.