PMID- 32763433
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 327
DP  - 2020 Nov 10
TI  - Anticancer DOX delivery system based on CNTs: Functionalization, targeting and 
      novel technologies.
PG  - 198-224
LID - S0168-3659(20)30432-6 [pii]
LID - 10.1016/j.jconrel.2020.08.001 [doi]
AB  - Carbon nanotubes (CNTs) have attracted significant attention as promising 
      nanocarriers in the field of drug delivery, due to their properties such as 
      ultrahigh length-to-diameter ratio and excellent cellular uptake. The unique 
      conjugated structure of CNTs suits their surface for pi-pi stacking interactions 
      with many drugs and therapeutic molecules with aromatic rings, including 
      anthracyclines. Doxorubicin(DOX), as an anthracycline anticancer drug, can be 
      easily adsorbed onto the surface of CNTs via pi-pi stacking, making the CNTs-DOX 
      conjugation, as the basis of CNT-based drug delivery systems(DDSs) for the 
      delivery of DOX to cancer cells. In this review article, the delivery of DOX 
      using various CNT-based DDSs is presented. In addition, the current progress of 
      in vitro and in vivo research on the design of DOX loaded CNT-based DDSs, 
      including the functionalization and targeting of CNTs, has been reviewed, 
      focusing particularly on emerging technologies and techniques to date for DOX 
      delivery by CNT-based DDSs.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Yaghoubi, Alireza
AU  - Yaghoubi A
AD  - Department of Chemistry, University of Zanjan, Zanjan 4537138791, Iran.
FAU - Ramazani, Ali
AU  - Ramazani A
AD  - Department of Chemistry, University of Zanjan, Zanjan 4537138791, Iran; Research 
      Institute of Modern Biological Techniques (RIMBT), University of Zanjan, Zanjan 
      4537138791, Iran. Electronic address: aliramazani@znu.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200805
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Nanotubes, Carbon)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Antibiotics, Antineoplastic
MH  - *Antineoplastic Agents
MH  - Doxorubicin
MH  - Drug Delivery Systems
MH  - *Nanotubes, Carbon
OTO - NOTNLM
OT  - Anticancer doxorubicin
OT  - Carbon nanotube -based drug delivery systems (CNT-based DDSs)
OT  - Carbon nanotubes
OT  - Drug delivery
EDAT- 2020/08/09 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/08/09 06:00
PHST- 2020/03/27 00:00 [received]
PHST- 2020/07/31 00:00 [revised]
PHST- 2020/08/01 00:00 [accepted]
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/08/09 06:00 [entrez]
AID - S0168-3659(20)30432-6 [pii]
AID - 10.1016/j.jconrel.2020.08.001 [doi]
PST - ppublish
SO  - J Control Release. 2020 Nov 10;327:198-224. doi: 10.1016/j.jconrel.2020.08.001. 
      Epub 2020 Aug 5.