PMID- 32763439
OWN - NLM
STAT- MEDLINE
DCOM- 20210521
LR  - 20210521
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 144
DP  - 2020 Oct
TI  - Acrylamide exposure represses neuronal differentiation, induces cell apoptosis 
      and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids.
PG  - 111643
LID - S0278-6915(20)30533-0 [pii]
LID - 10.1016/j.fct.2020.111643 [doi]
AB  - Acrylamide (ACR) is a common food contaminant with neurotoxic effects that are 
      formed in the Maillard browning reaction during the heat processing of food. 
      Importantly, pregnant women are also exposed to ACR in food during pregnancy and 
      thus, the fetus is likely affected. However, the mechanisms of ACR-caused 
      neurotoxicity on human brain development are still unclear. Many recent studies 
      employed cerebral organoids based on human embryonic stem cells (hESC) for 
      investigating human neurodevelopmental disorders and toxicity. Here, we generated 
      hESC-derived cerebral organoids to evaluate the neurodevelopmental toxicity of 
      ACR. The results indicated that exposure to ACR significantly altered the 
      transcriptional profile, increased nuclear factor erythroid 2-related factor 2 
      (NRF2)-mediated gene expression, induced cell apoptosis, repressed neuronal 
      differentiation, and promoted tau hyperphosphorylation in cerebral organoids, 
      which may contribute to ACR-induced neurodevelopmental toxicity. These results 
      indicate that the risk of transplacental exposure of the fetus to ACR should be 
      evaluated and pregnant mothers should limit their exposure to ACR.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Bu, Qian
AU  - Bu Q
AD  - West China School of Public Health and Heathy Food Evaluation Research Center and 
      West China Fourth Hospital, Sichuan University, Chengdu 610041, China; National 
      Chengdu Center for Safety Evaluation of Drugs, State Key Lab of 
      Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, 
      West China Medical School, Sichuan University, Chengdu, 610041, China; Department 
      of Food Science and Technology, College of Biomass and Engineering and Healthy 
      Food Evaluation Research Center, Sichuan University, Chengdu, 610065, China.
FAU - Huang, Yan
AU  - Huang Y
AD  - West China School of Public Health and Heathy Food Evaluation Research Center and 
      West China Fourth Hospital, Sichuan University, Chengdu 610041, China; Department 
      of Food Science and Technology, College of Biomass and Engineering and Healthy 
      Food Evaluation Research Center, Sichuan University, Chengdu, 610065, China.
FAU - Li, Meng
AU  - Li M
AD  - National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of 
      Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, 
      West China Medical School, Sichuan University, Chengdu, 610041, China.
FAU - Dai, Yanping
AU  - Dai Y
AD  - National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of 
      Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, 
      West China Medical School, Sichuan University, Chengdu, 610041, China.
FAU - Fang, Xin
AU  - Fang X
AD  - Department of Food Science and Technology, College of Biomass and Engineering and 
      Healthy Food Evaluation Research Center, Sichuan University, Chengdu, 610065, 
      China.
FAU - Chen, Ke
AU  - Chen K
AD  - National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of 
      Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, 
      West China Medical School, Sichuan University, Chengdu, 610041, China.
FAU - Liu, Qian
AU  - Liu Q
AD  - National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of 
      Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, 
      West China Medical School, Sichuan University, Chengdu, 610041, China.
FAU - Xue, Aiqin
AU  - Xue A
AD  - National Chengdu Center for Safety Evaluation of Drugs, State Key Lab of 
      Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, 
      West China Medical School, Sichuan University, Chengdu, 610041, China.
FAU - Zhong, Kai
AU  - Zhong K
AD  - Department of Food Science and Technology, College of Biomass and Engineering and 
      Healthy Food Evaluation Research Center, Sichuan University, Chengdu, 610065, 
      China.
FAU - Huang, Yina
AU  - Huang Y
AD  - West China School of Public Health and Heathy Food Evaluation Research Center and 
      West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
FAU - Gao, Hong
AU  - Gao H
AD  - Department of Food Science and Technology, College of Biomass and Engineering and 
      Healthy Food Evaluation Research Center, Sichuan University, Chengdu, 610065, 
      China.
FAU - Cen, Xiaobo
AU  - Cen X
AD  - West China School of Public Health and Heathy Food Evaluation Research Center and 
      West China Fourth Hospital, Sichuan University, Chengdu 610041, China; National 
      Chengdu Center for Safety Evaluation of Drugs, State Key Lab of 
      Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, 
      West China Medical School, Sichuan University, Chengdu, 610041, China. Electronic 
      address: xbcen@scu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200805
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (MAPT protein, human)
RN  - 0 (tau Proteins)
RN  - 20R035KLCI (Acrylamide)
SB  - IM
MH  - Acrylamide/*toxicity
MH  - Apoptosis/*drug effects
MH  - Cell Differentiation/*drug effects
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Human Embryonic Stem Cells/*metabolism
MH  - Humans
MH  - Neurons/cytology/*drug effects
MH  - Organoids/*metabolism
MH  - Phosphorylation
MH  - tau Proteins/*metabolism
OTO - NOTNLM
OT  - Acrylamide
OT  - Apoptosis
OT  - Cerebral organoid
OT  - Neuronal differentiation
OT  - p-tau
EDAT- 2020/08/09 06:00
MHDA- 2021/05/22 06:00
CRDT- 2020/08/09 06:00
PHST- 2020/04/06 00:00 [received]
PHST- 2020/07/18 00:00 [revised]
PHST- 2020/07/21 00:00 [accepted]
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2021/05/22 06:00 [medline]
PHST- 2020/08/09 06:00 [entrez]
AID - S0278-6915(20)30533-0 [pii]
AID - 10.1016/j.fct.2020.111643 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2020 Oct;144:111643. doi: 10.1016/j.fct.2020.111643. Epub 2020 
      Aug 5.