PMID- 32764395
OWN - NLM
STAT- MEDLINE
DCOM- 20210217
LR  - 20210217
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 16
DP  - 2020 Aug 5
TI  - Dietary Protein and Fat Intake Affects Diabetes Risk with CDKAL1 Genetic Variants 
      in Korean Adults.
LID - 10.3390/ijms21165607 [doi]
LID - 5607
AB  - Cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) 
      is one of the strongest diabetes loci identified to date; evidence suggests that 
      it plays an important role in insulin secretion. Dietary factors that affect 
      insulin demand might enhance the risk of diabetes associated with CDKAL1 
      variants. Our aim was to examine the interactions between dietary protein and fat 
      intake and CDKAL1 genetic variants in relation to the risk of diabetes in Korean 
      adults. Single nucleotide polymorphisms (SNPs) were selected with a genome-wide 
      association study (GWAS) for diabetes after adjustment for age, gender, and 
      examination site. Using data from the Health Examinees (HEXA) Study of the Korean 
      Genome and Epidemiology Study (KoGES), 3988 middle-aged Korean adults between 
      40-76 years of age (2034 men and 1954 women) were included in the study. Finally, 
      rs7756992 located within the CDKAL1 gene region was selected from GWAS (p-value < 
      5 x 10(-8)). Multivariable logistic regression models were used to evaluate the 
      interactions between genotypes and dietary protein and fat intake in relation to 
      diabetes risk after adjustment for age, gender, BMI, waist circumference, 
      physical activity, smoking status, drinking habits, and examination site. 
      Significant interactions between CDKAL1 rs7756992 and dietary protein and fat 
      intake for the risk of diabetes were observed in men (p-value < 0.05). In women, 
      significant interactions between dietary protein and fat intake and CDKAL1 
      variants (rs7756992) were associated with increased risk of diabetes (p-value < 
      0.05). Dietary protein and fat intake interacted differently with CDKAL1 variants 
      in relation to the risk of diabetes in Korean adults of both genders. These 
      findings indicate that CDKAL1 variants play a significant role in diabetes and 
      that dietary protein and fat intake could affect these associations.
FAU - Choi, Woo Jeong
AU  - Choi WJ
AD  - Department of Food and Nutrition, Inha University, 100 Inha-ro, Michuhol-gu, 
      Incheon 22212, Korea.
FAU - Jin, Hyun-Seok
AU  - Jin HS
AUID- ORCID: 0000-0002-3673-9806
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, Asan, Chungnam 31499, Korea.
FAU - Kim, Sung-Soo
AU  - Kim SS
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, Asan, Chungnam 31499, Korea.
FAU - Shin, Dayeon
AU  - Shin D
AUID- ORCID: 0000-0003-0828-184X
AD  - Department of Food and Nutrition, Inha University, 100 Inha-ro, Michuhol-gu, 
      Incheon 22212, Korea.
LA  - eng
GR  - 2020R1G1A1004940/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20200805
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - EC 2.1.1.- (tRNA Methyltransferases)
RN  - EC 2.8.4.5 (CDKAL1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus/epidemiology/*genetics/metabolism/pathology
MH  - Dietary Fats/*metabolism
MH  - Dietary Proteins/*metabolism
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - tRNA Methyltransferases/*genetics
PMC - PMC7460637
OTO - NOTNLM
OT  - CDKAL1 variants
OT  - Korean Genome and Epidemiology Study (KoGES)
OT  - diabetes
OT  - single nucleotide polymorphisms
COIS- The authors declare no conflict of interest.
EDAT- 2020/08/09 06:00
MHDA- 2021/02/18 06:00
PMCR- 2020/08/01
CRDT- 2020/08/09 06:00
PHST- 2020/06/15 00:00 [received]
PHST- 2020/07/23 00:00 [revised]
PHST- 2020/07/29 00:00 [accepted]
PHST- 2020/08/09 06:00 [entrez]
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2021/02/18 06:00 [medline]
PHST- 2020/08/01 00:00 [pmc-release]
AID - ijms21165607 [pii]
AID - ijms-21-05607 [pii]
AID - 10.3390/ijms21165607 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Aug 5;21(16):5607. doi: 10.3390/ijms21165607.