PMID- 32764901
OWN - NLM
STAT- MEDLINE
DCOM- 20201229
LR  - 20220416
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Print)
IS  - 1176-9092 (Linking)
VI  - 15
DP  - 2020
TI  - Frailty and Post-Operative Outcomes in the Older Patients Undergoing Elective 
      Posterior Thoracolumbar Fusion Surgery.
PG  - 1141-1150
LID - 10.2147/CIA.S245419 [doi]
AB  - BACKGROUND AND AIM: Frailty is an independent predictor of mortality and adverse 
      events (AEs) in patients undergoing surgery. This study aimed to quantify the 
      ability of Modified Frailty Index (mFI) to predict AEs in older patients 
      undergoing elective posterior thoracolumbar fusion surgery. METHODS: We 
      retrospectively reviewed the results of 426 patients with the following diagnoses 
      and follow-up evaluations of at least 12 months duration: lumbar disc herniation, 
      125; degenerative spondylolisthesis, 81; lumbar spinal canal stenosis, 187; and 
      adult spinal deformities, 33. The cases were divided into two groups. The long 
      spinal fusion (LSF) group was defined as >/=3 spinal levels with segmental 
      pedicle-screw fixation. Short spinal fusion (SSF) were defined with at most two 
      levels. The mFI used in the present study is an 11-variable assessment. The 
      association of frailty with AEs was determined after adjusting for known and 
      suspected confounders. RESULTS: Frailty was presented in 66 patients (15.5%) 
      within the total population (LSF, 21.9% and SSF, 11.8%). Rates of AEs assessed in 
      the study increased stepwise with an increase in the mFI for the two groups. The 
      severity of frailty was an independent predictor of any, major, and minor 
      complications in the LSF group and any, minor complication in the SSF group 
      (P<0.05). A comparison of post-operative clinical outcomes showed that the ODI 
      and SF-36 scores deteriorated as the mFI increased. CONCLUSION: Frailty was shown 
      to be an independent predictor of AEs in older patients undergoing elective 
      posterior thoracolumbar fusion surgery, especially for patients undergoing LSF.
CI  - (c) 2020 Sun et al.
FAU - Sun, Wenzhi
AU  - Sun W
AUID- ORCID: 0000-0001-9721-0300
AD  - Department of Orthopaedics, Capital Medical University Xuanwu Hospital, Beijing 
      100053, People's Republic of China.
FAU - Lu, Shibao
AU  - Lu S
AD  - Department of Orthopaedics, Capital Medical University Xuanwu Hospital, Beijing 
      100053, People's Republic of China.
FAU - Kong, Chao
AU  - Kong C
AD  - Department of Orthopaedics, Capital Medical University Xuanwu Hospital, Beijing 
      100053, People's Republic of China.
FAU - Li, Zhongen
AU  - Li Z
AD  - Department of Orthopaedics, Capital Medical University Xuanwu Hospital, Beijing 
      100053, People's Republic of China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Orthopaedics, Capital Medical University Xuanwu Hospital, Beijing 
      100053, People's Republic of China.
FAU - Zhang, Sitao
AU  - Zhang S
AD  - Department of Orthopaedics, Capital Medical University Xuanwu Hospital, Beijing 
      100053, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20200714
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
RN  - Intervertebral disc disease
SB  - IM
MH  - Aged
MH  - Elective Surgical Procedures/adverse effects
MH  - Female
MH  - Frail Elderly/*statistics & numerical data
MH  - Frailty/*epidemiology
MH  - Humans
MH  - Intervertebral Disc Degeneration/*physiopathology/surgery
MH  - Intervertebral Disc Displacement/*physiopathology/surgery
MH  - Lumbar Vertebrae/surgery
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*epidemiology
MH  - Postoperative Period
MH  - Retrospective Studies
MH  - Spinal Fusion/adverse effects
MH  - Spinal Stenosis/*physiopathology/surgery
MH  - Treatment Outcome
PMC - PMC7369366
OTO - NOTNLM
OT  - clinical evaluation
OT  - complications
OT  - degenerative spine disease
OT  - elderly
OT  - frailty
OT  - risk stratification
OT  - spinal surgery
COIS- The authors report no conflicts of interest.
EDAT- 2020/08/09 06:00
MHDA- 2020/12/30 06:00
PMCR- 2020/07/14
CRDT- 2020/08/09 06:00
PHST- 2020/01/09 00:00 [received]
PHST- 2020/07/03 00:00 [accepted]
PHST- 2020/08/09 06:00 [entrez]
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2020/12/30 06:00 [medline]
PHST- 2020/07/14 00:00 [pmc-release]
AID - 245419 [pii]
AID - 10.2147/CIA.S245419 [doi]
PST - epublish
SO  - Clin Interv Aging. 2020 Jul 14;15:1141-1150. doi: 10.2147/CIA.S245419. 
      eCollection 2020.