PMID- 32764929
OWN - NLM
STAT- MEDLINE
DCOM- 20200918
LR  - 20240329
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 15
DP  - 2020
TI  - Intelligent Drug Delivery Microparticles with Visual Stimuli-Responsive 
      Structural Color Changes.
PG  - 4959-4967
LID - 10.2147/IJN.S249009 [doi]
AB  - BACKGROUND: Particle-based drug delivery systems (DDSs) have a demonstrated value 
      for drug discovery and development. However, some problems remain to be solved, 
      such as limited stimuli, visual-monitoring. AIM: To develop an intelligent 
      multicolor DDSs with both near-infrared (NIR) controlled release and macroscopic 
      color changes. MATERIALS AND METHODS: Microparticles comprising GO/pNIPAM/PEGDA 
      composite hydrogel inverse opal scaffolds, with dextran and calcium alginate 
      hydrogel were synthesized using SCCBs as the template. The morphology of 
      microparticle was observed under scanning electron microscopy, and 
      FITC-dextran-derived green fluorescence images were determined using a confocal 
      laser scanning microscope. During the drug release, FITC-dextran-derived green 
      fluorescence images were captured using fluorescent inverted microscope. The 
      relationship between the power of NIR and the drug release rate was obtained 
      using the change in optical density (OD) values. Finally, the amount of drug 
      released could be estimated quantitatively used the structural color or the 
      reflection peak position. RESULTS: A fixed concentration 8% (v/v) of PEGDA and 
      4mg/mL of GO was chosen as the optimal concentration based on the balance between 
      appropriate volume shrinkage and structure color. The FITC-dextran was uniformly 
      encapsulated in the particles by using 0.2 wt% sodium alginate. The microcarriers 
      shrank because of the photothermal response and the intrinsic fluorescence 
      intensity of FITC-dextran in the microparticles gradually decreased at the same 
      time, indicating drug release. With an increasing duration of NIR irradiation, 
      the microparticles gradually shrank, the reflection peak shifted toward blue and 
      the structural color changed from red to orange, yellow, green, cyan, and blue 
      successively. The drug release quantity can be predicted by the structural color 
      of microparticles. CONCLUSION: The multicolor microparticles have great potential 
      in drug delivery systems because of its vivid reporting color, excellent 
      photothermal effect, and the good stimuli responsivity.
CI  - (c) 2020 Sun et al.
FAU - Sun, Xiaoyan
AU  - Sun X
AD  - Key Laboratory of Biomedical Functional Materials, School of Science, China 
      Pharmaceutical University, Nanjing, Jiangsu 210009, People's Republic of China.
FAU - Liu, Lingzi
AU  - Liu L
AUID- ORCID: 0000-0001-5300-6308
AD  - Key Laboratory of Biomedical Functional Materials, School of Science, China 
      Pharmaceutical University, Nanjing, Jiangsu 210009, People's Republic of China.
FAU - Zou, Hui
AU  - Zou H
AD  - Key Laboratory of Biomedical Functional Materials, School of Science, China 
      Pharmaceutical University, Nanjing, Jiangsu 210009, People's Republic of China.
FAU - Yao, Caixia
AU  - Yao C
AD  - Key Laboratory of Biomedical Functional Materials, School of Science, China 
      Pharmaceutical University, Nanjing, Jiangsu 210009, People's Republic of China.
FAU - Yan, Zhengyu
AU  - Yan Z
AD  - Key Laboratory of Biomedical Functional Materials, School of Science, China 
      Pharmaceutical University, Nanjing, Jiangsu 210009, People's Republic of China.
FAU - Ye, Baofen
AU  - Ye B
AD  - Key Laboratory of Biomedical Functional Materials, School of Science, China 
      Pharmaceutical University, Nanjing, Jiangsu 210009, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20200712
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 0 (Acrylic Resins)
RN  - 0 (Alginates)
RN  - 0 (Dextrans)
RN  - 0 (Drug Carriers)
RN  - 0 (Hydrogels)
RN  - 0 (fluorescein isothiocyanate dextran)
RN  - 0 (poly(ethylene glycol)diacrylate)
RN  - 25189-55-3 (poly-N-isopropylacrylamide)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - I223NX31W9 (Fluorescein-5-isothiocyanate)
SB  - IM
MH  - Acrylic Resins/chemistry
MH  - Alginates/chemistry
MH  - Color
MH  - Dextrans/chemistry
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Fluorescein-5-isothiocyanate/analogs & derivatives/chemistry
MH  - Hydrogels/chemistry
MH  - *Microspheres
MH  - Optical Phenomena
MH  - Polyethylene Glycols/chemistry
PMC - PMC7367737
OTO - NOTNLM
OT  - color change
OT  - drug delivery
OT  - graphene oxide
OT  - microparticles
OT  - photothermal effect
COIS- Xiaoyan Sun, Hui Zou, Caixia Yao and Baofen Ye report an issued patent: 
      CN201910226335.8 (Applicant (patent right): China Pharmaceutical University; 
      Preparation method and application of controlled release microsphere carrier 
      capable of visual monitoring; Application date: 2019.06.21). The authors report 
      no other possible conflicts of interest in this work.
EDAT- 2020/08/09 06:00
MHDA- 2020/09/20 06:00
PMCR- 2020/07/12
CRDT- 2020/08/09 06:00
PHST- 2020/02/09 00:00 [received]
PHST- 2020/06/18 00:00 [accepted]
PHST- 2020/08/09 06:00 [entrez]
PHST- 2020/08/09 06:00 [pubmed]
PHST- 2020/09/20 06:00 [medline]
PHST- 2020/07/12 00:00 [pmc-release]
AID - 249009 [pii]
AID - 10.2147/IJN.S249009 [doi]
PST - epublish
SO  - Int J Nanomedicine. 2020 Jul 12;15:4959-4967. doi: 10.2147/IJN.S249009. 
      eCollection 2020.